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CHEBI:16015 ChEBI 6-hydroxymethyl-7,8-dihydropterin diphosphate glycinamide ribotide transformylase 30572 ChemSpider 6022 PubChem-compound 17215925 ChemSpider dihydrofolate reductase FOLic acid synthesis 3 SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1 7057990 PubChem-compound 937 ChemSpider HMDB0012199 HMDB Tetrahydrofolate Biosynthesis SMILES O Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 10-FORMYL-THF BioCyc 1.0 HMDB0002275 HMDB C00568 KEGG Compound CHEBI:16027 ChEBI 7444-29-3 CAS HMDB0000538 HMDB DIHYDROXYPHENYLGLYCOLALDEHYDE BioCyc C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 ATP BioCyc C19H19N7O6 7,8-dihydrofolate monoglutamate 441.14078 5961 PubChem-compound SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 P04161 UniProt C00445 KEGG Compound 1.0 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc 40480038 PubChem-compound 1.0 1.0 20574-65-6 CAS 1.0 1.0 559142 ChemSpider Pyruvic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 6-hydroxymethyl-7,8-dihydropterin 53-59-8 CAS 5746 ChemSpider 1.0 21865614 ChemSpider 4-amino-4-deoxychorismate 5742 ChemSpider 1038 PubChem-compound C04376 KEGG Compound 953 ChemSpider CHEBI:16474 ChEBI 5'-Phosphoribosyl-N-formylglycinamide SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O 278 ChemSpider Adenosine monophosphate 1.0 5858 ChemSpider C7H8N5O8P2 6-hydroxymethyl-7,8-dihydropterin diphosphate 351.9848 O4P Phosphate 94.95342 NADPH 6830 PubChem-compound CHEBI:17333 ChEBI 1010 ChemSpider DIHYDRONEOPTERIN-P3 BioCyc Saccharomyces cerevisiae 1.0 HMDB0001412 HMDB CHEBI:4581 ChEBI 25244074 PubChem-compound NADP PPI BioCyc ReactionCatalysis6367 ACTIVATION C21H30N7O17P3 NADPH 745.0911 SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(O)=O)CN2)C(=O)N1 C21H29N7O17P3 NADP 744.08325 ReactionCatalysis6369 ACTIVATION ReactionCatalysis6368 ACTIVATION 1.0 1.0 NADPH BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 C05925 KEGG Compound Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 10-Formyltetrahydrofolate Dihydroneopterin triphosphate Dihydroneopterin phosphate C00234 KEGG Compound Adenosine triphosphate CHEBI:58406 ChEBI L-Glutamic acid Q03266 UniProt SMILES [O-]P([O-])([O-])=O C20H21N7O6 5,10-Methenyltetrahydrofolic acid 455.15533 HMDB0000217 HMDB 122347 PubChem-compound CHEBI:15637 ChEBI 1.0 Formic acid C00009 KEGG Compound C00921 KEGG Compound C00008 KEGG Compound mitochondrial C1-tetrahydrofolate synthase C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound HMDB0001429 HMDB HMDB0001308 HMDB CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 141-46-8 CAS 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Glycolaldehyde SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C2H4O2 Glycolaldehyde 60.02113 108735 ChemSpider 150-13-0 CAS GLN BioCyc GLT BioCyc Q12676 UniProt 53-57-6 CAS C00251 KEGG Compound 7,8-dihydrofolate monoglutamate C00013 KEGG Compound CHEBI:17001 ChEBI O7P2 Pyrophosphate 173.91193 5,10-Methenyltetrahydrofolic acid NAD(P) BioCyc 1.0 5957 PubChem-compound H Hydrogen Ion 1.007825 CHEBI:15996 ChEBI CHEBI:15636 ChEBI C00022 KEGG Compound L-Glutamine 56-65-5 CAS C00020 KEGG Compound C00025 KEGG Compound Guanosine triphosphate C00266 KEGG Compound HMDB0000243 HMDB Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 Aminodeoxychorismate synthase 1.0 GTP-cyclohydrolase I aminodeoxychorismate lyase FOLic acid synthesis ReactionCatalysis6297 ACTIVATION 1.0 P09440 UniProt CPD-8587 BioCyc P53848 UniProt C03541 KEGG Compound C04874 KEGG Compound Water AMP BioCyc mitochondrial C1-tetrahydrofolate synthase HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 7,8-dihydropteroate BioCyc 14000-31-8 CAS HMDB0001341 HMDB 1218-98-0 CAS 756 PubChem-compound SMILES OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O 644350 PubChem-compound C00044 KEGG Compound 7,8-Dihydroneopterin C10H10O6 Chorismate 226.04774 5675 ChemSpider 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001354 HMDB 1.0 1.0 CHEBI:17071 ChEBI HMDB0000148 HMDB 18971002 PubChem-compound C14H14N6O3 7,8-Dihydropteroic acid 314.11273 1.0 11542 ChemSpider HMDB0000142 HMDB 7,8-Dihydropteroic acid CHEBI:15422 ChEBI 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY BioCyc CHEBI:18372 ChEBI 7732-18-5 CAS 1.0 C00058 KEGG Compound C04895 KEGG Compound Chorismate 1.0 61-19-8 CAS 6.3.2.12 false 6.3.2.12 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 617-12-9 CAS 1.5.1.3 false 1.5.1.3 7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolate LEFT_TO_RIGHT CH2O2 Formic acid 46.005478 2.1.2.2 false 2.1.2.2 10-Formyltetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate LEFT_TO_RIGHT 127-17-3 CAS 56-86-0 CAS Reaction6440 false Dihydroneopterin triphosphate + Water → Dihydroneopterin phosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT FORMATE BioCyc Reaction6441 false Dihydroneopterin phosphate + Water → 7,8-Dihydroneopterin + Phosphate LEFT_TO_RIGHT CHEBI:48954 ChEBI 4.1.2.25,2.7.6.3, 2.5.1.15 false 4.1.2.25,2.7.6.3, 2.5.1.15 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde LEFT_TO_RIGHT Reaction6443 false 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → 6-hydroxymethyl-7,8-dihydropterin diphosphate + Adenosine monophosphate + Hydrogen Ion LEFT_TO_RIGHT Reaction6444 false 6-hydroxymethyl-7,8-dihydropterin diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate LEFT_TO_RIGHT P37254 UniProt 4.1.3.38 false 4.1.3.38 4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid LEFT_TO_RIGHT 2.6.1.85 false 2.6.1.85 Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 SMILES NC1=NC2=C(N=C(CO)CN2)C(=O)N1 33032 PubChem-compound C9H16N5O13P3 Dihydroneopterin triphosphate 494.99576 SMILES [H][C@@]1(N)C=CC(=C[C@@]1([H])OC(=C)C([O-])=O)C(O)=O C10H16N5O13P3 Adenosine triphosphate 506.99576 659 PubChem-compound C20H23N7O7 10-Formyltetrahydrofolate 473.1659 349-34-8 CAS C9H14N5O7P Dihydroneopterin phosphate 335.06308 SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O C00064 KEGG Compound 2800-34-2 CAS CHEBI:16761 ChEBI p-Aminobenzoic acid C19H23N7O6 Tetrahydrofolate 445.171 HMDB0000045 HMDB SMILES CC(=O)C(O)=O 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → Dihydroneopterin triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT C7H7NO2 p-Aminobenzoic acid 137.04768 P-AMINO-BENZOATE BioCyc 121885 PubChem-compound Tetrahydrofolate 1.0 HMDB0006824 HMDB SMP0002334 SMPDB 115687 ChemSpider 962 PubChem-compound ReactionCatalysis6370 ACTIVATION CPD-9517 BioCyc ReactionCatalysis6374 ACTIVATION ReactionCatalysis6373 ACTIVATION ReactionCatalysis6372 ACTIVATION ReactionCatalysis6371 ACTIVATION 5800 ChemSpider 130805 PubChem-compound 736 ChemSpider Phosphate 1.0 C00080 KEGG Compound CHEBI:30753 ChEBI HMDB0000972 HMDB CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 170 PubChem-compound 1.0 ReactionCatalysis6375 ACTIVATION HMDB0002111 HMDB CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O 1.0 SMILES OC=O CHEBI:15377 ChEBI C10H10NO5 4-amino-4-deoxychorismate 224.05644 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS 5,10-methenyl-thf BioCyc C7H9N5O2 6-hydroxymethyl-7,8-dihydropterin 195.07562 PYRUVATE