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CHEBI:16015 ChEBI C00437 KEGG Compound 6022 PubChem-compound 7722-84-1 CAS 2.0 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 1.0 937 ChemSpider Succinic acid semialdehyde C00555 KEGG Compound Succinate-semialdehyde dehydrogenase [NADP+] 4-AMINO-BUTYRALDEHYDE BioCyc HMDB0003125 HMDB 1.0 439153 PubChem-compound 1.0 50 ChemSpider 1.0 388369 ChemSpider 4-Aminobutyraldehyde ornithine decarboxylase ATP BioCyc H4N Ammonium 18.034374 CHEBI:16265 ChEBI Reaction2694 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT 4.1.1.17 false 4.1.1.17 Hydrogen Ion + Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 1.0 1.2.1.79 false 1.2.1.79 NADP + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADPH + Succinic acid LEFT_TO_RIGHT 1.2.1.16 false 1.2.1.16 NAD + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADH + Succinic acid LEFT_TO_RIGHT SMILES NCCCCNC(=O)CC[C@H](N)C(O)=O 1.2.1.19 false 1.2.1.19 4-Aminobutyraldehyde + NAD + Water → Hydrogen Ion + NADH + gamma-Aminobutyric acid LEFT_TO_RIGHT 2.6.1.19 false 2.6.1.19 Oxoglutaric acid + gamma-Aminobutyric acid → L-Glutamic acid + Succinic acid semialdehyde LEFT_TO_RIGHT P23908 UniProt 1.0 HMDB0001080 HMDB 5742 ChemSpider NADH C00334 KEGG Compound CHEBI:16474 ChEBI 952 ChemSpider Acetylglutamate kinase Gamma-glutamylputrescine oxidoreductase P18335 UniProt Acetyl-CoA CHEBI:16240 ChEBI Aldehyde dehydrogenase-like protein yneI 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS SMILES NCCCCN 23724570 PubChem-compound 1.0 5105-96-4 CAS 2.0 CHEBI:17148 ChEBI Ammonium Hydrogen Ion Putrescine aminotransferase C00232 KEGG Compound Cytosol 1.0 Adenosine triphosphate SUC BioCyc Acetylornithine/succinyldiaminopimelate aminotransferase CHEBI:49260 ChEBI Gamma-glutamyl-gamma-aminobutyrate hydrolase C00009 KEGG Compound C00008 KEGG Compound 110-60-1 CAS C00007 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI Hydrogen Ion C00001 KEGG Compound N-Acetylornithine C00005 KEGG Compound CPD-9000 BioCyc 2.0 CHEBI:18367 ChEBI C00004 KEGG Compound N-Acetylglutamic acid 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 6205-08-9 CAS Glycolysis and Pyruvate Dehydrogenase SubPathway C21H28N7O14P2 NAD 664.11694 1.0 TCA Cycle SubPathway C01342 KEGG Compound C00011 KEGG Compound C00010 KEGG Compound HMDB0000902 HMDB 1.0 C4H9NO 4-Aminobutyraldehyde 87.06841 C00134 KEGG Compound 4.0 Q86WD1 UniProt NAD(P) BioCyc HMDB0006456 HMDB 562 TAXONOMY 1.0 H Hydrogen Ion 1.007825 Ornithine Metabolism C4H6O3 Succinic acid semialdehyde 102.03169 56-65-5 CAS 53-84-9 CAS C00027 KEGG Compound L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound ACET BioCyc ReactionCatalysis153673 ACTIVATION 1.0 1.0 PUTRESCINE BioCyc SMP0000802 SMPDB 1.0 C00033 KEGG Compound SMP0000807 SMPDB HMDB0012230 HMDB 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000254 HMDB Water Hydrogen peroxide SMILES OC(=O)CCC(O)=O HYDROGEN-PEROXIDE BioCyc P50457 UniProt P24169 UniProt 4-aminobutyrate aminotransferase_ C15767 KEGG Compound HMDB0001341 HMDB SMP0000813 SMPDB N-Acetyl-L-glutamyl 5-phosphate C00042 KEGG Compound Acetylornithine deacetylase N-Acetylornithine SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 763 ChemSpider CREB3L2-PPARgamma HMDB0000148 HMDB Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1.0 succinate-semialdehyde