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Pathway Description
Methylglyoxal Degradation I
Escherichia coli HS
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2024-11-11
Last Updated: 2024-11-11
The degradation of methylglyoxal starts with methylglyoxal being degraded by interacting with glutathione and a glyoxalase resulting in the release of a (R)-S-lactoylglutatione. This compound in turn reacts with a water molecule through a glyoxalase II resulting in the releas of glutathione, a hydrogen ion and an R-lactate. The R-lactate in turn reacts with an ubiquinone through a D-lactate dehydrogenase resulting in the release of an ubiquinol and a pyruvate which can then be incorporated the pyruvate metabolism
References
Methylglyoxal Degradation I References
Clugston SL, Daub E, Kinach R, Miedema D, Barnard JF, Honek JF: Isolation and sequencing of a gene coding for glyoxalase I activity from Salmonella typhimurium and comparison with other glyoxalase I sequences. Gene. 1997 Feb 20;186(1):103-11. doi: 10.1016/s0378-1119(96)00691-9.
Pubmed: 9047352
Clugston SL, Barnard JF, Kinach R, Miedema D, Ruman R, Daub E, Honek JF: Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions. Biochemistry. 1998 Jun 16;37(24):8754-63. doi: 10.1021/bi972791w.
Pubmed: 9628737
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
O'Young J, Sukdeo N, Honek JF: Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme. Arch Biochem Biophys. 2007 Mar 1;459(1):20-6. doi: 10.1016/j.abb.2006.11.024. Epub 2006 Dec 6.
Pubmed: 17196158
Campbell HD, Rogers BL, Young IG: Nucleotide sequence of the respiratory D-lactate dehydrogenase gene of Escherichia coli. Eur J Biochem. 1984 Oct 15;144(2):367-73. doi: 10.1111/j.1432-1033.1984.tb08473.x.
Pubmed: 6386470
Rule GS, Pratt EA, Chin CC, Wold F, Ho C: Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli. J Bacteriol. 1985 Mar;161(3):1059-68.
Pubmed: 3882663
Kohn LD, Kaback HR: Mechanisms of active transport in isolated bacterial membrane vesicles. XV. Purification and properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli. J Biol Chem. 1973 Oct 25;248(20):7012-7.
Pubmed: 4582730
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002125
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