BioCyc 6569 ChemSpider 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound SMILES NC1=NC2=C(N=C(CN2)[C@H](O)[C@H](O)COP(O)(O)=O)C(=O)N1 GTP BioCyc FOLic acid synthesis 3 dihydrofolate reductase SMILES NC1=NC2=C(N=C(CN2)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(=O)N1 glycinamide ribotide transformylase HMDB0000980 HMDB SMILES NC1=CC=C(C=C1)C(O)=O 1.0 1.0 24771767 PubChem-compound 165 ChemSpider HMDB0001392 HMDB HMDB0001273 HMDB 644102 PubChem-compound 4932 TAXONOMY GTP-cyclohydrolase I FOLic acid synthesis 6083 PubChem-compound aminodeoxychorismate lyase Reaction6371 false 5,10-Methenyltetrahydrofolic acid + Water → 10-Formyltetrahydrofolate + Hydrogen Ion LEFT_TO_RIGHT Aminodeoxychorismate synthase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 639 ChemSpider 64-18-6 CAS SMILES N[C@@H](CCC(N)=O)C(O)=O C9H13N5O4 7,8-Dihydroneopterin 255.09676 2134-76-1 CAS SMILES [H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O 22833512 PubChem-compound 1.0 CHEBI:18050 ChEBI H2O Water 18.010565 CHEBI:17083 ChEBI P51601 UniProt P07807 UniProt PW002417 PathWhiz 86-01-1 CAS HMDB0003344 HMDB 1060 PubChem-compound 1061 PubChem-compound HMDB0059597 HMDB 109092 ChemSpider 559356 ChemSpider 12039 PubChem-compound SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(NCC2=NC3=C(NC2)NC(=N)N=C3[O-])C=C1)C(O)=O HMDB0000641 HMDB SMILES OCC=O 1.0 GTP- cyclohydrolase I FOLic acid synthesis FOLic acid synthesis FOLic acid synthesis aminodeoxychorismate lyase Aminodeoxychorismate synthase FOLic acid synthesis 3 dihydrofolate reductase glycinamide ribotide transformylase mitochondrial C1- tetrahydrofolate synthase Guanosine triphosphate H 2 O Formic acid H + Dihydroneopterin triphosphate H 2 O Dihydroneopterin phosphate PP i H + H 2 O 7,8- Dihydroneopterin P i Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin ATP AMP H + 6- hydroxymethyl- 7,8- dihydropterin diphosphate p-Aminobenzoic acid PP i 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate H + Pyruvic acid Chorismate L-Glutamine L-Glutamic acid ATP L-Glutamic acid ADP P i H + 7,8- dihydrofolate monoglutamate H + NADPH NADP Tetrahydrofolate 10- Formyltetrahydrofolate 5'- Phosphoribosyl- N- formylglycinamide 5'- Phosphoribosyl- N- formylglycinamide 5,10- Methenyltetrahydrofolic acid H 2 O H +
CHEBI:16015 ChEBI 6-hydroxymethyl-7,8-dihydropterin diphosphate glycinamide ribotide transformylase 30572 ChemSpider 6022 PubChem-compound 17215925 ChemSpider dihydrofolate reductase FOLic acid synthesis 3 SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1 7057990 PubChem-compound 937 ChemSpider HMDB0012199 HMDB Tetrahydrofolate Biosynthesis SMILES O Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 10-FORMYL-THF BioCyc 1.0 HMDB0002275 HMDB C00568 KEGG Compound CHEBI:16027 ChEBI 7444-29-3 CAS HMDB0000538 HMDB DIHYDROXYPHENYLGLYCOLALDEHYDE BioCyc C8H15N2O9P 5'-Phosphoribosyl-N-formylglycinamide 314.0515 ATP BioCyc C19H19N7O6 7,8-dihydrofolate monoglutamate 441.14078 5961 PubChem-compound SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 P04161 UniProt C00445 KEGG Compound 1.0 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE BioCyc 40480038 PubChem-compound 1.0 1.0 20574-65-6 CAS 1.0 1.0 559142 ChemSpider Pyruvic acid ADP BioCyc C3H4O3 Pyruvic acid 88.016045 6-hydroxymethyl-7,8-dihydropterin 53-59-8 CAS 5746 ChemSpider 1.0 21865614 ChemSpider 4-amino-4-deoxychorismate 5742 ChemSpider 1038 PubChem-compound C04376 KEGG Compound 953 ChemSpider CHEBI:16474 ChEBI 5'-Phosphoribosyl-N-formylglycinamide SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O 278 ChemSpider