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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 281790 results

SMP0127071 View Pathway	Metabolite ACE Rattus norvegicus Matched Description: are degradation of bradykinin, substance P, and amyloid beta-protein. Angiotensin converting enzyme … (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade … bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and … of an epidemic in 2002–2003. Two isozymes of ACE are present in mammals: somatic ACE and testis ACE … . Somatic ACE possesses two catalytic domains (N- and C-domains) and a C-terminal transmembrane Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Physiological
SMP0000160 View Pathway	Metabolite Forasartan Action Pathway Homo sapiens Matched Description: the effects of aldosterone on electrolyte and water excretion, refer to the description of the … .) to prevent increasing sodium, water reabsorption and peripheral resistance (that will lead to … increasing blood pressure) via aldosterone secretion that is caused by angiotensin II. Therefore … /pathways/SMP00132/pathway pathway, which describes the mechanism of direct aldosterone antagonists … . Candesartan is an effective agent for reducing blood pressure and may be used to treat essential hypertension and heart failure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000150 View Pathway	Metabolite Lisinopril Action Pathway Homo sapiens Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and … increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000152 View Pathway	Metabolite Perindopril Action Pathway Homo sapiens Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and … increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000165 View Pathway	Metabolite Valsartan Action Pathway Homo sapiens Matched Description: blood pressure. For more information on the effects of aldosterone on electrolyte and water … . vascular smooth muscle, the adrenal glands, etc.) to prevent increasing sodium, water reabsorption and … peripheral resistance (that will lead to increasing blood pressure) via aldosterone secretion that … mechanism of direct aldosterone antagonists. Valsartan is an effective agent for reducing blood … pressure and may be used to treat essential hypertension and heart failure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000158 View Pathway	Metabolite Candesartan Action Pathway Homo sapiens Matched Description: the effects of aldosterone on electrolyte and water excretion, refer to the description of the … .) to prevent increasing sodium, water reabsorption and peripheral resistance (that will lead to … increasing blood pressure) via aldosterone secretion that is caused by angiotensin II. Therefore … spironolactone or triamterene pathways, which describes the mechanism of direct aldosterone antagonists … . Candesartan is an effective agent for reducing blood pressure and may be used to treat essential hypertension and heart failure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000145 View Pathway	Metabolite Benazepril Action Pathway Homo sapiens Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug … can also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and … increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000157 View Pathway	Metabolite Trandolapril Action Pathway Homo sapiens Matched Description: ) is a component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Trandolapril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and … increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0126525 View Pathway	Metabolite Etonogestrel Action Pathway Homo sapiens Matched Description: hypothalamus, and the pituitary. By those binding, this drug reduces the secretion of GnRH from the … increases the viscosity of the cervical mucus. This blocks the passage of spermatozoa and alters the Matched Protein Synonyms: 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD … 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD Matched Compound Synonyms: 20-iso-cholesterol … (3b)-3-hydroxy-pregn-5-en-20-one … 3-hydroxypregn-5-en-20-one … 3b-hydroxypregn-5-en-20-one … 3beta-hydroxypregn-5-en-20-one BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0126536 View Pathway	Metabolite Norethisterone Action Pathway Homo sapiens Matched Description: contraception, prevention of endometrial hyperplasia (hormone replacement therapy), and in the treatment of … greater potency. This drug acts by altering the cervical and endometrial function, as well as it … inhibits the pituitary hormones, like the Follicle-stimulating hormone (FSH) and the Luteinizing … hormone (GnRH) production in the hypothalamus. The low levels of LH and FSH result in the inhibition of … the production of estrogen in the ovaries, thus inhibiting follicular maturation, ovulation, and Matched Protein Synonyms: 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD … 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD Matched Compound Synonyms: 20-iso-cholesterol … (3b)-3-hydroxy-pregn-5-en-20-one … 3-hydroxypregn-5-en-20-one … 3b-hydroxypregn-5-en-20-one … 3beta-hydroxypregn-5-en-20-one BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action