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PW000981 PathWhiz C5H11O7P 1-Deoxy-D-xylulose 5-phosphate 214.02425 17215925 ChemSpider 6022 PubChem-compound 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 937 ChemSpider Isopentenyl-diphosphate Delta-isomerase CHEBI:16493 ChEBI 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Cytidine triphosphate SMILES O HMDB0000095 HMDB CHEBI:57919 ChEBI 2.0 Pyrophosphate 1.0 C00448 KEGG Compound 6131 PubChem-compound P0AD57 UniProt 1.0 1.0 HMDB0000538 HMDB ATP BioCyc 1.0 393270 ChemSpider 559142 ChemSpider 5.0 ADP BioCyc P22939 UniProt 53-59-8 CAS 1.0 358-72-5 CAS 1-deoxyxylulose-5-phosphate synthase 1.0 5742 ChemSpider 1038 PubChem-compound 4444251 ChemSpider CHEBI:16474 ChEBI 2.5.1.10 false 2.5.1.10 Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate LEFT_TO_RIGHT 5.3.3.2 false 5.3.3.2 Isopentenyl pyrophosphate ↔ Dimethylallylpyrophosphate REVERSIBLE Reaction3694 false 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Dimethylallylpyrophosphate + NADP + Water LEFT_TO_RIGHT 1.17.1.2 false 1.17.1.2 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Isopentenyl pyrophosphate + NADPH + Water LEFT_TO_RIGHT 1.17.7.1 false 1.17.7.1 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + a reduced flavodoxin → 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + Water + an oxidized flavodoxin LEFT_TO_RIGHT 4.6.1.12 false 4.6.1.12 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate LEFT_TO_RIGHT 2.7.1.148 false 2.7.1.148 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate → 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine diphosphate + Hydrogen Ion LEFT_TO_RIGHT 274 ChemSpider Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis SubPathway Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis 2.5.1.90 false 2.5.1.90 Farnesyl pyrophosphate + 5 Isopentenyl pyrophosphate → Octaprenyl diphosphate + 5 Pyrophosphate LEFT_TO_RIGHT PW000959 PathWhiz PW000958 PathWhiz 2.5.1.31 false 2.5.1.31 Farnesyl pyrophosphate + 8 Isopentenyl pyrophosphate → 8 Pyrophosphate + di-trans,octa-cis-undecaprenyl diphosphate LEFT_TO_RIGHT Reaction3697 false Geranyl-PP + Isopentenyl pyrophosphate → Farnesyl pyrophosphate + Pyrophosphate LEFT_TO_RIGHT 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate CHEBI:58483 ChEBI 709 ChemSpider C00341 KEGG Compound C14H23N3O14P2 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 519.06665 NADPH C5H10O9P2 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate 275.98 CHEBI:17211 ChEBI C04146 KEGG Compound 1-Deoxy-D-xylulose 5-phosphate C14H22N3O17P3 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 597.0184 445713 PubChem-compound 1010 ChemSpider CHEBI:57823 ChEBI NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 HMDB0001094 HMDB C21H29N7O17P3 NADP 744.08325 2.7.7.60 false 2.7.7.60 2-C-methyl-D-erythritol 4-phosphate + Cytidine triphosphate + Hydrogen Ion → 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Pyrophosphate LEFT_TO_RIGHT 1.1.1.267 false 1.1.1.267 1-Deoxy-D-xylulose 5-phosphate + Hydrogen Ion + NADPH → 2-C-methyl-D-erythritol 4-phosphate + NADP LEFT_TO_RIGHT 63-37-6 CAS Reaction3687 false D-Glyceraldehyde 3-phosphate + Hydrogen Ion → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide LEFT_TO_RIGHT C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 2.0 1.0 NADPH BioCyc Hydrogen Ion 