SMP0111870
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Protein Synthesis: Glycine
Homo sapiens
Matched Proteins: Receptor of activated protein C kinase 1
Matched Protein Synonyms: MPS-1 … Metallopan-stimulin 1 … MPS-1 … Metallopan-stimulin 1
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SMP0111872
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Protein Synthesis: Isoleucine
Homo sapiens
Matched Proteins: Receptor of activated protein C kinase 1
Matched Protein Synonyms: MPS-1 … Metallopan-stimulin 1 … MPS-1 … Metallopan-stimulin 1
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SMP0119304
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Protein Synthesis: Tyrosine
Homo sapiens
Matched Proteins: Receptor of activated protein C kinase 1
Matched Protein Synonyms: MPS-1 … Metallopan-stimulin 1 … MPS-1 … Metallopan-stimulin 1
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SMP0124724
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Sitagliptin Action Pathway
Homo sapiens
Matched Description: sitagliptin slows DPP-4 mediated inactivation of incretins like GLP-1. GLP-1 is then able to go on to … stimulate insulin secretion in beta cells. GLP-1 activates GLP-1 receptors on beta cells, triggering the Gs … biosynthesis, increase beta cell proliferation, decrease beta cell apoptosis and decrease glucagon secretion since these are also effects mediated by GLP-1.
Matched Compounds: Glucagon-like peptide 1 … GLP-1-(9-36) amide
Matched Proteins: Glucagon-like peptide 1 receptor … Adenylate cyclase type 10 … Voltage-dependent L-type calcium channel subunit beta-1
Matched Protein Synonyms: Tissue-specific extinguisher 1 … Sulfonylurea receptor 1 … Calcium channel, L type, alpha-1 polypeptide isoform 4 … Calcium channel voltage-dependent subunit beta 1
Matched Compound Synonyms: (2r)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine … Potassium ion(1+) … Potassium(1+) ion … Potassium(1+) … Potassium ion(1+)
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SMP0125912
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Dolutegravir Action Pathway
Homo sapiens
Matched Description: Dolutegravir is an HIV-1 integrase inhibitor used for the tratement of HIV-1 in combination with
Matched Proteins: Importin subunit beta-1
Matched Protein Synonyms: RAG cohort protein 1 … Karyopherin subunit beta-1 … Organic anion transporter 1 … Renal organic anion transporter 1
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SMP0126340
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Trimethadione Action Pathway
Homo sapiens
Matched Proteins: Glutamate decarboxylase 1 … Adenylate cyclase type 1 … Gamma-aminobutyric acid type B receptor subunit 1
Matched Protein Synonyms: ATP pyrophosphate-lyase 1 … Adenylyl cyclase 1 … Solute carrier family 32 member 1 … Calcium channel, L type, alpha-1 polypeptide isoform 4
Matched Compound Synonyms: 1-amino-propane-1,3-dicarboxylate … 1-amino-propane-1,3-dicarboxylic acid … 1-aminopropane-1,3-dicarboxylate … 1-aminopropane-1,3-dicarboxylic acid … Chloride(1-)
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SMP0126344
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Maprotiline Action Pathway
Homo sapiens
Matched Proteins: Voltage-dependent L-type calcium channel subunit beta-1 … Beta-1 adrenergic receptor
Matched Protein Synonyms: Calcium channel, L type, alpha-1 polypeptide isoform 4 … Calcium channel voltage-dependent subunit beta 1 … Beta-1 adrenoceptor … Beta-1 adrenoreceptor
Matched Compound Synonyms: (r)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol … 4-[(1r)-2-amino-1-hydroxyethyl]-1,2-benzenediol … 4-(2-amino-1-hydroxyethyl)-1,2-benzenediol … L-2-amino-1-(3,4-dihydroxyphenyl)ethanol … 1-dehydroascorbate
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SMP0126470
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Tirofiban Action Pathway (new)
Homo sapiens
Matched Protein Synonyms: Integrin alpha-IIb light chain, form 1 … Integrin alpha-IIb light chain, form 1 … Integrin alpha-IIb light chain, form 1 … Integrin alpha-IIb light chain, form 1
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SMP0125090
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Gamma-Aminobutyric Acid Biosynthesis
Homo sapiens
Matched Description: Glutamate is catalyzed in the neuron with the enzyme Glutamate decarboxylase-1 to synthesize GABA
Matched Proteins: Glutamate decarboxylase 1 … Adenylate cyclase type 1 … Gamma-aminobutyric acid type B receptor subunit 1
Matched Protein Synonyms: ATP pyrophosphate-lyase 1 … Adenylyl cyclase 1 … Solute carrier family 32 member 1 … Calcium channel, L type, alpha-1 polypeptide isoform 4
Matched Compound Synonyms: 1-amino-propane-1,3-dicarboxylate … 1-amino-propane-1,3-dicarboxylic acid … 1-aminopropane-1,3-dicarboxylate … 1-aminopropane-1,3-dicarboxylic acid
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SMP0125333
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Haloperidol Metabolism Pathway
Homo sapiens
Matched Description: formulation.
Haloperidol is extensively metabolised in the liver with only about 1% of the administered
Matched Compounds: 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+)
Matched Proteins: Carbonyl reductase [NADPH] 1 … UDP-glucuronosyltransferase 1-9 … Solute carrier family 22 member 1
Matched Protein Synonyms: NADPH-dependent carbonyl reductase 1 … UDP-glucuronosyltransferase 1-I … UDPGT 1-9 … Organic cation transporter 1
Matched Compound Synonyms: 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine … 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide
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