dehydrogenase (NADP+) 784 PubChem-compound 1.0 C7H11NO5 N-Acetylglutamic acid 189.06372 4390-05-0 CAS Ornithine decarboxylase, inducible SMILES CC(O)=O 7732-18-5 CAS C7H14N2O3 N-Acetylornithine 174.10045 N-acetyl-gamma-glutamyl-phosphate reductase HMDB0001487 HMDB 56-86-0 CAS 1.0 NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 1.0 N-acetylglutamate semialdehyde 1.0 acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase HMDB0001377 HMDB HMDB0001138 HMDB HMDB0001259 HMDB Succinate-semialdehyde dehydrogenase [NADP+] HMDB0000042 HMDB 962 PubChem-compound 5800 ChemSpider C00077 KEGG Compound CO2 Carbon dioxide 43.98983 SMILES N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O Phosphate C00080 KEGG Compound SMILES O=O Oxoglutaric acid 15383-57-0 CAS SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0002111 HMDB 14265-44-2 CAS 58-64-0 CAS HMDB0012161 HMDB Putrescine C15699 KEGG Compound 444493 PubChem-compound C7H12NO8P N-Acetyl-L-glutamyl 5-phosphate 269.03006 22833512 PubChem-compound ACETYL-COA BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 4-AMINO-BUTYRATE BioCyc 4-Aminobutyraldehyde NADH BioCyc Gamma-glutamylputrescine oxidoreductase 1.0 SMILES NCCCC(O)=O NAD BioCyc SMILES CC(=O)N[C@@H](CCC(O)=O)C(O)=O 977 PubChem-compound HMDB0059597 HMDB HMDB0041827 HMDB 1.0 Acetylornithine/succinyldiaminopimelate aminotransferase SMILES NC(CCC(=O)NCCCC=O)C([O-])=O 21865667 ChemSpider 1.0 HMDB0003357 HMDB Reaction163303 false N-acetylglutamate semialdehyde + L-Glutamic acid → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT 30572 ChemSpider 17215925 ChemSpider CHEBI:12575 ChEBI C2H4O2 Acetic acid 60.02113 P78061 UniProt SMILES CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O Succinic acid γ-aminobutyraldehyde dehydrogenase 64-19-7 CAS 13837702 ChemSpider SMILES O SMILES OO Acetyl-CoA SubPathwayOutput Succinic acid semialdehyde 2.0 119 PubChem-compound 118 PubChem-compound HMDB0000538 HMDB C7H11NO5 N-acetylglutamate semialdehyde 189.06372 C9H15N2O4 4-(γ-glutamylamino)butanal 215.10373 ReactionCatalysis2665 ACTIVATION 1.0 C04133 KEGG Compound CHEBI:61508 ChEBI P25526 UniProt 6816 PubChem-compound P22256 UniProt 51 PubChem-compound CHEBI:15846 ChEBI ADP BioCyc 1.0 CHEBI:15729 ChEBI ReactionCatalysis2664 ACTIVATION ReactionCatalysis2663 ACTIVATION 53-59-8 CAS 1.0 acetylornithine deacetylase 1038 PubChem-compound acetylglutamate kinase N-acetylglutamate synthase GO:0005829 GENE ONTOLOGY ReactionCatalysis2679 ACTIVATION ReactionCatalysis2678 ACTIVATION 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 CHEBI:16908 ChEBI 70-26-8 CAS Aldehyde dehydrogenase-like protein yneI O4P Phosphate 94.95342 GLUTAMINE-PUTRESCINE LIGASE γ-glutamyl-γ-aminobutyrate hydrolase NADPH 6026 ChemSpider Acetic acid ReactionCatalysis2688 ACTIVATION ReactionCatalysis2687 ACTIVATION Ornithine HMDB0001414 HMDB NADP C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis2680 ACTIVATION ReactionCatalysis2682 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis2681 ACTIVATION ReactionCatalysis2684 ACTIVATION ReactionCatalysis2683 ACTIVATION C5H12N2O2 Ornithine 132.08987 ReactionCatalysis2686 ACTIVATION ReactionCatalysis2685 ACTIVATION NADPH BioCyc P11446 UniProt 6857435 PubChem-compound Gamma-glutamylputrescine synthetase PW000785 PathWhiz gamma-Aminobutyric acid HMDB0000208 HMDB