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Matched Description: enzyme (ACE) is a component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves … angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure … (hypertension). This drug can also be used in the treatment of congestive heart failure and type II diabetes … concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I into … (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Ramipril is a prodrug … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: the release of aldosterone from the adrenal cortex and release of vasopressin from the posterior … The distal convoluted tubule of the nephron is the part of the kidney between the loop of henle and … reabsorption back into the blood circulation. In addition, sodium, chlorine, and calcium are also … reabsorbed back into the systemic circulation via their respective channels and exchangers. However … , aldosterone is a major regulator of the reabsorption of these ions as well, as it changes the

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: are degradation of bradykinin, substance P, and amyloid beta-protein. Angiotensin converting enzyme … (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade … bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and … of an epidemic in 2002–2003. Two isozymes of ACE are present in mammals: somatic ACE and testis ACE … . Somatic ACE possesses two catalytic domains (N- and C-domains) and a C-terminal transmembrane

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: causes tyrosine and phenylalanine to accumulate in the blood resulting in increased excretion of … tyrosine in the urine. Tyrosinemia type 3 symptoms include: seizures, mental retardation and intermittent ataxia (occasional loss of balance and coordination).

Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]

Matched Description: excess tyrosine to accumulate in the blood and urine, tyrosine crystals to form in the cornea, and … increased excretion in the urine of 4-hydroxyphenylpyruvic acid, hydroxyphenyllactic acid, and p … -hydroxyphenylacetic acid. Symptoms commonly appear in early childhood and include: mental retardation … , photophobia (increased sensitivity to light), excessive tearing, eye redness and pain and skin … lesions of the palms and soles. The patient is treated with restriction of dietary phenylalanine and

Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]

Matched Description: excess tyrosine to accumulate in the blood and urine, tyrosine crystals to form in the cornea, and … increased excretion in the urine of 4-hydroxyphenylpyruvic acid, hydroxyphenyllactic acid, and p … -hydroxyphenylacetic acid. Symptoms commonly appear in early childhood and include: mental retardation … , photophobia (increased sensitivity to light), excessive tearing, eye redness and pain and skin … lesions of the palms and soles. The patient is treated with restriction of dietary phenylalanine and

Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]

Matched Description: hypothalamus, and the pituitary. By those binding, this drug reduces the secretion of GnRH from the … increases the viscosity of the cervical mucus. This blocks the passage of spermatozoa and alters the

Matched Protein Synonyms: 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD … 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD

Matched Compound Synonyms: 20-iso-cholesterol … (3b)-3-hydroxy-pregn-5-en-20-one … 3-hydroxypregn-5-en-20-one … 3b-hydroxypregn-5-en-20-one … 3beta-hydroxypregn-5-en-20-one

Matched Description: contraception, prevention of endometrial hyperplasia (hormone replacement therapy), and in the treatment of … greater potency. This drug acts by altering the cervical and endometrial function, as well as it … inhibits the pituitary hormones, like the Follicle-stimulating hormone (FSH) and the Luteinizing … hormone (GnRH) production in the hypothalamus. The low levels of LH and FSH result in the inhibition of … the production of estrogen in the ovaries, thus inhibiting follicular maturation, ovulation, and

Matched Protein Synonyms: 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD … 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD

Matched Compound Synonyms: 20-iso-cholesterol … (3b)-3-hydroxy-pregn-5-en-20-one … 3-hydroxypregn-5-en-20-one … 3b-hydroxypregn-5-en-20-one … 3beta-hydroxypregn-5-en-20-one

Matched Description: and peripheral resistance (that will lead to increasing blood pressure) via aldosterone secretion … decreasing blood pressure. For more information on the effects of aldosterone on electrolyte and water … the mechanism of direct aldosterone antagonists. Eprosartan is an effective agent for reducing blood … pressure and may be used to treat essential hypertension and heart failure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone