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Bifunctional polymyxin resistance protein ArnA UDP-4-amino- 4-deoxy-L- arabinose-- oxoglutarate aminotransferase Bifunctional polymyxin resistance protein ArnA Undecaprenyl- phosphate 4-deoxy-4- formamido-L- arabinose transferase Undecaprenyl phosphate- alpha-4- amino-4- deoxy-L- arabinose arabinosyl transferase Uridine diphosphate glucuronic acid NAD CO 2 NADH UDP-β-L- threo- pentapyranos- 4-ulose L-Glutamic acid Oxoglutaric acid UDP-4-amino- 4-deoxy-β-L- arabinopyranose 10- Formyltetrahydrofolate UDP-4-deoxy- 4-formamido- β-L- arabinopyranose H + Tetrahydrofolate di- trans,octa- cis- undecaprenyl phosphate UDP 4-deoxy-4- formamido-α- L- arabinopyranosyl ditrans,octacis- undecaprenyl phosphate H 2 O Formic acid 4-Amino-4- deoxy-α-L- arabinopyranosyl di- trans,octa- cis- undecaprenyl phosphate (KDO)2-lipid A di- trans,octa- cis- undecaprenyl diphosphate L-Ara4N- modified KDO2-Lipid A
arnA arnB arnA arnC arnT Uridine diphosphate glucuronic acid NAD Carbon dioxide NADH UDP-β-L- threo- pentapyranos- 4-ulose L-Glutamic acid Oxoglutaric acid UDP-4-amino- 4-deoxy-β-L- arabinopyranose 10- Formyltetrahydrofolate UDP-4-deoxy- 4-formamido- β-L- arabinopyranose Hydrogen Ion Tetrahydrofolate di- trans,octa- cis- undecaprenyl phosphate UDP 4-deoxy-4- formamido-α- L- arabinopyranosyl ditrans,octacis- undecaprenyl phosphate Water Formic acid 4-Amino-4- deoxy-α-L- arabinopyranosyl di- trans,octa- cis- undecaprenyl phosphate (KDO)2-lipid A di- trans,octa- cis- undecaprenyl diphosphate L-Ara4N- modified KDO2-Lipid A