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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 517638 results

SMP0119387

Pw120610 View Pathway
Metabolite

Kidney Function

Rattus norvegicus

  • Matched Description: angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an … , nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid … volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium … , chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending … loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of

  • Matched Compounds: Aldosterone

  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Physiological

    SMP0000695

    Pw000672 View Pathway
    Metabolite

    Etoricoxib Action Pathway

    Homo sapiens

  • Matched Description: , pain, swelling, inflammation, and platelet aggregation. Etoricoxib can block prostaglandin synthesis … by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and … 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000700

    Pw000677 View Pathway
    Metabolite

    Lornoxicam Action Pathway

    Homo sapiens

  • Matched Description: be used to treat moderate pain such as pain relieving. It can also treat swelling and fever reducing … synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2 … , and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Decreased

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000707

    Pw000684 View Pathway
    Metabolite

    Salsalate Action Pathway

    Homo sapiens

  • Matched Description: (NSAID). It can be used to treat pain, fever and inflammation. Salsalate can block prostaglandin … synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 … and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000098

    Pw000139 View Pathway
    Metabolite

    Ketorolac Action Pathway

    Homo sapiens

  • Matched Description: relieve pain (analgesic), reduce fever (antipyretic) and swelling. Ketorolac can block prostaglandin … synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H … synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 … process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000102

    Pw000259 View Pathway
    Metabolite

    Bromfenac Action Pathway

    Homo sapiens

  • Matched Description: ). It can be used to reduce ocular inflammation and pain after cataract surgery. Bromfenac is also a … action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 … catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000109

    Pw000261 View Pathway
    Metabolite

    Mefenamic Acid Action Pathway

    Homo sapiens

  • Matched Description: used to relieve pain (analgesic) and reduce fever (antipyretic). Mefenamic acid can block prostaglandin … synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H … synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 … process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0122731

    Pw124055 View Pathway
    Metabolite

    Eplerenone Action Pathway

    Homo sapiens

  • Matched Description: occurs via the aquaporins. Aldosterone is released from the adrenal cortex of the kidney and acts on the … and blocks aldosterone binding. This prevents the aldosterone effects on gene transcription … Eplerenone is an oral drug used to treat conditions such as hypertension and congestive heart … duct, sodium and water reabsorption occur, along with potassium excretion. The sodium channel (ENaC … the lumen where it is excreted in urine. Water reabsorption is linked to Na+ reabsorption and

  • Matched Compounds: Aldosterone

  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0121011

    Pw122278 View Pathway
    Metabolite

    Kidney Function - Collecting Duct

    Homo sapiens

  • Matched Description: release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary … circulation at the collecting duct via potassium and sodium channels. However, aldosterone is a major … The collecting duct of the nephron is the last segment of the functioning nephron and is connected … to minor calyces and the ensuing renal pelvis of the kidney where urine continues before it is … stored in the bladder. The collecting duct is mainly responsible for the excretion and reabsorption of

  • Matched Compounds: Aldosterone

  • Matched Compound Synonyms: [co2(oh)](-) … (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Physiological

    SMP0000692

    Pw000669 View Pathway
    Metabolite

    Antipyrine Action Pathway

    Homo sapiens

  • Matched Description: of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze … the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action