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Matched Description: (loratadine). H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are … , allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response … transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also … decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion … molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased

Matched Description: (terfenadine). H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are … , allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response … transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also … decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion … molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased

Matched Description: . Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and … H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such … as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors … in T-cells to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and … in smooth muscles of lungs and intestines to relax those muscles. Allergies causes blood vessel

Matched Description: dependent on the concentration of bovine thrombin and fibrinogen present. It is metabolized in the … as a topical and then cleared via thrombin inhibitor complexes and or through internalization and degradation by the endothelium.

Matched Description: cancer, pancreatic cancer, breast cancer, and cervical cancer. As a cream, it is used for actinic … keratosis, basal cell carcinoma, and skin warts. Fluorouracil is on the World Health Organization's List … of Essential Medicines, the most effective and safe medicines needed in a health system … . Fluorouracil exerts cytotoxic effects on the cell by direct incorporation into DNA and RNA as well as by inhibiting thymidylate synthase.

Matched Description: , accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the … liver and UGT1A10 in the gut. APAP can also by metabolized via sulfation, accounting for 30-35% of the … , SULT1E1 and SULT2A1. Moreover, APAP can also be activated to form the toxic N-acetyl-p-benzoquinone … imine (NAPQI) under the mediation of CYP3A4, CYP2E1, CYP2D6 CYP1A2, CYP2E1 and CYP2A6.

Matched Description: mitochondrial beta-oxidation of long chain fatty acids. HADHA converts medium- and long-chain 2-enoyl-CoA … compounds into the corresponding 3-ketoacyl-CoA compounds when NAD is present, and acetyl-CoA when … NAD and CoASH are present. Deficiencies in this enzyme prevent the body from converting certain fats … to energy, particularly during periods without food (fasting). Signs and symptoms of LCHAD … deficiency typically manifest during infancy or early childhood and can include feeding difficulties

Matched Description: Hydrocodone is an opioid agonist used as an analgesic and antitussive agent. It is a synthetic … and allergic rhinitis in combination with decongestants, antihistamines, and expectorants … . Hydrocodone inhibits pain signaling in both the spinal cord and brain. Its actions in the brain also produce … euphoria, respiratory depression, and sedation. Hydrocodone binds to mu opioid receptors … and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP

Matched Description: mitochondrial beta-oxidation of long chain fatty acids. HADHA converts medium- and long-chain 2-enoyl-CoA … compounds into the corresponding 3-ketoacyl-CoA compounds when NAD is present, and acetyl-CoA when … NAD and CoASH are present. Deficiencies in this enzyme prevent the body from converting certain fats … to energy, particularly during periods without food (fasting). Signs and symptoms of LCHAD … deficiency typically manifest during infancy or early childhood and can include feeding difficulties

Matched Description: target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1 … , and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late … the mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single … generates nonstructural proteins NS3, NS4A, NS4B, NS5A, and NS5B. These proteins are required in … concentration above their antiviral half-maximal effective concentration (EC50), Paritaprevir and other