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Pathway Description
beta-Alanine Metabolism
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-05-13
Last Updated: 2024-12-28
Beta-Alanine metabolism starts as a product of aspartate metabolism. Aspartate is decarboxylated by aspartate 1-decarboxylase, releasing carbon dioxide and beta-alanine. Beta-Alanine is then metabolized through a pantothenate synthease resulting in pantothenic acid. Pantothenic acid then undergoes phosphorylation through an ATP-driven pantothenate kinase, resulting in D-4-phosphopantothenate. Pantothenate, vitamin B5, is a precursor for synthesis of 4'-phosphopantetheine moiety of coenzyme A and acyl carrier protein. Plants and microorganisms can synthesize pantothenate de novo, but animals must obtain it from diet. Enzymes of beta-alanine metabolism are targets for anti-microbial drugs.
References
beta-Alanine Metabolism References
Cronan JE Jr, Littel KJ, Jackowski S: Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1982 Mar;149(3):916-22.
Pubmed: 7037743
Cronan JE Jr: Beta-alanine synthesis in Escherichia coli. J Bacteriol. 1980 Mar;141(3):1291-7.
Pubmed: 6767707
Merkel WK, Nichols BP: Characterization and sequence of the Escherichia coli panBCD gene cluster. FEMS Microbiol Lett. 1996 Oct 1;143(2-3):247-52. doi: 10.1016/0378-1097(96)00321-7.
Pubmed: 8837478
Fujita N, Mori H, Yura T, Ishihama A: Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region. Nucleic Acids Res. 1994 May 11;22(9):1637-9. doi: 10.1093/nar/22.9.1637.
Pubmed: 8202364
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000915
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