SMP0000118
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Torsemide Action Pathway
Homo sapiens
Matched Description: the drug class of loop diuretics. It is commonly used to manage hypertension and edema in cases of … reduces the uptake of water and serves to both increase water loss and reduce blood pressure
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000583
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Blue Diaper Syndrome
Homo sapiens
Matched Description: symptoms can include bacterial infections, damage to various parts of the eye, hypercalcemia, and impaired … hypercalcemia, and a tryptophan restricted diet to prevent all systems. If bacterial infections are common, antibiotics may be prescribed.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000197
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Lysinuric Protein Intolerance
Homo sapiens
Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000189
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Hartnup Disorder
Homo sapiens
Matched Description: -isoleucine, L-leucine, L-phenylalanine, L-serine, L-threonine, L-tryptophan, L-valine, and L-tyrosine in … urine. Symptoms include pellagra, psychosis, ataxia, and mental retardation. Treatment includes nicotinamide.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000105
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Metolazone Action Pathway (old)
Homo sapiens
Matched Description: chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000132
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Triamterene Action Pathway
Homo sapiens
Matched Description: used to manage hypertension and edema. It acts by blocking epithelial sodium channels in the late … in the nephron. This primarily contributes to an increase in sodium excretion and consequentially … , fluid excretion which decreases blood volume and blood pressure. Potassium secretion is indirectly … action for potassium-sparing drugs -- and has the potential to induce hyperkalemia which can potentially lead to severe heart arrhythmias.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000081
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Methyclothiazide Action Pathway
Homo sapiens
Matched Description: chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000121
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Trichlormethiazide Action Pathway
Homo sapiens
Matched Description: called thiazides. Thiazides and thiazide-like drugs are diuretics commonly employed to control … hypertension. Trichloromethiazide acts by inhibiting chloride and potentially sodium reabsorption in the … increased fluid loss which ultimately reduces blood volume and pressure. Trichlormethiazide also acts … to inhibit sodium uptake and increase potassium excretion which also serves to increase fluid loss … . The long-term antihypertensive effects of thiazides and thiazide-like drugs such as
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000193
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Iminoglycinuria
Homo sapiens
Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000184
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Glucose Transporter Defect (SGLT2)
Homo sapiens
Matched Description: responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 … kidney. There are some drugs that inhibit SGLT2 and are used to decrease blood sugar in patients with type 2 diabetes mellitus.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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