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Matched Description: Donepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that … is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or … cholinergic transmission to relieve the symptoms of Alzheimer's and dementia. Normally … through first-pass metabolism by CYP3A4 and CYP2D6 into metabolites which can be further broken down … by dealkylation, hydroxylation, oxidation, hydrolysis and glucuronidation.

Matched Description: enhance the image in cranial and spinal MRIs. It is used with magnetic resonance imaging (MRI) in adults … , and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in … the brain (intracranial lesions), spine and associated tissues as well as lesions with abnormal … vascularity in the head and neck. Also used to facilitate the visualization of lesions with abnormal

Matched Description: , free radicals, and UV irradiation. It can also respond to bacterial and viral antigens; therefore … and immune diseases (and more) can be related to the incorrect regulation of the NF-κB complex. The … ), and the noncanonical (or alternative) pathway, which selectively responds to a specific group of … stimuli, such as groups of ligands of a subset of TNFR superfamily members (e.g. LTβR, BAFFR, CD40 and … RANK). Both pathways are important for regulating immune and inflammatory responses despite their differences in signalling mechanism.

Matched Proteins: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Matched Description: , free radicals, and UV irradiation. It can also respond to bacterial and viral antigens; therefore … and immune diseases (and more) can be related to the incorrect regulation of the NF-κB complex. The … ), and the noncanonical (or alternative) pathway, which selectively responds to a specific group of … stimuli, such as groups of ligands of a subset of TNFR superfamily members (e.g. LTβR, BAFFR, CD40 and … RANK). Both pathways are important for regulating immune and inflammatory responses despite their differences in signalling mechanism.

Matched Proteins: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Matched Description: different phosphoinositides have been identified in mammals, each distinguished by the number and/or … cell, such as actin cytoskeletal reorganization, membrane transport, and cell proliferation. They … may also affect protein localization, aggregation, and activity by acting as secondary messengers. The … signals means that their synthesis and metabolism must be tightly regulated. Synthesis begins with the … a number of specific phosphoinositide kinases and phosphatases, which add (kinase) and remove

Matched Proteins: Autophagy and beclin 1 regulator 1

Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3

Matched Proteins: Peptidase propeptide and YPEB domain protein

Matched Description: effects in many other pathways and processes. This pathway uses 2 distinct steps. The first step is that … . This pathway is important for DNA repair, regulating the amount of proteins, and the creation of antigen-peptide.

Matched Proteins: STIP1 homology and U box-containing protein 1

Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3

Matched Proteins: Xanthine and Co dehydrogenase maturation factor

Matched Description: acid, resulting in a fumaric acid and ubiquinol. Ubiquinone interacts with succinic acid through a … cofactors, ferroheme b, 2FE-2S, FAD, and 3Fe-4S iron-sulfur cluster. Then 2 ubiquinol interact with … oxygen and 4 hydrogen ion through a cytochrome bd-I terminal oxidase resulting in a 4 hydrogen ion … transferred into the periplasmic space, 2 water returned into the cytoplasm and 2 ubiquinone, which … and 4 hydrogen ion through a cytochrome bd-II terminal oxidase resulting in a 4 hydrogen ion

Matched Proteins: Succinate dehydrogenase and fumarate reductase iron-sulfur protein

Matched Description: Indacaterol is an inhaled beta-2 adrenergic agonist that is both rapid onset and long acting. The … purpose of this drug is to relax bronchial smooth muscle to help treat COPD, asthma, and chronic … bronchitis by opening the airways. It can be found under the brand names Hirobriz, Onbrez, and Ultibro … bronchial smooth muscles causing bronchodilator and increased airflow. Once Indacaterol is administered … and it binds to and activates the beta-2 adrenergic receptor, the G protein signalling cascade