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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 517624 results

SMP0125168

Pw126709 View Pathway
Metabolite

Dextromethorphan NMDA Antagonism Action Pathway

Homo sapiens

  • Matched Description: receptors, nicotinic acetylcholine receptors, and sigma-1 receptors. Dextromethorphan is an agonist … of NMDA and sigma-1 receptors. It is an antagonist of neuronal acetylcholine receptors, especially … subunit 3A and prevents glutamate from binding to the NDMA receptor on the epsilon-2 subunit. This … prevents the calcium channel from opening and allowing calcium into to the post-synaptic neuron. With … reticulum of central nervous system neurons, where they regulate calcium and potassium, but the reason
  • Matched Compound Synonyms: Ammonia (conc 20% or greater) … Tylenol cold and flu multi-symptom … Tylenol cold and flu no drowsiness … Tylenol cold and flu multi-symptom … Tylenol cold and flu no drowsiness

  • Drug Action

    SMP0125601

    Pw127165 View Pathway
    Metabolite

    Warfarin Metabolism

    Homo sapiens

  • Matched Compound Synonyms: Omebeta 20 … Omebeta 20 … Omebeta 20 … Omebeta 20 … Rat and mice bait

  • Metabolic

    SMP0658967

    Missing View Pathway
    Metabolite

    Glutaric Acidemia Type II (GA II)

    Homo sapiens

  • Matched Description: they are converted to acyl-CoA and then shuttled into the mitochondria as acylcarnitine via the … undergoes a series of oxidation reactions. These reactions depend on FAD- and NAD⁺-dependent … -CoA, and finally to acetyl-CoA, which enters the citric acid cycle or supports ketone body … chain. This disruption impairs the oxidation of fatty acids, amino acids, and certain organic acids … , causing the accumulation of acyl-CoA, acylcarnitines, and glutaric acid derivatives. As a result
  • Matched Protein Synonyms: Solute carrier family 25 member 20 … Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
  • Matched Compound Synonyms: Carnipass 20 … Carnipass 20

  • Disease

    SMP0002358

    Pw002451 View Pathway
    Metabolite

    The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria

    Homo sapiens

  • Matched Description: producing mutIDH1 and mutIDH2 in the cytosolic and mitochondrial isoforms of isocitrate dehydrogenase … , including histone lysine demethylases (KDMs) and the ten-eleven translocation (TET) family of 5 … -methylcytosine (5mC) hydroxylases. This results in modulations of HIF-mediated hypoxia responses and … -ketoglutaric acid. L-2-Hydroxyglutarate is an oncometabolite and is produced by gain-of-function IDH mutations … competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies.
  • Matched Protein Synonyms: F-box and leucine-rich repeat protein 11
  • Matched Compound Synonyms: [co2(oh)](-) … Ammonia (conc 20% or greater)

  • Disease

    SMP0000029

    Pw000007 View Pathway
    Metabolite

    Selenoamino Acid Metabolism

    Homo sapiens

  • Matched Description: are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. All phospholipids contain sn … -glycerol-3-phosphate esterified with fatty acids at the sn-1 and sn-2 positions. The reaction starts … phosphatidylglycerophosphatase. These 2 products combine to produce a cardiolipin and an ethanolamine. The L-1 … phosphatidyl-glycerol can also interact with cardiolipin synthase resulting in a glycerol and a cardiolipin.
  • Matched Protein Synonyms: Zrt- and Irt-like protein 8
  • Matched Compound Synonyms: [p(oh)3se] … [po(oh)3] … Ammonia (conc 20% or greater) … [po(oh)3] … [seo2(oh)2]

  • Metabolic

    SMP0658920

    Pw696699 View Pathway
    Metabolite

    Glutaric Acidemia Type I (GA-I)