8.0 PW000785 PathWhiz SMILES [H][C@@](O)(COP(O)(O)=O)[C@@](C)(O)CO C5H12O7P2 Isopentenyl pyrophosphate 246.00583 8.0 C00235 KEGG Compound CHEBI:16057 ChEBI Adenosine triphosphate HMDB0000217 HMDB 1.0 C10H20O7P2 Geranyl-PP 314.06842 124-38-9 CAS 2.0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase C00008 KEGG Compound C00129 KEGG Compound 1158 ChemSpider C00006 KEGG Compound SMP0000975 SMPDB Isopentenyl-diphosphate Delta-isomerase CHEBI:18009 ChEBI C5H12O7P2 Dimethylallylpyrophosphate 246.00583 SMP0000974 SMPDB C00001 KEGG Compound CTP BioCyc CHEBI:18361 ChEBI C00005 KEGG Compound an oxidized flavodoxin SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/COP(O)(=O)OP(O)(O)=O Farnesyl pyrophosphate C00002 KEGG Compound a reduced flavodoxin SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 3.0 1.0 1.0 393471 ChemSpider 53-57-6 CAS an oxidized flavodoxin a reduced flavodoxin Glycolysis and Pyruvate Dehydrogenase SubPathway 2.0 Peptidoglycan Biosynthesis I SubPathway 763-10-0 CAS CHEBI:17361 ChEBI C00011 KEGG Compound SMILES O=C=O Dimethylallylpyrophosphate 443201 PubChem-compound Geranyl-PP CHEBI:16275 ChEBI C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 NAD(P) BioCyc Q46893 UniProt 1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 UniProt 5957 PubChem-compound CHEBI:128753 ChEBI C9H16N3O14P3 Cytidine triphosphate 482.9845 562 TAXONOMY CHEBI:17138 ChEBI H Hydrogen Ion 1.007825 D-Glyceraldehyde 3-phosphate SMP0000997 SMPDB SubPathwayInteraction1675 SubPathway1675Reaction SubPathwayReaction 445995 PubChem-compound 56-65-5 CAS SubPathwayInteraction1676 SubPathway1676Reaction SubPathwayReaction Isopentenyl pyrophosphate Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) Cytidine monophosphate SubPathwayInteraction2097 SubPathwayReaction SubPathway2097Reaction DEOXYXYLULOSE-5P BioCyc Adenosine diphosphate HMDB0001213 HMDB C10H15N5O10P2 Adenosine diphosphate 427.02942 Octaprenyl diphosphate C40H68O7P2 Octaprenyl diphosphate 722.44403 1.0 Octaprenyl-diphosphate synthase C9H14N3O8P Cytidine monophosphate 323.05185 1.0 SMP0000924 SMPDB SubPathwayInteraction1726 SubPathway1726Reaction SubPathwayReaction 647 PubChem-compound 372-97-4 CAS SMP0000807 SMPDB 2.0 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4-diphosphocytidyl-2C-methyl-D-erythritol synthase Water 4-diphosphocytidyl-2-C-methylerythritol kinase HMDB0001347 HMDB SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Geranyltranstransferase octaprenyl diphosphate synthase HMDB0000250 HMDB undecaprenyl diphosphate synthase SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase 14000-31-8 CAS HMDB0001341 HMDB GERANYL-PP BioCyc SMILES [H][C@@]1(O)COP([O-])(=O)OP([O-])(=O)O[C@@]1(C)CO 5675 ChemSpider SMILES [H][C@@](O)(COP(O)(=O)OP([O-])(=O)OC[C@@]1([H])O[C@@]([H])(N2C=CC(=N)N=C2[O-])[C@]([H])(O)[C@]1([H])O)[C@@](C)(O)CO SMILES [H][C@@](O)(COP(O)(=O)OP([O-])(=O)OC[C@@]1([H])O[C@@]([H])(N2C=CC(=N)N=C2[O-])[C@]([H])(O)[C@]1([H])O)[C@](C)(CO)OP([O-])([O-])=O SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001112 HMDB SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O P77488 UniProt 1-deoxy-D-xylulose-5-phosphate synthase 5901 ChemSpider C15H28O7P2 Farnesyl pyrophosphate 382.131 CHEBI:15422 ChEBI 1.0 5.0 SMILES [H]\C(COP([O-])(=O)OP([O-])([O-])=O)=C(\C)CO C00055 KEGG Compound Escherichia coli 1.0 7732-18-5 CAS P60472 UniProt 591-59-3 CAS SMILES CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1.0 C00063 KEGG Compound 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1.0 HMDB0001120 HMDB CPD-4211 BioCyc C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:16526 ChEBI 1-deoxy-D-xylulose 5-phosphate reductoisomerase FARNESYL-PP BioCyc CHEBI:16761 ChEBI 65-47-4 CAS HMDB0000961 HMDB 5280651 PubChem-compound 1.0 Octaprenyl-diphosphate synthase 391473 ChemSpider 962 PubChem-compound C5H9O8P2 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate 258.97726 358-71-4 CAS 5800 ChemSpider CO2 Carbon dioxide 43.98983 1.0 di-trans,octa-cis-undecaprenyl diphosphate SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O ReactionCatalysis3668 ACTIVATION CMP BioCyc C00080 KEGG Compound ReactionCatalysis3669 ACTIVATION ReactionCatalysis3666 ACTIVATION ReactionCatalysis3667 ACTIVATION 729 PubChem-compound Secondary Metabolites: Ubiquinol Biosynthesis SubPathway ReactionCatalysis3664 ACTIVATION HMDB0002111 HMDB ReactionCatalysis3665 ACTIVATION CHEBI:17677 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] 6176 PubChem-compound 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2-C-methyl-D-erythritol 4-phosphate Q46822 UniProt Geranyltranstransferase CHEBI:16584 ChEBI 1-deoxy-D-xylulose-5-phosphate synthase 1.0 190079-18-6 CAS 280 PubChem-compound ReactionCatalysis3671 ACTIVATION ReactionCatalysis3672 ACTIVATION ReactionCatalysis3670 ACTIVATION ReactionCatalysis3675 ACTIVATION ReactionCatalysis3676 ACTIVATION ReactionCatalysis3673 ACTIVATION 1.0 ReactionCatalysis3674 ACTIVATION P62617 UniProt 1.0 P62615 UniProt 644102 PubChem-compound 1195 PubChem-compound 5941 ChemSpider CHEBI:17407 ChEBI Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) SMILES CC(=C)CCO[P@](O)(=O)OP(O)(O)=O C5H13O7P 2-C-methyl-D-erythritol 4-phosphate 216.03989 SMILES OC(COP(O)(O)=O)C=O 22833512 PubChem-compound H2O Water 18.010565 SMILES CC(C)=CCC\C(C)=C\CO[P@@](=O)(O)OP(=O)(O)O 1.0 1.0 HMDB0001285 HMDB 1.0 GAP BioCyc HMDB0059597 HMDB 2.0 P62623 UniProt C00661 KEGG Compound Carbon dioxide P62620 UniProt C55H92O7P2 di-trans,octa-cis-undecaprenyl diphosphate 926.63184 HMDB0001967 HMDB 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 627 ChemSpider SMILES CC(C)=CCO[P@](O)(=O)OP(O)(O)=O 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase C11437 KEGG Compound PW000906 PathWhiz 1-deoxy-D-xylulose 5-phosphate reductoisomerase HMDB0000082 HMDB 2.0 OCTAPRENYL-DIPHOSPHATE BioCyc 1-deoxy-D- xylulose-5- phosphate synthase 1-deoxy-D- xylulose 5-phosphate reductoisomerase 2-C-methyl-D- erythritol 4-phosphate cytidylyltransferase 4- diphosphocytidyl- 2-C-methyl-D- erythritol kinase 2-C-methyl-D- erythritol 2,4- cyclodiphosphate synthase 4-hydroxy-3- methylbut-2- en-1-yl diphosphate synthase 4-hydroxy-3- methylbut-2- enyl diphosphate reductase 4-hydroxy-3- methylbut-2- enyl diphosphate reductase Isopentenyl- diphosphate Delta-isomerase Geranyltranstransferase Geranyltranstransferase Ditrans,polycis- undecaprenyl- diphosphate synthase ((2E,6E)- farnesyl- diphosphate specific) Octaprenyl- diphosphate synthase D- Glyceraldehyde 3-phosphate H + CO 2 1-Deoxy-D- xylulose 5-phosphate NADPH H + NADP 2-C-methyl-D- erythritol 4-phosphate Cytidine triphosphate H + PP i 4-(cytidine 5'- diphospho)-2- C-methyl-D- erythritol ATP ADP H + 2-phospho-4- (cytidine 