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Matched Description: liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms … aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide … mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA … through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

Matched Description: Brexanolone can be found under the brand name Zulresso, and it is the first drug to have ever been … , worthlessness or guilt, cognitive impairment, and/or possibly suicidal ideation, it is considered a life … effects on the maternal-infant bond and later infant development. The development and availability … of brexanolone for the treatment of PPD in adult females subsequently provides a new and promising … anti-depressive medications elicit actions that may modulate the presence and activity of

Matched Protein Synonyms: GABA and glycine transporter

Matched Compound Synonyms: 3alpha-oh dhp … Allopregnan-3alpha-ol-20-one … (3a,5a)-3-hydroxypregnan-20-one … (3α,5α)-3-hydroxypregnan-20-one … (+)-3a-hydroxy-5a-pregnan-20-one

Matched Description: Cyclophosphamide is an antineoplastic alkylating agent used to treat lymphoma and leukemia … order to be activated by various enzymes and cytochrome p450 isoforms (2A6, 2B6, 3A4, 2C9, 2C18, 2C19 … degraded into acrolein and carboxyphosphamide but more importantly it turns into phosphoramide … trying to replace the alkylated bases with new ones. This prevents DNA synthesis and RNA … transcription as the DNA is damaged and cannot be read properly. Phosphoramide mustard also works by creating

Matched Protein Synonyms: Cytochrome P450 MP-20

Matched Compound Synonyms: [oh(oh)] … Magnacide h and b

Matched Description: cholesterol. Aldosterone then goes to act on the distal convoluted tubule and the collecting duct to make … regulating fluid homeostasis and blood pressure. It is involved in various means to increase the body's … blood pressure, hence why it is a target for many pharmceutical drugs that treat hypertension and … vasoconstriction and a subsequent increase in blood pressure. However, it can also influence the blood pressure … in the supraoptic nuclei and they travel down the neurosecretory neuron axon to be stored in the

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and … increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Moexipril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Quinapril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: and peripheral resistance (that will lead to increasing blood pressure) via aldosterone secretion … decreasing blood pressure. For more information on the effects of aldosterone on electrolyte and water … the mechanism of direct aldosterone antagonists. Eprosartan is an effective agent for reducing blood … pressure and may be used to treat essential hypertension and heart failure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: and peripheral resistance (that will lead to increasing blood pressure) via aldosterone secretion … decreasing blood pressure. For more information on the effects of aldosterone on electrolyte and water … the mechanism of direct aldosterone antagonists. Irbesartan is an effective agent for reducing blood … pressure and may be used to treat essential hypertension and heart failure.

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: cholesterol. Aldosterone then goes to act on the distal convoluted tubule and the collecting duct to make … regulating fluid homeostasis and blood pressure. It is involved in various means to increase the body's … blood pressure, hence why it is a target for many pharmceutical drugs that treat hypertension and … vasoconstriction and a subsequent increase in blood pressure. However, it can also influence the blood pressure … in the supraoptic nuclei and they travel down the neurosecretory neuron axon to be stored in the

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone