SMP0121011
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Kidney Function - Collecting Duct
Homo sapiens
Matched Description: release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary … circulation at the collecting duct via potassium and sodium channels. However, aldosterone is a major … The collecting duct of the nephron is the last segment of the functioning nephron and is connected … to minor calyces and the ensuing renal pelvis of the kidney where urine continues before it is … stored in the bladder. The collecting duct is mainly responsible for the excretion and reabsorption of
Matched Compounds: Aldosterone
Matched Compound Synonyms: [co2(oh)](-) … (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0126084
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Acemetacin Action Pathway
Homo sapiens
Matched Description: Acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a … approved. It has analgesic, antipyretic, and anti-inflammatory effects. It targets the prostaglandin G … /H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The … inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to
Matched Compound Synonyms: Fa(20:4(5z,8z,11z,14z)) … for oral administration. acemetacin mode of action as an anti-inflammatory and antirheumatic agent may … be due to inhibition of synthesis and release of prostaglandins. the usefulness of indometacin, the … . acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … , n-desacylation and part of them are also transformed by conjugation with glucuronic acid. the
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SMP0123090
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Fosinopril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Fosinopril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0122803
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Benazepril ACE inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Benazepril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0124967
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Irbesartan Angiotensin blocker Action Pathway
Homo sapiens
Matched Description: the kidney are responsible for the production of aldosterone which increases salt and water retention … that has powerful vasoconstrictive effects and increases blood pressure. Irbesartan is used to treat … hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure … vessels, kidneys, hypothalamus, and posterior pituitary.
In blood vessels AT1 receptors cause … which increases blood volume. Blocking AT1 receptors reduces aldosterone production allowing water
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0126074
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Zofenopril Action Pathway
Homo sapiens
Matched Description: of acute myocardial infaction (AMI), hypertension and mild to mmoderate hypertension. Zafenopril … has the ability to improve endothelial function and protect against ischemia. Zofenopril is a prodrug … and this leads to an increase of blood pressure. This system starts with the renin being released from … . Angiotensin II binds to AT1 and AT2, these receptors will activate many signaling cascades that … will lead to the retaining of sodium and water in the renal tubules. At the same time, these receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0120768
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Lysinuric Protein Intolerance
Rattus norvegicus
Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0123094
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Quinapril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Quinapril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors in
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0124966
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Forasartan Angiotensin Blocker Action Pathway
Homo sapiens
Matched Description: and water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone … that has powerful vasoconstrictive effects and increases blood pressure. Forasartan used to treat … receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary.
In blood vessels AT1 … . AT1 receptors in the kidney are responsible for the production of aldosterone which increases salt
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0126015
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Saprisartan Action Pathway
Homo sapiens
Matched Description: II. By inhibiting those actions, saprosartan leads to a decrease in sodium reabsorpion and a decrease
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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