Carbon dioxide CPD-6641 BioCyc GAMMA-GLUTAMYL-PUTRESCINE BioCyc 218 ChemSpider 58-68-4 CAS C4H9NO2 gamma-Aminobutyric acid 103.06333 L-Glutamic acid HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O HMDB0000214 HMDB HMDB0000217 HMDB SMILES OC(=O)CCC(=O)C(O)=O Oxygen 692-29-5 CAS CHEBI:30915 ChEBI 124-38-9 CAS PW000779 PathWhiz CHEBI:16865 ChEBI ACETYL-GLU BioCyc HMDB0001429 HMDB 4-(Glutamylamino) butanoate 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 1.0 GLT BioCyc CREB3L2-PPARgamma 4.0 53-57-6 CAS CHEBI:15741 ChEBI Oxoglutaric acid 1.0 1.0 4-(γ-glutamylamino)butanal 1112 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI N-acetylglutamate semialdehyde 12.0 1110 PubChem-compound HMDB0000112 HMDB 116 ChemSpider 115 ChemSpider C21H29N7O14P2 NADH 665.12476 HMDB0001206 HMDB 5957 PubChem-compound 1188-37-0 CAS gamma-Aminobutyric acid C4H6O4 Succinic acid 118.02661 Acetylglutamate kinase Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES NCCCC=O SUCC-S-ALD BioCyc CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 2.0 5682 ChemSpider CHEBI:1146900 ChEBI SMILES OC(=O)CCC=O CHEBI:16543 ChEBI CO-A BioCyc Putrescine aminotransferase Gamma-glutamyl-gamma-aminobutyrate hydrolase 5675 ChemSpider 72-89-9 CAS 1078 ChemSpider Ornithine P37906 UniProt Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 14798-03-9 CAS 1080 ChemSpider Putrescine 1.0 P76038 UniProt C4H12N2 Putrescine 88.10005 CHEBI:15422 ChEBI 6557 ChemSpider CHEBI:16878 ChEBI P0A6C8 UniProt C9H16N2O5 4-(Glutamylamino) butanoate 232.10593 Escherichia coli SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 2.0 O2 Oxygen 31.98983 4-aminobutyrate aminotransferase 1.0 P76149 UniProt 6.0 C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound 20148392 ChemSpider C00624 KEGG Compound SMILES [NH4+] PW000791 PathWhiz NAD+-dependent succinate semialdehyde dehydrogenase 4-aminobutyrate aminotransferase_ 1.0 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI 7782-44-7 CAS P23883 UniProt SubPathwayInteraction92982 SubPathwayReaction SubPathway92982Reaction Succinic acid SubPathwayInput 1.0 N-ALPHA-ACETYLORNITHINE BioCyc CHEBI:15366 ChEBI 4-aminobutyrate aminotransferase 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O SMILES CC(=O)N[C@@H](CCCN)C(O)=O 1.0 1.0 2.0 5893 PubChem-compound 110-15-6 CAS Gamma-aminobutyraldehyde dehydrogenase 439232 PubChem-compound 171 ChemSpider SubPathwayInteraction92931 SubPathway92931Reaction SubPathwayReaction CHEBI:15377 ChEBI 2.0 CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] N-ACETYL-GLUTAMYL-P BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1045 PubChem-compound 1.0 1.0 1.0 280 PubChem-compound CHEBI:17769 ChEBI 56-12-2 CAS Ornithine decarboxylase, inducible 16741146 PubChem-compound Acetylornithine deacetylase 389220 ChemSpider 185 PubChem-compound Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 20841830 PubChem-compound 1.0 2.6.1.82 false 2.6.1.82 Oxoglutaric acid + Putrescine → 4-Aminobutyraldehyde + L-Glutamic acid LEFT_TO_RIGHT 1.2.1.5 false 1.2.1.5 4-(γ-glutamylamino)butanal + NADP + Water → 4-(Glutamylamino) butanoate + 2 Hydrogen Ion + NADPH LEFT_TO_RIGHT 3.5.1.94 false 3.5.1.94 4-(Glutamylamino) butanoate + Water → L-Glutamic acid + gamma-Aminobutyric acid LEFT_TO_RIGHT 6.3.1.11 false 6.3.1.11 Adenosine triphosphate + L-Glutamic acid + Putrescine → Adenosine diphosphate + Gamma-glutamyl-L-putrescine + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 1.4.3.