SMP0120647
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Blue Diaper Syndrome
Mus musculus
Matched Description: symptoms can include bacterial infections, damage to various parts of the eye, hypercalcemia, and impaired … hypercalcemia, and a tryptophan restricted diet to prevent all systems. If bacterial infections are common, antibiotics may be prescribed.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0122731
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Eplerenone Action Pathway
Homo sapiens
Matched Description: occurs via the aquaporins.
Aldosterone is released from the adrenal cortex of the kidney and acts on the … and blocks aldosterone binding. This prevents the aldosterone effects on gene transcription … Eplerenone is an oral drug used to treat conditions such as hypertension and congestive heart … duct, sodium and water reabsorption occur, along with potassium excretion. The sodium channel (ENaC … the lumen where it is excreted in urine. Water reabsorption is linked to Na+ reabsorption and
Matched Compounds: Aldosterone
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone
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SMP0121011
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Kidney Function - Collecting Duct
Homo sapiens
Matched Description: release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary … circulation at the collecting duct via potassium and sodium channels. However, aldosterone is a major … The collecting duct of the nephron is the last segment of the functioning nephron and is connected … to minor calyces and the ensuing renal pelvis of the kidney where urine continues before it is … stored in the bladder. The collecting duct is mainly responsible for the excretion and reabsorption of
Matched Compounds: Aldosterone
Matched Compound Synonyms: [co2(oh)](-) … (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0123092
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Moexipril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Moexipril is used to treat hypertension, high … blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0123104
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Trandolapril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: for the production of aldosterone which increases salt and water retention which increases blood … vasoconstrictive effects and increases blood pressure. Trandolapril is used to treat hypertension … , high blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … by binding to angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and … volume. Less angiotensin II reduces aldosterone production allowing water retention to not increase
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0124964
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Candesartan Action Pathway (New)
Homo sapiens
Matched Description: aldosterone which increases salt and water retention which increases blood volume. Blocking AT1 … that has powerful vasoconstrictive effects and increases blood pressure. Candesartan is used to treat … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … receptors reduces aldosterone production allowing water retention to not increase. AT1 receptors in the … effects of taking candesartan are symptomatic hypotension, abnormal renal function, and
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0124969
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Telmisartan Action Pathway (New)
Homo sapiens
Matched Description: for the production of aldosterone which increases salt and water retention which increases blood … that has powerful vasoconstrictive effects and increases blood pressure. Telmisartan used to treat … hypertension, diabetic nephropathy, and congestive heart failure. Angiotensin has many … , hypothalamus, and posterior pituitary.
In blood vessels AT1 receptors cause vasoconstriction in the tunica … volume. Blocking AT1 receptors reduces aldosterone production allowing water retention to not increase
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0126013
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Tasosartan Action Pathway
Homo sapiens
Matched Description: , reduced secretion of avsopressin (ADH), and reduced production and secretion of aldosterone. … the treatment of hypertension and heart failure. This drug causes the blockade of the renin … -angiotensin-aldosterone system (RAAS) at the level of the AT1 receptor. Tasosartan is an antagonist of the AT1 … receptors localize in the vascular muscles and the adrenal gland. This drug thus causes dilatation
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0122986
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Cilazapril ACE inhibitor Action Pathway
Homo sapiens
Matched Description: well, reducing aldosterone and vasopressin secretion, inhibiting vasoconstriction, and allowing the … uptake of sodium and insufficient potassium excretion due to reduced aldosterone levels. Cilazapril is eliminated by the kidneys and excreted through urination. … treat hypertension and heart failure as it reduces the effects of angiotensin II which decreases … resistance and blood pressure, as angiotensin II is a potent vasoconstrictor. Angiotensin II is produced … the kidneys, blood vessels, posterior pituitary gland and excitatory amino acid transporter via
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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SMP0124966
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Forasartan Angiotensin Blocker Action Pathway
Homo sapiens
Matched Description: and water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone … that has powerful vasoconstrictive effects and increases blood pressure. Forasartan used to treat … receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary.
In blood vessels AT1 … . AT1 receptors in the kidney are responsible for the production of aldosterone which increases salt
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
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