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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 200275 results

SMP0123093

Pw124438 View Pathway
Metabolite

Perindopril ACE Inhibitor Action Pathway

Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume … vasoconstrictive effects and increases blood pressure. Perindopril is used to treat hypertension, high … blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … binding to angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior … . Less angiotensin II reduces aldosterone production allowing water retention to not increase. AT1

  • Matched Compounds: Aldosterone

  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0124970

    Pw126477 View Pathway
    Metabolite

    Valsartan Action Pathway (New)

    Homo sapiens

  • Matched Description: responsible for the production of aldosterone which increases salt and water retention which … that has powerful vasoconstrictive effects and increases blood pressure. Valsartan is indicated for the … treatment of hypertension to reduce the risk of fatal and nonfatal cardiovascular events, primarily … strokes and myocardial infarctions. It is also indicated for the treatment of heart failure (NYHA … class II-IV) and for left ventricular dysfunction or failure after myocardial infarction when the use

  • Matched Compounds: Aldosterone

  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0126016

    Pw127590 View Pathway
    Metabolite

    Candesartan cilexetil Action Pathway

    Homo sapiens

  • Matched Description: , AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II are inhibited … vasoconstrictive and aldosterone-secreting effects of angiotensin II. Candesartan cilexetil is available as a tablet. … receptors (AT1) in vascular smooth muscle and adrenal glands. In consequence of this interaction … (inhibition of the RAAS). The last inhibition may increase sodium and water excretion while decresing the … . Angiotensin II increases blood pressure by increasing sodium and water reabsorption in the kidneys

  • Matched Compounds: Aldosterone

  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0127068

    Pw128687 View Pathway
    Metabolite

    ACE

    Homo sapiens

  • Matched Description: are degradation of bradykinin, substance P, and amyloid beta-protein. Angiotensin converting enzyme … (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade … bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and … of an epidemic in 2002–2003. Two isozymes of ACE are present in mammals: somatic ACE and testis ACE … . Somatic ACE possesses two catalytic domains (N- and C-domains) and a C-terminal transmembrane

  • Matched Compounds: Aldosterone

  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Physiological

    SMP0000707

    Pw000684 View Pathway
    Metabolite

    Salsalate Action Pathway

    Homo sapiens

  • Matched Description: (NSAID). It can be used to treat pain, fever and inflammation. Salsalate can block prostaglandin … synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 … and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000695

    Pw000672 View Pathway
    Metabolite

    Etoricoxib Action Pathway

    Homo sapiens

  • Matched Description: , pain, swelling, inflammation, and platelet aggregation. Etoricoxib can block prostaglandin synthesis … by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and … 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000109

    Pw000261 View Pathway
    Metabolite

    Mefenamic Acid Action Pathway

    Homo sapiens

  • Matched Description: used to relieve pain (analgesic) and reduce fever (antipyretic). Mefenamic acid can block prostaglandin … synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H … synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 … process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000098

    Pw000139 View Pathway
    Metabolite

    Ketorolac Action Pathway

    Homo sapiens

  • Matched Description: relieve pain (analgesic), reduce fever (antipyretic) and swelling. Ketorolac can block prostaglandin … synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H … synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 … process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000700

    Pw000677 View Pathway
    Metabolite

    Lornoxicam Action Pathway

    Homo sapiens

  • Matched Description: be used to treat moderate pain such as pain relieving. It can also treat swelling and fever reducing … synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2 … , and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Decreased

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000102

    Pw000259 View Pathway
    Metabolite

    Bromfenac Action Pathway

    Homo sapiens

  • Matched Description: ). It can be used to reduce ocular inflammation and pain after cataract surgery. Bromfenac is also a … action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 … catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action