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Pathway Description
D-Allulose Degradation
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-03-27
Last Updated: 2019-09-03
D-allose can be used as source of carbon for E.coli. D-allose is imported into E.coli by D-allose ABC transporter without phosphorylation. Allose-6-phosphate isomerase and allulose-6-phosphate 3-epimerase catalyze the remaining reactions resulting in D-allulose 6 phosphate and Beta-D-fructofuranose 6-phosphate respectively. Once Beta D fructofuranose 6-phosphate is synthesized, it can be used in the glycolysis and pyruvatedehydrogenase pathway.
References
D-Allulose Degradation References
Chan KK, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA: Structural basis for substrate specificity in phosphate binding (beta/alpha)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12. Biochemistry. 2008 Sep 9;47(36):9608-17. doi: 10.1021/bi800821v. Epub 2008 Aug 14.
Pubmed: 18700786
Kim C, Song S, Park C: The D-allose operon of Escherichia coli K-12. J Bacteriol. 1997 Dec;179(24):7631-7.
Pubmed: 9401019
Miller BG, Raines RT: Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Biochemistry. 2005 Aug 16;44(32):10776-83. doi: 10.1021/bi0506268.
Pubmed: 16086580
Poulsen TS, Chang YY, Hove-Jensen B: D-Allose catabolism of Escherichia coli: involvement of alsI and regulation of als regulon expression by allose and ribose. J Bacteriol. 1999 Nov;181(22):7126-30.
Pubmed: 10559180
Roos AK, Mariano S, Kowalinski E, Salmon L, Mowbray SL: D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not. J Mol Biol. 2008 Oct 10;382(3):667-79. doi: 10.1016/j.jmb.2008.06.090. Epub 2008 Jul 9.
Pubmed: 18640127
Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. doi: 10.1093/nar/23.12.2105.
Pubmed: 7610040
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Blattner FR, Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL: Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Nucleic Acids Res. 1993 Nov 25;21(23):5408-17. doi: 10.1093/nar/21.23.5408.
Pubmed: 8265357
Sorensen KI, Hove-Jensen B: Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression. J Bacteriol. 1996 Feb;178(4):1003-11. doi: 10.1128/jb.178.4.1003-1011.1996.
Pubmed: 8576032
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