Adenosine monophosphate 1.0 5858 ChemSpider C7H8N5O8P2 6-hydroxymethyl-7,8-dihydropterin diphosphate 351.9848 O4P Phosphate 94.95342 NADPH 6830 PubChem-compound CHEBI:17333 ChEBI 1010 ChemSpider DIHYDRONEOPTERIN-P3 BioCyc Saccharomyces cerevisiae 1.0 HMDB0001412 HMDB CHEBI:4581 ChEBI 25244074 PubChem-compound NADP PPI BioCyc ReactionCatalysis6367 ACTIVATION C21H30N7O17P3 NADPH 745.0911 SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(O)=O)CN2)C(=O)N1 C21H29N7O17P3 NADP 744.08325 ReactionCatalysis6369 ACTIVATION ReactionCatalysis6368 ACTIVATION 1.0 1.0 NADPH BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 C05925 KEGG Compound Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 10-Formyltetrahydrofolate Dihydroneopterin triphosphate Dihydroneopterin phosphate C00234 KEGG Compound Adenosine triphosphate CHEBI:58406 ChEBI L-Glutamic acid Q03266 UniProt SMILES [O-]P([O-])([O-])=O C20H21N7O6 5,10-Methenyltetrahydrofolic acid 455.15533 HMDB0000217 HMDB 122347 PubChem-compound CHEBI:15637 ChEBI 1.0 Formic acid C00009 KEGG Compound C00921 KEGG Compound C00008 KEGG Compound mitochondrial C1-tetrahydrofolate synthase C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound HMDB0001429 HMDB HMDB0001308 HMDB CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 141-46-8 CAS 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Glycolaldehyde SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C2H4O2 Glycolaldehyde 60.02113 108735 ChemSpider 150-13-0 CAS GLN BioCyc GLT BioCyc Q12676 UniProt 53-57-6 CAS C00251 KEGG Compound 7,8-dihydrofolate monoglutamate C00013 KEGG Compound CHEBI:17001 ChEBI O7P2 Pyrophosphate 173.91193 5,10-Methenyltetrahydrofolic acid NAD(P) BioCyc 1.0 5957 PubChem-compound H Hydrogen Ion 1.007825 CHEBI:15996 ChEBI CHEBI:15636 ChEBI C00022 KEGG Compound L-Glutamine 56-65-5 CAS C00020 KEGG Compound C00025 KEGG Compound Guanosine triphosphate C00266 KEGG Compound HMDB0000243 HMDB Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 Aminodeoxychorismate synthase 1.0 GTP-cyclohydrolase I aminodeoxychorismate lyase FOLic acid synthesis ReactionCatalysis6297 ACTIVATION 1.0 P09440 UniProt CPD-8587 BioCyc P53848 UniProt C03541 KEGG Compound C04874 KEGG Compound Water AMP BioCyc mitochondrial C1-tetrahydrofolate synthase HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 7,8-dihydropteroate BioCyc 14000-31-8 CAS HMDB0001341 HMDB 1218-98-0 CAS 756 PubChem-compound SMILES OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O 644350 PubChem-compound C00044 KEGG Compound 7,8-Dihydroneopterin C10H10O6 Chorismate 226.04774 5675 ChemSpider 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001354 HMDB 1.0 1.0 CHEBI:17071 ChEBI HMDB0000148 HMDB 18971002 PubChem-compound C14H14N6O3 7,8-Dihydropteroic acid 314.11273 1.0 11542 ChemSpider HMDB0000142 HMDB 7,8-Dihydropteroic acid CHEBI:15422 ChEBI 6-1S2R-12-DIHYDROXY-3-TRIPHOSPHOOXY BioCyc CHEBI:18372 ChEBI 7732-18-5 CAS 1.0 C00058 KEGG Compound C04895 KEGG Compound Chorismate 1.0 61-19-8 CAS 6.3.2.12 false 6.3.2.12 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 617-12-9 CAS 1.5.1.3 false 1.5.1.3 7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolate LEFT_TO_RIGHT CH2O2 Formic acid 46.005478 2.1.2.2 false 2.1.2.2 10-Formyltetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate LEFT_TO_RIGHT 127-17-3 CAS 56-86-0 CAS Reaction6440 false Dihydroneopterin triphosphate + Water → Dihydroneopterin phosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT FORMATE BioCyc Reaction6441 false Dihydroneopterin phosphate + Water → 7,8-Dihydroneopterin + Phosphate