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Pathway Description
Gluconate utilization: gntK, gntU
Bacillus subtilis
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2025-07-09
Last Updated: 2025-07-09
The regulation of the gntKU operon. The operon is inhibited by gntR (HTH-type transcriptional regulator) and activated by gluconate. GntR binds to the promoter, inhibiting crp from binding and transcribing the operon. When gluconate is present in the cell, gntR releases the promoter, allowing for expression of the operon. There are two products of this operon: gntK (Thermoresistant gluconokinase) and gntU (Low-affinity gluconate transporter). Both products are used in the utilization of gluconate. GntK is an enzyme used to turn gluconate to gluconate-6-phophate. GntU is a transporter used to transport gluconate into the cell.
References
Gluconate utilization: gntK, gntU References
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0565260
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