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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 278165 results

SMP0121011

Pw122278 View Pathway
Metabolite

Kidney Function - Collecting Duct

Homo sapiens

  • Matched Description: release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary … circulation at the collecting duct via potassium and sodium channels. However, aldosterone is a major … The collecting duct of the nephron is the last segment of the functioning nephron and is connected … to minor calyces and the ensuing renal pelvis of the kidney where urine continues before it is … stored in the bladder. The collecting duct is mainly responsible for the excretion and reabsorption of
  • Matched Compounds: Aldosterone
  • Matched Compound Synonyms: [co2(oh)](-) … (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Physiological

    SMP0126084

    Pw127662 View Pathway
    Metabolite

    Acemetacin Action Pathway

    Homo sapiens

  • Matched Description: Acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a … approved. It has analgesic, antipyretic, and anti-inflammatory effects. It targets the prostaglandin G … /H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The … inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to
  • Matched Compound Synonyms: Fa(20:4(5z,8z,11z,14z)) … for oral administration. acemetacin mode of action as an anti-inflammatory and antirheumatic agent may … be due to inhibition of synthesis and release of prostaglandins. the usefulness of indometacin, the … . acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … , n-desacylation and part of them are also transformed by conjugation with glucuronic acid. the

  • Drug Action

    SMP0123090

    Pw124435 View Pathway
    Metabolite

    Fosinopril ACE Inhibitor Action Pathway

    Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Fosinopril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0122803

    Pw124137 View Pathway
    Metabolite

    Benazepril ACE inhibitor Action Pathway

    Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Benazepril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0124967

    Pw126474 View Pathway
    Metabolite

    Irbesartan Angiotensin blocker Action Pathway

    Homo sapiens

  • Matched Description: the kidney are responsible for the production of aldosterone which increases salt and water retention … that has powerful vasoconstrictive effects and increases blood pressure. Irbesartan is used to treat … hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure … vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels AT1 receptors cause … which increases blood volume. Blocking AT1 receptors reduces aldosterone production allowing water
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0126074

    Pw127650 View Pathway
    Metabolite

    Zofenopril Action Pathway

    Homo sapiens

  • Matched Description: of acute myocardial infaction (AMI), hypertension and mild to mmoderate hypertension. Zafenopril … has the ability to improve endothelial function and protect against ischemia. Zofenopril is a prodrug … and this leads to an increase of blood pressure. This system starts with the renin being released from … . Angiotensin II binds to AT1 and AT2, these receptors will activate many signaling cascades that … will lead to the retaining of sodium and water in the renal tubules. At the same time, these receptors
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0120768

    Pw122029 View Pathway
    Metabolite

    Lysinuric Protein Intolerance

    Rattus norvegicus

  • Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Disease

    SMP0123094

    Pw124439 View Pathway
    Metabolite

    Quinapril ACE Inhibitor Action Pathway

    Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Quinapril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors in
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0124966

    Pw126473 View Pathway
    Metabolite

    Forasartan Angiotensin Blocker Action Pathway

    Homo sapiens

  • Matched Description: and water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone … that has powerful vasoconstrictive effects and increases blood pressure. Forasartan used to treat … receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels AT1 … . AT1 receptors in the kidney are responsible for the production of aldosterone which increases salt
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0126015

    Pw127589 View Pathway
    Metabolite

    Saprisartan Action Pathway

    Homo sapiens

  • Matched Description: II. By inhibiting those actions, saprosartan leads to a decrease in sodium reabsorpion and a decrease
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action