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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Pimozide Ca+ Dopamine Dopamine Pimozide Pimozide L-Dopa CO2 Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade L-Tyrosine Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Pimozide is a D2 and D3 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ motor and phonic tics in Tourette's Disorder Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Pimozide is taken orally
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Pimozide Calcium Dopamine Dopamine Pimozide Pimozide L-Dopa Carbon dioxide Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade L-Tyrosine
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Orap Ca+ LDP LDP Orap Orap L-Dopa CO2 BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Tyr Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Pimozide is a D2 and D3 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ motor and phonic tics in Tourette's Disorder Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Pimozide is taken orally