SMP0126541
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Dienogest Action Pathway
Homo sapiens
Matched Description: Dienogest is a semisynthetic progestogen derived from 19-nortestosterone and has antiandrogenic … , which suppresses the effects of oestradiol on both the eutopic and ectopic endometrium (anovulation … like acne and hirsutism. This drug is administered as an oral tablet.
Matched Protein Synonyms: 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD … 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD
Matched Compound Synonyms: 20-iso-cholesterol … (3b)-3-hydroxy-pregn-5-en-20-one … 3-hydroxypregn-5-en-20-one … 3b-hydroxypregn-5-en-20-one … 3beta-hydroxypregn-5-en-20-one
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SMP0125601
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Warfarin Metabolism
Homo sapiens
Matched Compound Synonyms: Omebeta 20 … Omebeta 20 … Omebeta 20 … Omebeta 20 … Rat and mice bait
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SMP0120731
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Tyrosinemia Type 3 (TYRO3)
Rattus norvegicus
Matched Description: causes tyrosine and phenylalanine to accumulate in the blood resulting in increased excretion of … tyrosine in the urine. Tyrosinemia type 3 symptoms include: seizures, mental retardation and intermittent ataxia (occasional loss of balance and coordination).
Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]
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SMP0120513
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Tyrosinemia Type 2 (or Richner-Hanhart Syndrome)
Mus musculus
Matched Description: excess tyrosine to accumulate in the blood and urine, tyrosine crystals to form in the cornea, and … increased excretion in the urine of 4-hydroxyphenylpyruvic acid, hydroxyphenyllactic acid, and p … -hydroxyphenylacetic acid. Symptoms commonly appear in early childhood and include: mental retardation … , photophobia (increased sensitivity to light), excessive tearing, eye redness and pain and skin … lesions of the palms and soles. The patient is treated with restriction of dietary phenylalanine and
Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]
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SMP0125605
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Tyrosinemia Type 3 (TYRO3)
Homo sapiens
Matched Description: causes tyrosine and phenylalanine to accumulate in the blood resulting in increased excretion of … tyrosine in the urine. Tyrosinemia type 3 symptoms include: seizures, mental retardation and intermittent ataxia (occasional loss of balance and coordination).
Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]
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SMP0002291
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The Oncogenic Action of 2-Hydroxyglutarate
Homo sapiens
Matched Description: . Isocitric acid becomes dehydrogenated by isocitrate dehydrogenase using NADP as a cofactor, and forming … , including glioma and acute myeloid leukemia. This is due to the buildup of 2-hydroxyglutarate, which … inhibits several enzymes which rely on 2-oxoglutaric acid, such as methylcytosine dioxygenase and lysine … -specific demethylase 2A. Both of these enzymes use 2-oxoglutarate to demethylate DNA, and when … , as methylation is used to suppress genes, and can lead to the expression of oncogenes or the
Matched Protein Synonyms: F-box and leucine-rich repeat protein 11
Matched Compound Synonyms: [co2(oh)](-) … Ammonia (conc 20% or greater)
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SMP0143652
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Dexamethasone Drug Metabolism Action Pathway
Homo sapiens
Matched Compound Synonyms: Neomycin and polymyxin b sulfates and dexamethasone … Neomycin and polymyxin b sulphates and dexamethasone … Tobramycin and dexamethasone … Neomycin and polymyxin b sulfates and dexamethasone … Neomycin and polymyxin b sulphates and dexamethasone
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SMP0002358
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The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
Homo sapiens
Matched Description: producing mutIDH1 and mutIDH2 in the cytosolic and mitochondrial isoforms of isocitrate dehydrogenase … , including histone lysine demethylases (KDMs) and the ten-eleven translocation (TET) family of 5 … -methylcytosine (5mC) hydroxylases. This results in modulations of HIF-mediated hypoxia responses and … -ketoglutaric acid. L-2-Hydroxyglutarate is an oncometabolite and is produced by gain-of-function IDH mutations … competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies.
Matched Protein Synonyms: F-box and leucine-rich repeat protein 11
Matched Compound Synonyms: [co2(oh)](-) … Ammonia (conc 20% or greater)
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SMP0125122
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Terbinafine Metabolism
Homo sapiens
Matched Description: steroid hormones, bile acids, and vitamin D. A lack of cholesterol can cause cholesterol jaundice. The … acids, steroids and retinoids. For this reason Terbinafine isn't recommended for pregnant people … , 2B6, 2C8, 2C9, and 2C19 to make hydroxyterbinafine which is metabolized into N … -Desmethylhydroxyterbinafine by CYP450 3A4, 2B6, 1A2, 2C9, 2C8, and 2C19; and it is metabolized into Carboxyterbinafine … by CYP450 1A2, 2B6, 2C8, 2C9, and 2C19. Terbinafine is then also metabolized into N
Matched Protein Synonyms: Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20
Matched Compound Synonyms: 20-epi-cholesterol … 20-iso-cholesterol
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SMP0071789
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Phosphatidylethanolamine Biosynthesis PE(20:1(11Z)/20:1(13Z))
Arabidopsis thaliana
Matched Description: cell membranes, and contrary to phosphatidylcholine, it is concentrated with phosphatidylserine in … clarity. Instead, they are indicated with a dark green colour and appear to be free floating in the … dehydrogenase [NAD(+)] catalyzes the interconversion of glycerone phosphate (from glycolysis) and glycerol 3 … catalyzes the synthesis of phosphatidylserine from L-serine and a CDP-diacylglycerol. Last
Matched Compounds: DG(20:1(11Z)/20:1(13Z)/0:0) … PE(20:1(11Z)/20:1(13Z)) … PA(20:1(11Z)/20:1(13Z)) … LPA(20:1(11Z)/0:0) … CDP-DG(20:1(11Z)/20:1(13Z))
Matched Compound Synonyms: Dg(20:1/20:1) … Dg(20:1n9/20:1n7) … Dg(20:1w9/20:1w7) … Dag(20:1(11z)/20:1(13z)) … Dag(20:1/20:1)
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