5'- diphospho)-2- C-methyl-D- erythritol Cytidine monophosphate 2-C-Methyl-D- erythritol- 2,4- cyclodiphosphate H 2 O H + 1-hydroxy-2- methyl-2-(E)- butenyl 4-diphosphate H + NADPH H 2 O NADPH Isopentenyl pyrophosphate H + NADPH NADP H 2 O Dimethylallylpyrophosphate Dimethylallylpyrophosphate Isopentenyl pyrophosphate PP i Geranyl-PP Isopentenyl pyrophosphate PP i Farnesyl pyrophosphate Isopentenyl pyrophosphate PP i di- trans,octa- cis- undecaprenyl diphosphate Isopentenyl pyrophosphate PP i Octaprenyl diphosphate Manganese NADPH Magnesium Magnesium Manganese 4Fe-4S Manganese Cobalt FAD NADH NADPH Cobalt FAD NADPH Magnesium Zinc (II) ion Magnesium Magnesium Magnesium Magnesium a reduced flavodoxin an oxidized flavodoxin Glycolysis and Pyruvate Dehydrogenase Peptidoglycan Biosynthesis I Secondary Metabolites: Ubiquinol Biosynthesis Secondary Metabolites: Ubiquinol Biosynthesis Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis NADH
PW000981 PathWhiz C5H11O7P 1-Deoxy-D-xylulose 5-phosphate 214.02425 17215925 ChemSpider 6022 PubChem-compound 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 937 ChemSpider Isopentenyl-diphosphate Delta-isomerase CHEBI:16493 ChEBI 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Cytidine triphosphate SMILES O HMDB0000095 HMDB CHEBI:57919 ChEBI 2.0 Pyrophosphate 1.0 C00448 KEGG Compound 6131 PubChem-compound P0AD57 UniProt 1.0 1.0 HMDB0000538 HMDB ATP BioCyc 1.0 393270 ChemSpider 559142 ChemSpider 5.0 ADP BioCyc P22939 UniProt 53-59-8 CAS 1.0 358-72-5 CAS 1-deoxyxylulose-5-phosphate synthase 1.0 5742 ChemSpider 1038 PubChem-compound 4444251 ChemSpider CHEBI:16474 ChEBI 2.5.1.10 false 2.5.1.10 Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate LEFT_TO_RIGHT 5.3.3.2 false 5.3.3.2 Isopentenyl pyrophosphate ↔ Dimethylallylpyrophosphate REVERSIBLE Reaction3694 false 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Dimethylallylpyrophosphate + NADP + Water LEFT_TO_RIGHT 1.17.1.2 false 1.17.1.2 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Isopentenyl pyrophosphate + NADPH + Water LEFT_TO_RIGHT 1.17.7.1 false 1.17.7.1 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + a reduced flavodoxin → 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + Water + an oxidized flavodoxin LEFT_TO_RIGHT 4.6.1.12 false 4.6.1.12 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate LEFT_TO_RIGHT 2.7.1.148 false 2.7.1.148 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate → 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine diphosphate + Hydrogen Ion LEFT_TO_RIGHT 274 ChemSpider Secondary Metabolites: Enterobacterial Common Antigen Biosynthesis SubPathway Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis 2.5.1.90 false 2.5.1.90 Farnesyl pyrophosphate + 5 Isopentenyl pyrophosphate → Octaprenyl diphosphate + 5 Pyrophosphate LEFT_TO_RIGHT PW000959 PathWhiz PW000958 PathWhiz 2.5.1.31 false 2.5.1.31 Farnesyl pyrophosphate + 8 Isopentenyl pyrophosphate → 8 Pyrophosphate + di-trans,octa-cis-undecaprenyl diphosphate LEFT_TO_RIGHT Reaction3697 false Geranyl-PP + Isopentenyl pyrophosphate → Farnesyl pyrophosphate + Pyrophosphate LEFT_TO_RIGHT 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate CHEBI:58483 ChEBI 709 ChemSpider C00341 KEGG Compound C14H23N3O14P2 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 519.06665 NADPH C5H10O9P2 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate 