PathBank

Pathway Description

tRNA Charging

Acinetobacter junii SH205

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2024-12-18

Last Updated: 2025-07-10

This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged.

References

tRNA Charging References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000820

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate
		Glycine
		Hydrogen Ion
		L-Alanine
		L-Arginine
		L-Asparagine
		L-Aspartic acid
		L-Cysteine
		L-Glutamic acid
		L-Glutamine
		L-Histidine
		L-Isoleucine
		L-Leucine
		L-Lysine
		L-Methionine
		L-Phenylalanine
		L-Proline
		L-Serine
		L-Threonine
		L-Tryptophan
		L-Tyrosine
		L-Valine
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		ABC transporter, ATP-binding protein
		ABC transporter, ATP-binding protein
		ABC transporter, permease protein
		ABC transporter, permease protein
		ABC transporter, substrate-binding protein, aliphatic sulfonates family
		ABC transporter, substrate-binding protein, aliphatic sulfonates family
		Arginine--tRNA ligase
		Aspartate--tRNA(Asp/Asn) ligase
		Cysteine--tRNA ligase
		D-methionine transport system permease protein MetI
		D-serine/D-alanine/glycine transporter
		DUF423 domain-containing protein
		DUF4349 domain-containing protein
		DUF490 domain-containing protein
		Glutamate--tRNA ligase
		Glycine--tRNA ligase alpha subunit
		Histidine--tRNA ligase
		Inner membrane protein
		Isoleucine--tRNA ligase
		Lysine--tRNA ligase-like protein GenX
		MerR, DNA binding protein
		NADH-quinone oxidoreductase subunit J
		NLPA lipoprotein
		Oxidoreductase, short chain dehydrogenase/reductase family protein
		Phenylalanine--tRNA ligase alpha subunit
		Proline-specific permease ProY
		Sulfatase-modifying factor enzyme domain-containing protein
		Sulfate/thiosulfate import ATP-binding protein CysA
		Threonine--tRNA ligase
		Transcriptional regulator, AraC family
		Tryptophan--tRNA ligase
		Tyrosine--tRNA ligase
		Unknown
		Urea ABC transporter, ATP-binding protein UrtE
		Urea ABC transporter, permease protein UrtB
		Urea ABC transporter, permease protein UrtC
		Urea ABC transporter, urea binding protein
		Valine--tRNA ligase