LEFT_TO_RIGHT CHEBI:48954 ChEBI 4.1.2.25,2.7.6.3, 2.5.1.15 false 4.1.2.25,2.7.6.3, 2.5.1.15 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde LEFT_TO_RIGHT Reaction6443 false 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → 6-hydroxymethyl-7,8-dihydropterin diphosphate + Adenosine monophosphate + Hydrogen Ion LEFT_TO_RIGHT Reaction6444 false 6-hydroxymethyl-7,8-dihydropterin diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate LEFT_TO_RIGHT P37254 UniProt 4.1.3.38 false 4.1.3.38 4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid LEFT_TO_RIGHT 2.6.1.85 false 2.6.1.85 Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 SMILES NC1=NC2=C(N=C(CO)CN2)C(=O)N1 33032 PubChem-compound C9H16N5O13P3 Dihydroneopterin triphosphate 494.99576 SMILES [H][C@@]1(N)C=CC(=C[C@@]1([H])OC(=C)C([O-])=O)C(O)=O C10H16N5O13P3 Adenosine triphosphate 506.99576 659 PubChem-compound C20H23N7O7 10-Formyltetrahydrofolate 473.1659 349-34-8 CAS C9H14N5O7P Dihydroneopterin phosphate 335.06308 SMILES O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O C00064 KEGG Compound 2800-34-2 CAS CHEBI:16761 ChEBI p-Aminobenzoic acid C19H23N7O6 Tetrahydrofolate 445.171 HMDB0000045 HMDB SMILES CC(=O)C(O)=O 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → Dihydroneopterin triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT C7H7NO2 p-Aminobenzoic acid 137.04768 P-AMINO-BENZOATE BioCyc 121885 PubChem-compound Tetrahydrofolate 1.0 HMDB0006824 HMDB SMP0002334 SMPDB 115687 ChemSpider 962 PubChem-compound ReactionCatalysis6370 ACTIVATION CPD-9517 BioCyc ReactionCatalysis6374 ACTIVATION ReactionCatalysis6373 ACTIVATION ReactionCatalysis6372 ACTIVATION ReactionCatalysis6371 ACTIVATION 5800 ChemSpider 130805 PubChem-compound 736 ChemSpider Phosphate 1.0 C00080 KEGG Compound CHEBI:30753 ChEBI HMDB0000972 HMDB CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 170 PubChem-compound 1.0 ReactionCatalysis6375 ACTIVATION HMDB0002111 HMDB CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O 1.0 SMILES OC=O CHEBI:15377 ChEBI C10H10NO5 4-amino-4-deoxychorismate 224.05644 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS 5,10-methenyl-thf BioCyc C7H9N5O2 6-hydroxymethyl-7,8-dihydropterin 195.07562 PYRUVATE BioCyc 6569 ChemSpider 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound SMILES NC1=NC2=C(N=C(CN2)[C@H](O)[C@H](O)COP(O)(O)=O)C(=O)N1 GTP BioCyc FOLic acid synthesis 3 dihydrofolate reductase SMILES NC1=NC2=C(N=C(CN2)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(=O)N1 glycinamide ribotide transformylase HMDB0000980 HMDB SMILES NC1=CC=C(C=C1)C(O)=O 1.0 1.0 24771767 PubChem-compound 165 ChemSpider HMDB0001392 HMDB HMDB0001273 HMDB 644102 PubChem-compound 4932 TAXONOMY GTP-cyclohydrolase I FOLic acid synthesis 6083 PubChem-compound aminodeoxychorismate lyase Reaction6371 false 5,10-Methenyltetrahydrofolic acid + Water → 10-Formyltetrahydrofolate + Hydrogen Ion LEFT_TO_RIGHT Aminodeoxychorismate synthase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 639 ChemSpider 64-18-6 CAS SMILES N[C@@H](CCC(N)=O)C(O)=O C9H13N5O4 7,8-Dihydroneopterin 255.09676 2134-76-1 CAS SMILES [H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O 22833512 PubChem-compound 1.0 CHEBI:18050 ChEBI H2O Water 18.010565 CHEBI:17083 ChEBI P51601 UniProt P07807 UniProt PW002417 PathWhiz 86-01-1 CAS HMDB0003344 HMDB 1060 PubChem-compound 1061 PubChem-compound HMDB0059597 HMDB 109092 ChemSpider 559356 ChemSpider 12039 PubChem-compound SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(NCC2=NC3=C(NC2)NC(=N)N=C3[O-])C=C1)C(O)=O HMDB0000641 HMDB SMILES OCC=O 1.0