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Matched Description: Cyclizine is an H1 antihistamine and antiemetic drug used for the prevention and treatment of … nausea, vomiting, and dizziness associated with motion sickness, and vertigo. H1-antihistamines interfere … with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax

Matched Description: uptake by Uga4p, Put4p, and Gap1p. GABA can also be produced via glutamate degradation by the … transaminase and an NAD+-dependent dehydrogenase. This combination of enzymes has been documented in … bacteria and animals and in some plants. Regarding the hydrogenase, NAD-specific variants have been studied from many bacteria, plant and animals.

Matched Description: Alzheimer's and Parkinson's. The drug reversible binds to and inhibits acetylcholinesterase and … cleft. It is metabolized by the enzymes it inhibits and forms the metabolite NAP226-90.

Matched Description: Buclizine is an antihistamine and antiemetic drug for the treatment of allergy symptoms and … prevention of nausea and vomiting. H1-antihistamines interfere with the agonist action of histamine at the … H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such … as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors … in T-cells to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and

Matched Description: deficiency in this enzyme results in accumulation of 3-methoxytyrosine, 5-hydroxy-L-tryptophan, and L … -Dopa in plasma, spinal fluid, and urine; 3-methoxytyramine and dopamine in urine. It also results in … decreased concentrations of homovanillic acid, S-adenosylmethionine, and 5-hydroxytryptophol in … spinal fluid; and epinephrine, norepinephrine in plasma. Symptoms include temperature instability … , hypotonia, mental and motor retardation, and cerebral atrophy.

Matched Description: signalling pathways involved in tumour growth and angiogenesis such as the Ras/Raf pathway and the PI3K … , Fos, and Myc, as well as cyclin D1, which stimulates cell growth and mitosis. Uncontrolled cell … growth and mitosis leads to cancer. Gefitinib acts as an anticancer drug by binding to the intracellular … tyrosine kinase domain of the EGFR and blocking its activity. This in turn inhibits downstream signalling and prevents tumour growth.

Matched Description: deficiency in this enzyme results in accumulation of 3-methoxytyrosine, 5-hydroxy-L-tryptophan, and L … -Dopa in plasma, spinal fluid, and urine; 3-methoxytyramine and dopamine in urine. It also results in … decreased concentrations of homovanillic acid, S-adenosylmethionine, and 5-hydroxytryptophol in … spinal fluid; and epinephrine, norepinephrine in plasma. Symptoms include temperature instability … , hypotonia, mental and motor retardation, and cerebral atrophy.

Matched Description: aggregation and activation. Vorapaxar is administered orally and rapidly absorbs and travels through … the bloodstream. It is metabolized to major metabolites M20 and M19 by CYP3A4 and CYP2J2. This is … then eliminated primarily through feces and urine. Due to the anticoagulant and antiplatelet nature … , herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry … , danshen, piracetam and ginkgo biloba. St.John's Wort should also be avoided as it induces CYP3A metabolism

Matched Description: cardiovascular effects and systemic pulmonary effects. Levobunolol bind to beta1-adrenergic and … beta2-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic … neurotransmitters such as norepinephrine, which lead to decreased blood pressure, heart rate and cardiac output.

Matched Description: airways, and blood vessels. Activation of the H1 receptors causes the stereotypical allergic … , flushing, tachycardia, and bronchoconstriction. Also, H1 receptors regulate sleep-wake cycles … , food intake, thermal regulation, emotions/aggressive behavior, locomotion, memory, and learning.[1 … ] These receptors also mediate most of the effects of histamine that are relevant to asthma and can also … include features of smooth muscle spasms, mucosal edema, inflammation, and mucous secretion