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Matched Description: (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Trimebutine is a … spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with … antimuscarinic and weak mu opioid agonist effects. It is marketed for the treatment of irritable bowel … syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most … common multifactorial GI disorders. It is used to restore normal bowel function and is commonly

Matched Description: cells tend to overexpress VEGF, which stimulates angiogenesis, facilitating cancer growth and … endothelial cell surfaces. Upon binding, the receptor autophosphorylates and initiates a signalling … MAP kinase kinase, which phosphorylates MAP kinase. The activated MAP kinase enters the nucleus and … , migration, permeability, invasion, and survival. Binding of VEGF to VEGFR-2 also activates phospholipase C … PIP2 into DAG and IP3. DAG may be involved in the activation of Raf-1 leading to angiogenesis

Matched Description: Folate biosynthesis is a pathway by which pterin and pABA precursors form tetrahydrofolate, an … . Although tetrahydrofolate is synthesized in the mitochondrial matrix, the pterin and pABA branches … occur in the cytosol and the chloroplast, respectively. The first reaction in the pABA branch is … catalyzed by aminodeoxychorismate synthase (ADCS) whereby chorismate and L-glutamine is converted to … aminodeoxychorismate and L-glutamic acid. The second reaction in the pABA branch is catalyzed by

Matched Description: receptors and beta2-adrenergic receptors. Blocking of beta1-adrenergic receptors in heart and vascular … smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure. Blocking

Matched Description: cells and binds to the 30S ribosomal subunit. By binding to 30S subunit which prevents tRNA binding to … mRNA ribosome complex and disrupting protein synthesis. Milk and dairy products should be avoided

Matched Description: Lomefloxacin is a fluoroquinolone used to prevent and treat a wide variety of infections in the … body. Lomefloxacin inhibits DNA gyrase (topoisomerase II) and topoisomerase IV. These proteins prevent … supercoiling in bacterial DNA. The inhibition of DNA gyrase (topoisomerase II) and topoisomerase IV

Matched Description: palliative treatment of various cancers like brain tumors, multiple myeloma, Hodgkin's disease, and Non … -Hodgkin's lymphomas. This drug causes cross-links in DNA and RNA. This results in the inhibition of DNA … and RNA synthesis and protein synthesis. Furthermore, carmustine also binds and carbamoylates the … . Therefore, the enzyme protects the cell against lipid peroxides, reactive oxygen, and nitrogen … species, and xenobiotics (inhibition of ferroptosis). This drug induces apoptosis of cancerous cell in a

Matched Description: was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … . It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In Escherichia … coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs 2 … and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with

Matched Description: It was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In … Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding … to PBPs 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by

Matched Description: It was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be … effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria … action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In … Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding … to PBPs 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by