Sulfisoxazole is a short-acting antibiotic from the sulfonamide drug class. It has activity against a wide range of gram-negative and gram-positive organisms. This drug is indicated in the treatment of many infections: urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, nocardiosis, chancroid, toxoplasmosis, malaria, and many others. This drug is bacteriostatic; it inhibits the replication of bacteria by inhibiting the dihydropteroate synthase. This enzyme is responsible for one of the reactions to synthesize folic acid in bacteria by the condensation of the pteridine with para-aminobenzoic acid (PABA). This drug stops the replication of the bacteria (bacteriostatic). Sulfisoxazole is administered as an oral tablet.

Sulfisoxazole Pathway References