275.98 CHEBI:17211 ChEBI C04146 KEGG Compound 1-Deoxy-D-xylulose 5-phosphate C14H22N3O17P3 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 597.0184 445713 PubChem-compound 1010 ChemSpider CHEBI:57823 ChEBI NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 HMDB0001094 HMDB C21H29N7O17P3 NADP 744.08325 2.7.7.60 false 2.7.7.60 2-C-methyl-D-erythritol 4-phosphate + Cytidine triphosphate + Hydrogen Ion → 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Pyrophosphate LEFT_TO_RIGHT 1.1.1.267 false 1.1.1.267 1-Deoxy-D-xylulose 5-phosphate + Hydrogen Ion + NADPH → 2-C-methyl-D-erythritol 4-phosphate + NADP LEFT_TO_RIGHT 63-37-6 CAS Reaction3687 false D-Glyceraldehyde 3-phosphate + Hydrogen Ion → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide LEFT_TO_RIGHT C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 2.0 1.0 NADPH BioCyc Hydrogen Ion 8.0 PW000785 PathWhiz SMILES [H][C@@](O)(COP(O)(O)=O)[C@@](C)(O)CO C5H12O7P2 Isopentenyl pyrophosphate 246.00583 8.0 C00235 KEGG Compound CHEBI:16057 ChEBI Adenosine triphosphate HMDB0000217 HMDB 1.0 C10H20O7P2 Geranyl-PP 314.06842 124-38-9 CAS 2.0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase C00008 KEGG Compound C00129 KEGG Compound 1158 ChemSpider C00006 KEGG Compound SMP0000975 SMPDB Isopentenyl-diphosphate Delta-isomerase CHEBI:18009 ChEBI C5H12O7P2 Dimethylallylpyrophosphate 246.00583 SMP0000974 SMPDB C00001 KEGG Compound CTP BioCyc CHEBI:18361 ChEBI C00005 KEGG Compound an oxidized flavodoxin SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/COP(O)(=O)OP(O)(O)=O Farnesyl pyrophosphate C00002 KEGG Compound a reduced flavodoxin SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 3.0 1.0 1.0 393471 ChemSpider 53-57-6 CAS an oxidized flavodoxin a reduced flavodoxin Glycolysis and Pyruvate Dehydrogenase SubPathway 2.0 Peptidoglycan Biosynthesis I SubPathway 763-10-0 CAS CHEBI:17361 ChEBI C00011 KEGG Compound SMILES O=C=O Dimethylallylpyrophosphate 443201 PubChem-compound Geranyl-PP CHEBI:16275 ChEBI C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 NAD(P) BioCyc Q46893 UniProt 1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 UniProt 5957 PubChem-compound CHEBI:128753 ChEBI C9H16N3O14P3 Cytidine triphosphate 482.9845 562 TAXONOMY CHEBI:17138 ChEBI H Hydrogen Ion 1.007825 D-Glyceraldehyde 3-phosphate SMP0000997 SMPDB SubPathwayInteraction1675 SubPathway1675Reaction SubPathwayReaction 445995 PubChem-compound 56-65-5 CAS SubPathwayInteraction1676 SubPathway1676Reaction SubPathwayReaction Isopentenyl pyrophosphate Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) Cytidine monophosphate SubPathwayInteraction2097 SubPathwayReaction SubPathway2097Reaction DEOXYXYLULOSE-5P BioCyc Adenosine diphosphate HMDB0001213 HMDB C10H15N5O10P2 Adenosine diphosphate 427.02942 Octaprenyl diphosphate C40H68O7P2 Octaprenyl diphosphate 722.44403 1.0 Octaprenyl-diphosphate synthase C9H14N3O8P Cytidine monophosphate 323.05185 1.0 SMP0000924 SMPDB SubPathwayInteraction1726 SubPathway1726Reaction SubPathwayReaction 647 PubChem-compound 372-97-4 CAS SMP0000807 SMPDB 2.0 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4-diphosphocytidyl-2C-methyl-D-erythritol synthase Water 4-diphosphocytidyl-2-C-methylerythritol kinase HMDB0001347 HMDB SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Geranyltranstransferase octaprenyl