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Matched Description: , reducing pulmonary function and causing symptoms such as difficulty breathing. Although the … M3 receptors results in ASM contraction and resulting bronchoconstriction through downstream calcium … side effects of using methacholine may include headache, sore throat, nausea, and dizziness.

Matched Description: carcinoma, and chronic myelocytic. All the alkylating agents work by three different mechanisms to … . This prevents DNA synthesis and RNA transcription. Secondly, the drug also creates cross-links between … atoms in the DNA, resulting in DNA damage and the impossibility to separate each strand for the

Matched Description: Europe, Russia, and South Korea. It is also approved as an orphan drug by the FDA for the treatment of … soft tissue sarcomas and ovarian cancer. Trabectedin binds covalently to the DNA minor groove. This … molecule binds and alkylates guanine bases to the N2 position with its two rings in its structure

Matched Description: influenza A, B, and Avian. It is specifically a first-in-class cap-dependent endonuclease inhibitor. It is … three subunits: polymerase basic protein 1 (PB1), polymerase basic protein 2 (PB2), and polymerase … epithelium, liver and blood to its active metabolite, baloxavir. Balaxovir selectively inhibits the

Matched Description: The malto dextrin uptake operon involves the genes malK, lamB, and malM. The operon's transcription

Matched Description: incorporation into DNA and RNA as well as by inhibiting thymidylate synthase. Since thymidine

Matched Description: of itraconazole is only 55% and is best when taken with food. Itraconazole is transported from the … cassette sub-family C member 3. Once there, it travels to the liver and is transported in via P … Lanosterol 14-alpha demethylase, the first step in steroid biosynthesis and a very similar enzyme to what it … 3A7, Cytochrome P450 3A4, Cytochrome P450 2B6, and Cytochrome P450 2E1, which are similar to

Matched Description: consists of six iodine atoms and achieves water solubility by ionization; thus, it is a 3.0 ratio

Matched Description: protein. The inhibition of matrix protein 2 prevents the virus from replicating and further infecting cells.

Matched Description: that degrades fibrin clots. In addition to its binding and activation on fibrin clots, PLG also … present in humans - type I plasminogen contains two glycosylation moieties (N-linked to N289 and O … , including tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and … urokinase plasminogen activator. The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562.