SMP0119376
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Kidney Function
Bos taurus
Matched Description: angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an … , nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid … volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium … , chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending … loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2 … Solute carrier family 3 (Cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0120546
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Hartnup Disorder
Mus musculus
Matched Description: -isoleucine, L-leucine, L-phenylalanine, L-serine, L-threonine, L-tryptophan, L-valine, and L-tyrosine in … urine. Symptoms include pellagra, psychosis, ataxia, and mental retardation. Treatment includes nicotinamide.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0121011
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Kidney Function - Collecting Duct
Homo sapiens
Matched Description: release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary … circulation at the collecting duct via potassium and sodium channels. However, aldosterone is a major … The collecting duct of the nephron is the last segment of the functioning nephron and is connected … to minor calyces and the ensuing renal pelvis of the kidney where urine continues before it is … stored in the bladder. The collecting duct is mainly responsible for the excretion and reabsorption of
Matched Compounds: Aldosterone
Matched Compound Synonyms: [co2(oh)](-) … (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0120767
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Iminoglycinuria
Rattus norvegicus
Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0120548
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Lysinuric Protein Intolerance
Mus musculus
Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000086
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Ibuprofen Action Pathway
Homo sapiens
Matched Description: Ibuprofen is a very common NSAID drug used to treat pain and inflammation. This includes headaches … , muscle pain and fever. It is sold under the brand name Advil or Motrin. Ibuprofen is typically … prostaglandin G/H synthase (COX). These enzymes are available as COX1 and COX2, and are encoded by … PTGS1 (COX1) and PTGS2 (COX2). Ibuprofen may also inhibit fatty acid amide hydrolase (FAAH), which
Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))
Matched Protein Synonyms: Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20
Matched Compound Synonyms: 20-oh-leukotriene b4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-ltb4 … 20-carboxy-leukotriene b4
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SMP0123094
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Quinapril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Quinapril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors in
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0124966
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Forasartan Angiotensin Blocker Action Pathway
Homo sapiens
Matched Description: and water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone … that has powerful vasoconstrictive effects and increases blood pressure. Forasartan used to treat … receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary.
In blood vessels AT1 … . AT1 receptors in the kidney are responsible for the production of aldosterone which increases salt
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0126015
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Saprisartan Action Pathway
Homo sapiens
Matched Description: II. By inhibiting those actions, saprosartan leads to a decrease in sodium reabsorpion and a decrease
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0123095
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Ramipril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Ramipril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors in
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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