diphosphate synthase HMDB0000250 HMDB undecaprenyl diphosphate synthase SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase 14000-31-8 CAS HMDB0001341 HMDB GERANYL-PP BioCyc SMILES [H][C@@]1(O)COP([O-])(=O)OP([O-])(=O)O[C@@]1(C)CO 5675 ChemSpider SMILES [H][C@@](O)(COP(O)(=O)OP([O-])(=O)OC[C@@]1([H])O[C@@]([H])(N2C=CC(=N)N=C2[O-])[C@]([H])(O)[C@]1([H])O)[C@@](C)(O)CO SMILES [H][C@@](O)(COP(O)(=O)OP([O-])(=O)OC[C@@]1([H])O[C@@]([H])(N2C=CC(=N)N=C2[O-])[C@]([H])(O)[C@]1([H])O)[C@](C)(CO)OP([O-])([O-])=O SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001112 HMDB SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O P77488 UniProt 1-deoxy-D-xylulose-5-phosphate synthase 5901 ChemSpider C15H28O7P2 Farnesyl pyrophosphate 382.131 CHEBI:15422 ChEBI 1.0 5.0 SMILES [H]\C(COP([O-])(=O)OP([O-])([O-])=O)=C(\C)CO C00055 KEGG Compound Escherichia coli 1.0 7732-18-5 CAS P60472 UniProt 591-59-3 CAS SMILES CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1.0 C00063 KEGG Compound 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1.0 HMDB0001120 HMDB CPD-4211 BioCyc C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:16526 ChEBI 1-deoxy-D-xylulose 5-phosphate reductoisomerase FARNESYL-PP BioCyc CHEBI:16761 ChEBI 65-47-4 CAS HMDB0000961 HMDB 5280651 PubChem-compound 1.0 Octaprenyl-diphosphate synthase 391473 ChemSpider 962 PubChem-compound C5H9O8P2 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate 258.97726 358-71-4 CAS 5800 ChemSpider CO2 Carbon dioxide 43.98983 1.0 di-trans,octa-cis-undecaprenyl diphosphate SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O ReactionCatalysis3668 ACTIVATION CMP BioCyc C00080 KEGG Compound ReactionCatalysis3669 ACTIVATION ReactionCatalysis3666 ACTIVATION ReactionCatalysis3667 ACTIVATION 729 PubChem-compound Secondary Metabolites: Ubiquinol Biosynthesis SubPathway ReactionCatalysis3664 ACTIVATION HMDB0002111 HMDB ReactionCatalysis3665 ACTIVATION CHEBI:17677 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] 6176 PubChem-compound 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2-C-methyl-D-erythritol 4-phosphate Q46822 UniProt Geranyltranstransferase CHEBI:16584 ChEBI 1-deoxy-D-xylulose-5-phosphate synthase 1.0 190079-18-6 CAS 280 PubChem-compound ReactionCatalysis3671 ACTIVATION ReactionCatalysis3672 ACTIVATION ReactionCatalysis3670 ACTIVATION ReactionCatalysis3675 ACTIVATION ReactionCatalysis3676 ACTIVATION ReactionCatalysis3673 ACTIVATION 1.0 ReactionCatalysis3674 ACTIVATION P62617 UniProt 1.0 P62615 UniProt 644102 PubChem-compound 1195 PubChem-compound 5941 ChemSpider CHEBI:17407 ChEBI Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) SMILES CC(=C)CCO[P@](O)(=O)OP(O)(O)=O C5H13O7P 2-C-methyl-D-erythritol 4-phosphate 216.03989 SMILES OC(COP(O)(O)=O)C=O 22833512 PubChem-compound H2O Water 18.010565 SMILES CC(C)=CCC\C(C)=C\CO[P@@](=O)(O)OP(=O)(O)O 1.0 1.0 HMDB0001285 HMDB 1.0 GAP BioCyc HMDB0059597 HMDB 2.0 P62623 UniProt C00661 KEGG Compound Carbon dioxide P62620 UniProt C55H92O7P2 di-trans,octa-cis-undecaprenyl diphosphate 926.63184 HMDB0001967 HMDB 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 627 ChemSpider SMILES CC(C)=CCO[P@](O)(=O)OP(O)(O)=O 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase C11437 KEGG Compound PW000906 PathWhiz 1-deoxy-D-xylulose 5-phosphate reductoisomerase HMDB0000082 HMDB 2.0 OCTAPRENYL-DIPHOSPHATE BioCyc