    Homo sapiens

  • Matched Description: , hydroxylysine, and tryptophan. As a result, toxic substances such as glutaric acid and 3 … neurological problems, including damage to the basal ganglia, which control movement, and can lead to … , and, in severe cases, intellectual disability. The severity of GA1 varies widely; some individuals … periods of illness or stress. Early diagnosis through newborn screening and prompt treatment with a … special diet and supplements can significantly improve outcomes, but lifelong management is necessary to prevent serious complications.
  • Matched Protein Synonyms: Dehydrogenase E1 and transketolase domain-containing protein 1
  • Matched Compound Synonyms: H-trp-oh … H-trp-oh … H-lys-oh … H-lys-oh … 3-oh-anthranilic acid

  • Disease

    SMP0002291

    Pw002359 View Pathway
    Metabolite

    The Oncogenic Action of 2-Hydroxyglutarate

    Homo sapiens

  • Matched Description: . Isocitric acid becomes dehydrogenated by isocitrate dehydrogenase using NADP as a cofactor, and forming … , including glioma and acute myeloid leukemia. This is due to the buildup of 2-hydroxyglutarate, which … inhibits several enzymes which rely on 2-oxoglutaric acid, such as methylcytosine dioxygenase and lysine … -specific demethylase 2A. Both of these enzymes use 2-oxoglutarate to demethylate DNA, and when … , as methylation is used to suppress genes, and can lead to the expression of oncogenes or the
  • Matched Protein Synonyms: F-box and leucine-rich repeat protein 11
  • Matched Compound Synonyms: [co2(oh)](-) … Ammonia (conc 20% or greater)

  • Disease

    SMP0125122

    Pw126660 View Pathway
    Metabolite

    Terbinafine Metabolism

    Homo sapiens

  • Matched Description: steroid hormones, bile acids, and vitamin D. A lack of cholesterol can cause cholesterol jaundice. The … acids, steroids and retinoids. For this reason Terbinafine isn't recommended for pregnant people … , 2B6, 2C8, 2C9, and 2C19 to make hydroxyterbinafine which is metabolized into N … -Desmethylhydroxyterbinafine by CYP450 3A4, 2B6, 1A2, 2C9, 2C8, and 2C19; and it is metabolized into Carboxyterbinafine … by CYP450 1A2, 2B6, 2C8, 2C9, and 2C19. Terbinafine is then also metabolized into N
  • Matched Protein Synonyms: Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20
  • Matched Compound Synonyms: 20-epi-cholesterol … 20-iso-cholesterol

  • Metabolic

    SMP0002359

    Pw002452 View Pathway
    Metabolite

    The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria

    Homo sapiens

  • Matched Description: producing mutIDH1 and mutIDH2 in the cytosolic and mitochondrial isoforms of isocitrate … histone lysine demethylases (KDMs) and the ten-eleven translocation (TET) family of 5 … -methylcytosine (5mC) hydroxylases. This results in modulations of HIF-mediated hypoxia responses and alterations … -hydroxyglutarate is a competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies.
  • Matched Protein Synonyms: F-box and leucine-rich repeat protein 11
  • Matched Compound Synonyms: [co2(oh)](-) … Ammonia (conc 20% or greater)

  • Disease

    SMP0071792

    Pw072808 View Pathway
    Metabolite

    Phosphatidylethanolamine Biosynthesis PE(20:1(13Z)/20:1(13Z))

    Arabidopsis thaliana

  • Matched Description: cell membranes, and contrary to phosphatidylcholine, it is concentrated with phosphatidylserine in … clarity. Instead, they are indicated with a dark green colour and appear to be free floating in the … dehydrogenase [NAD(+)] catalyzes the interconversion of glycerone phosphate (from glycolysis) and glycerol 3 … catalyzes the synthesis of phosphatidylserine from L-serine and a CDP-diacylglycerol. Last
  • Matched Compounds: DG(20:1(13Z)/20:1(13Z)/0:0) … PE(20:1(13Z)/20:1(13Z)) … PA(20:1(13Z)/20:1(13Z)) … LysoPA(20:1(13Z)/0:0) … CDP-DG(20:1(13Z)/20:1(13Z))
  • Matched Compound Synonyms: Dg(20:1/20:1) … Dg(20:1n7/20:1n7) … Dg(20:1w7/20:1w7) … Dag(20:1(13z)/20:1(13z)) … Dag(20:1/20:1)

  • Metabolic