- false 1.4.3.- Gamma-glutamyl-L-putrescine + Oxygen + Water → 4-(γ-glutamylamino)butanal + Ammonium + Hydrogen peroxide LEFT_TO_RIGHT 2.0 P77674 UniProt 1061 PubChem-compound 1.0 4-aminobutyrate aminotransferase HMDB0001967 HMDB CHEBI:15351 ChEBI Gamma-aminobutyraldehyde dehydrogenase N-acetyl-gamma-glutamyl-phosphate reductase Gamma-glutamylputrescine synthetase 440236 PubChem-compound 176 PubChem-compound 1.2.1.38 false 1.2.1.38 Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH → N-acetylglutamate semialdehyde + NADP + Phosphate LEFT_TO_RIGHT C9H19N3O3 Gamma-glutamyl-L-putrescine 217.14264 Reaction2670 false Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetylglutamic acid LEFT_TO_RIGHT Gamma-glutamyl-L-putrescine 2.7.2.8 false 2.7.2.8 Adenosine triphosphate + N-Acetylglutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate LEFT_TO_RIGHT P42588 UniProt 85-61-0 CAS L-ORNITHINE BioCyc 180 ChemSpider CHEBI:48005 ChEBI Unknown Acetylglutamate kinase N-acetyl- gamma- glutamyl- phosphate reductase Gamma- glutamylputrescine synthetase Gamma- glutamylputrescine oxidoreductase Gamma- glutamyl- gamma- aminobutyraldehyde dehydrogenase Gamma- glutamyl- gamma- aminobutyrate hydrolase Putrescine aminotransferase Succinate- semialdehyde dehydrogenase [NADP+] Acetylornithine deacetylase Aldehyde dehydrogenase- like protein yneI 4-aminobutyrate aminotransferase_ 4-aminobutyrate aminotransferase Gamma- aminobutyraldehyde dehydrogenase Ornithine decarboxylase, inducible Acetylornithine/succinyldiaminopimelate aminotransferase Succinic acid Acetyl-CoA L-Glutamic acid CoA H + N- Acetylglutamic acid ATP ADP N-Acetyl-L- glutamyl 5-phosphate NADPH H + N- acetylglutamate semialdehyde P i NADP Putrescine ATP L-Glutamic acid P i ADP H + Gamma- glutamyl-L- putrescine O 2 H 2 O 4-(γ- glutamylamino)butanal Ammonium H 2 O 2 H 2 O NADP 4- (Glutamylamino) butanoate H + NADPH H 2 O L-Glutamic acid gamma- Aminobutyric acid Oxoglutaric acid L-Glutamic acid 4- Aminobutyraldehyde Succinic acid semialdehyde H 2 O NADP NADPH H + N- Acetylornithine H 2 O Ornithine Acetic acid NAD H 2 O H + NADH Oxoglutaric acid L-Glutamic acid H 2 O NAD H + NADH H + CO 2 L-Glutamic acid Oxoglutaric acid TCA Cycle Glycolysis and Pyruvate Dehydrogenase
CHEBI:16015 ChEBI C00437 KEGG Compound 6022 PubChem-compound 7722-84-1 CAS 2.0 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 1.0 937 ChemSpider Succinic acid semialdehyde C00555 KEGG Compound Succinate-semialdehyde dehydrogenase [NADP+] 4-AMINO-BUTYRALDEHYDE BioCyc HMDB0003125 HMDB 1.0 439153 PubChem-compound 1.0 50 ChemSpider 1.0 388369 ChemSpider 4-Aminobutyraldehyde ornithine decarboxylase ATP BioCyc H4N Ammonium 18.034374 CHEBI:16265 ChEBI Reaction2694 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT 4.1.1.17 false 4.1.1.17 Hydrogen Ion + Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 1.0 1.2.1.79 false 1.2.1.79 NADP + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADPH + Succinic acid LEFT_TO_RIGHT 1.2.1.16 false 1.2.1.16 NAD + Succinic acid semialdehyde + Water → 2 Hydrogen Ion + NADH + Succinic acid LEFT_TO_RIGHT SMILES NCCCCNC(=O)CC[C@H](N)C(O)=O 1.2.1.19 false 1.2.1.19 4-Aminobutyraldehyde + NAD + Water → Hydrogen Ion + NADH + gamma-Aminobutyric acid LEFT_TO_RIGHT 2.6.1.19 false 2.6.1.19 Oxoglutaric acid + gamma-Aminobutyric acid → L-Glutamic acid + Succinic acid semialdehyde LEFT_TO_RIGHT P23908 UniProt 1.0 HMDB0001080 HMDB 5742 ChemSpider NADH C00334 KEGG Compound CHEBI:16474 ChEBI 952 ChemSpider Acetylglutamate kinase Gamma-glutamylputrescine oxidoreductase P18335 UniProt Acetyl-CoA CHEBI:16240 ChEBI Aldehyde dehydrogenase-like protein yneI 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS SMILES NCCCCN 23724570 PubChem-compound 1.0 5105-96-4 CAS 2.0 CHEBI:17148 ChEBI Ammonium Hydrogen Ion Putrescine aminotransferase C00232 KEGG Compound Cytosol 1.0 Adenosine triphosphate SUC BioCyc Acetylornithine/succinyldiaminopimelate aminotransferase CHEBI:49260 ChEBI Gamma-glutamyl-gamma-aminobutyrate hydrolase C00009 KEGG Compound C00008 KEGG Compound 110-60-1 CAS C00007 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI Hydrogen Ion C00001 KEGG Compound N-Acetylornithine C00005 KEGG Compound CPD-9000 BioCyc 2.0 CHEBI:18367 ChEBI C00004 KEGG Compound N-Acetylglutamic acid 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 6205-08-9 CAS Glycolysis and Pyruvate Dehydrogenase SubPathway C21H28N7O14P2 NAD 664.11694 1.0 TCA Cycle SubPathway C01342 KEGG Compound C00011 KEGG Compound C00010 KEGG Compound HMDB0000902 HMDB 1.0 C4H9NO 4-Aminobutyraldehyde 87.06841 C00134 KEGG Compound 4.0 Q86WD1 UniProt NAD(P) BioCyc HMDB0006456 HMDB 562 TAXONOMY 1.0 H Hydrogen Ion 1.007825 Ornithine Metabolism C4H6O3 Succinic acid semialdehyde 102.03169 56-65-5 CAS 53-84-9 CAS C00027 KEGG Compound L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound ACET BioCyc ReactionCatalysis153673 ACTIVATION 1.0 1.0 PUTRESCINE BioCyc SMP0000802 SMPDB 1.0 C00033 KEGG Compound SMP0000807 SMPDB HMDB0012230 HMDB 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000254 HMDB Water Hydrogen peroxide SMILES OC(=O)CCC(O)=O HYDROGEN-PEROXIDE BioCyc P50457 UniProt P24169 UniProt 4-aminobutyrate aminotransferase_ C15767 KEGG Compound HMDB0001341 HMDB SMP0000813 SMPDB N-Acetyl-L-glutamyl 5-phosphate C00042 KEGG Compound Acetylornithine deacetylase N-Acetylornithine SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 763 ChemSpider CREB3L2-PPARgamma HMDB0000148 HMDB Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1.0 succinate-semialdehyde dehydrogenase (NADP+) 784 PubChem-compound 1.0 C7H11NO5 N-Acetylglutamic acid 189.06372 4390-05-0 CAS Ornithine decarboxylase, inducible SMILES CC(O)=O 7732-18-5 CAS C7H14N2O3 N-Acetylornithine 174.10045 N-acetyl-gamma-glutamyl-phosphate reductase HMDB0001487 HMDB 56-86-0 CAS 1.0 NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 1.0 N-acetylglutamate semialdehyde 1.0 acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase HMDB0001377 HMDB HMDB0001138 HMDB HMDB0001259 HMDB Succinate-semialdehyde dehydrogenase [NADP+] HMDB0000042 HMDB 962 PubChem-compound 5800 ChemSpider C00077 KEGG Compound CO2 Carbon dioxide 43.98983 SMILES N[C@@H](CCC(=O)NCCCC(O)=O)C(O)=O Phosphate C00080 KEGG Compound SMILES O=O Oxoglutaric acid 15383-57-0 CAS SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0002111 HMDB 14265-44-2 CAS 58-64-0 CAS HMDB0012161 HMDB Putrescine C15699 KEGG Compound 444493 PubChem-compound C7H12NO8P N-Acetyl-L-glutamyl 5-phosphate 269.03006 22833512 PubChem-compound ACETYL-COA BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 4-AMINO-BUTYRATE BioCyc 4-Aminobutyraldehyde NADH BioCyc Gamma-glutamylputrescine oxidoreductase 1.0 SMILES NCCCC(O)=O NAD BioCyc SMILES CC(=O)N[C@@H](CCC(O)=O)C(O)=O 977 PubChem-compound HMDB0059597 HMDB HMDB0041827 HMDB 1.0 Acetylornithine/succinyldiaminopimelate aminotransferase SMILES NC(CCC(=O)NCCCC=O)C([O-])=O 21865667 ChemSpider 1.0 HMDB0003357 HMDB Reaction163303 false N-acetylglutamate semialdehyde + L-Glutamic acid → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT 30572 ChemSpider 17215925 ChemSpider CHEBI:12575 ChEBI C2H4O2 Acetic acid 60.02113 P78061 UniProt SMILES CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O Succinic acid γ-aminobutyraldehyde dehydrogenase 64-19-7 CAS 13837702 ChemSpider SMILES O SMILES OO Acetyl-CoA SubPathwayOutput Succinic acid semialdehyde 2.0 119 PubChem-compound 118 PubChem-compound HMDB0000538 HMDB C7H11NO5 N-acetylglutamate semialdehyde 189.06372 C9H15N2O4 4-(γ-glutamylamino)butanal 215.10373 ReactionCatalysis2665 ACTIVATION 1.0 C04133 KEGG Compound CHEBI:61508 ChEBI P25526 UniProt 6816 PubChem-compound P22256 UniProt 51 PubChem-compound CHEBI:15846 ChEBI ADP BioCyc 1.0 CHEBI:15729 ChEBI ReactionCatalysis2664 ACTIVATION ReactionCatalysis2663 ACTIVATION 53-59-8 CAS 1.0 acetylornithine deacetylase 1038 PubChem-compound acetylglutamate kinase N-acetylglutamate synthase GO:0005829 GENE ONTOLOGY ReactionCatalysis2679 ACTIVATION ReactionCatalysis2678 ACTIVATION 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 CHEBI:16908 ChEBI 70-26-8 CAS Aldehyde dehydrogenase-like protein yneI O4P Phosphate 94.95342 GLUTAMINE-PUTRESCINE LIGASE γ-glutamyl-γ-aminobutyrate hydrolase NADPH 6026 ChemSpider Acetic acid ReactionCatalysis2688 ACTIVATION ReactionCatalysis2687 ACTIVATION Ornithine HMDB0001414 HMDB NADP C21H30N7O17P3 NADPH 745.0911 ReactionCatalysis2680 ACTIVATION ReactionCatalysis2682 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis2681 ACTIVATION ReactionCatalysis2684 ACTIVATION ReactionCatalysis2683 ACTIVATION C5H12N2O2 Ornithine 132.08987 ReactionCatalysis2686 ACTIVATION ReactionCatalysis2685 ACTIVATION NADPH BioCyc P11446 UniProt 6857435 PubChem-compound Gamma-glutamylputrescine synthetase PW000785 PathWhiz gamma-Aminobutyric acid HMDB0000208 HMDB Carbon dioxide CPD-6641 BioCyc GAMMA-GLUTAMYL-PUTRESCINE BioCyc 218 ChemSpider 58-68-4 CAS C4H9NO2 gamma-Aminobutyric acid 103.06333 L-Glutamic acid HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O HMDB0000214 HMDB HMDB0000217 HMDB SMILES OC(=O)CCC(=O)C(O)=O Oxygen 692-29-5 CAS CHEBI:30915 ChEBI 124-38-9 CAS PW000779 PathWhiz CHEBI:16865 ChEBI ACETYL-GLU BioCyc HMDB0001429 HMDB 4-(Glutamylamino) butanoate 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 1.0 GLT BioCyc CREB3L2-PPARgamma 4.0 53-57-6 CAS CHEBI:15741 ChEBI Oxoglutaric acid 1.0 1.0 4-(γ-glutamylamino)butanal 1112 PubChem-compound SMILES O=C=O CHEBI:28938 ChEBI N-acetylglutamate semialdehyde 12.0 1110 PubChem-compound HMDB0000112 HMDB 116 ChemSpider 115 ChemSpider C21H29N7O14P2 NADH 665.12476 HMDB0001206 HMDB 5957 PubChem-compound 1188-37-0 CAS gamma-Aminobutyric acid C4H6O4 Succinic acid 118.02661 Acetylglutamate kinase Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES NCCCC=O SUCC-S-ALD BioCyc CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 2.0 5682 ChemSpider CHEBI:1146900 ChEBI SMILES OC(=O)CCC=O CHEBI:16543 ChEBI CO-A BioCyc Putrescine aminotransferase Gamma-glutamyl-gamma-aminobutyrate hydrolase 5675 ChemSpider 72-89-9 CAS 1078 ChemSpider Ornithine P37906 UniProt Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 14798-03-9 CAS 1080 ChemSpider Putrescine 1.0 P76038 UniProt C4H12N2 Putrescine 88.10005 CHEBI:15422 ChEBI 6557 ChemSpider CHEBI:16878 ChEBI P0A6C8 UniProt C9H16N2O5 4-(Glutamylamino) butanoate 232.10593 Escherichia coli SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 2.0 O2 Oxygen 31.98983 4-aminobutyrate aminotransferase 1.0 P76149 UniProt 6.0 C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound 20148392 ChemSpider C00624 KEGG Compound SMILES [NH4+] PW000791 PathWhiz NAD+-dependent succinate semialdehyde dehydrogenase 4-aminobutyrate aminotransferase_ 1.0 1.0 CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI 7782-44-7 CAS P23883 UniProt SubPathwayInteraction92982 SubPathwayReaction SubPathway92982Reaction Succinic acid SubPathwayInput 1.0 N-ALPHA-ACETYLORNITHINE BioCyc CHEBI:15366 ChEBI 4-aminobutyrate aminotransferase 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O SMILES CC(=O)N[C@@H](CCCN)C(O)=O 1.0 1.0 2.0 5893 PubChem-compound 110-15-6 CAS Gamma-aminobutyraldehyde dehydrogenase 439232 PubChem-compound 171 ChemSpider SubPathwayInteraction92931 SubPathway92931Reaction SubPathwayReaction CHEBI:15377 ChEBI 2.0 CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] N-ACETYL-GLUTAMYL-P BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1045 PubChem-compound 1.0 1.0 1.0 280 PubChem-compound CHEBI:17769 ChEBI 56-12-2 CAS Ornithine decarboxylase, inducible 16741146 PubChem-compound Acetylornithine deacetylase 389220 ChemSpider 185 PubChem-compound Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 20841830 PubChem-compound 1.0 2.6.1.82 false 2.6.1.82 Oxoglutaric acid + Putrescine → 4-Aminobutyraldehyde + L-Glutamic acid LEFT_TO_RIGHT 1.2.1.5 false 1.2.1.5 4-(γ-glutamylamino)butanal + NADP + Water → 4-(Glutamylamino) butanoate + 2 Hydrogen Ion + NADPH LEFT_TO_RIGHT 3.5.1.94 false 3.5.1.94 4-(Glutamylamino) butanoate + Water → L-Glutamic acid + gamma-Aminobutyric acid LEFT_TO_RIGHT 6.3.1.11 false 6.3.1.11 Adenosine triphosphate + L-Glutamic acid + Putrescine → Adenosine diphosphate + Gamma-glutamyl-L-putrescine + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 1.4.3.- false 1.4.3.- Gamma-glutamyl-L-putrescine + Oxygen + Water → 4-(γ-glutamylamino)butanal + Ammonium + Hydrogen peroxide LEFT_TO_RIGHT 2.0 P77674 UniProt 1061 PubChem-compound 1.0 4-aminobutyrate aminotransferase HMDB0001967 HMDB CHEBI:15351 ChEBI Gamma-aminobutyraldehyde dehydrogenase N-acetyl-gamma-glutamyl-phosphate reductase Gamma-glutamylputrescine synthetase 440236 PubChem-compound 176 PubChem-compound 1.2.1.38 false 1.2.1.38 Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH → N-acetylglutamate semialdehyde + NADP + Phosphate LEFT_TO_RIGHT C9H19N3O3 Gamma-glutamyl-L-putrescine 217.14264 Reaction2670 false Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetylglutamic acid LEFT_TO_RIGHT Gamma-glutamyl-L-putrescine 2.7.2.8 false 2.7.2.8 Adenosine triphosphate + N-Acetylglutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate LEFT_TO_RIGHT P42588 UniProt 85-61-0 CAS L-ORNITHINE BioCyc 180 ChemSpider CHEBI:48005 ChEBI