SMP0126743
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Tobramycin Action Pathway (new)
Homo sapiens
Matched Description: fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, and bone infections … bacterial membranes causing displacement of divalent cations and increasing membrane permeability … bacterial 30S ribosome and binds to it, halting protein synthesis. It binds to the site where the … normal base pairing of codon and anti-codon takes place as well as adding amino acids to the growing … polypeptide chain, with this blocked it leads to termination of the chain and production of non
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SMP0126826
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Levacetylmethadol Opioid Agonist Action Pathway
Homo sapiens
Matched Description: with a long onset and duration of action. It was withdrawn from the European Union due to its high … system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids … neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited … . Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly … rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. Morphine
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SMP0126892
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Iodipamide Metabolism
Homo sapiens
Matched Description: Iodipamide is a contrast agent used in cholangiography and cholecystography. Organic iodine … (concentration and volume) of the iodinated contrast agent in the path of the x-rays. Iodipamide's primary … excretion through the hepato-biliary system and concentration in bile allows visualization of the … gallbladder and biliary ducts. iodipamide is carried to the liver where it is rapidly secreted. The … of the hepatic and common bile ducts, even in cholecystectomized patients. The biliary ducts are
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SMP0127007
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Carboprost tromethamine Action Pathway
Homo sapiens
Matched Description: Carboprost tromethamine is a medication primarily used in obstetrics and gynecology for two … , typically between the 13th and 20th weeks of gestation. This is indicated when other methods of … of abortion and provide hemostasis in postpartum hemorrhage. However, it can also lead to side … effects such as vomiting, diarrhea, transient temperature increases, and, in some cases … procedure carried out under specific circumstances and should only be administered by trained healthcare
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SMP0125325
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Methyldopa Metabolism Pathway
Homo sapiens
Matched Description: in combination with hydrochlorothiazide, and to treat hypertensive crises.
Methyldopa is … -dihydroxyphenylacetone; α-methyldopamine; and 3-O-methyl-α-methyldopamine. These metabolites are further … prominent metabolites are alpha-methyldopamine and the glucuronide of dihydroxyphenylacetone, along with … as unchanged parent drug (24%) and α-methyldopa mono-O-sulfate (64%), with variability.3-O-methyl-α … -dihydroxyphenylacetone, α-methyldopamine, and 3-O-methyl-α-methyldopamine and their conjugates are also excreted in urine.
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SMP0124566
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Tacrolimus Action Pathway
Homo sapiens
Matched Description: like ABCB1 and works by forming a complex with FKBP12 with inhibits calcineurin with leads to … reduced T cell signal transduction and IL-2 transcription. IL-2 is an important mediator for T-cell … activation, differentiation and migration which is through mTOR signalling. Lower IL-2 production and … also inhibits the transcription for genes encoding IL-3,4,5, GM-SCF, and TNF as well which are also … transplant for liver, kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea and limb transplant.
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SMP0125240
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Drotaverine Action Pathway
Homo sapiens
Matched Description:
Drotaverine is a phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and … activating M3 muscarinic receptors. M3 muscarinic receptors are coupled to Gq protein, and thus … -triphosphate (IP3) and diacylglycerol. IP3 stimulates IP3 receptors on the endoplasmic reticulum(ER … kinase, thereby inactivating it and preventing it’s phosphorylation of myosin light chain. This leads … to an accumulation of unphosphorylated myosin light chain and ultimately, muscle relaxation
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SMP0125831
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Posaconazole Action Pathway
Homo sapiens
Matched Description: species and Aspergillus species in severely immunocompromised patients. For prophylaxis of invasive … Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of … of the triazolone side chain. These modifications enhance the potency and spectrum of activity of … cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells … . This leads to cell lysis which causes it to collapse and die.
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SMP0126081
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Vinblastine Action Pathway (New)
Homo sapiens
Matched Description: agent. It is used as a treatment of breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non … -Hodgkins lymphoma, mycosis fungoides, histiocytosis and Kaposi's sarcoma. Its antitumor activity is … proteins; cellular tumor antigen p53 and cyclin dependent kinase inhibitor p21. The latter protein … on BAK and BAX to enact conformational changes, creating pores in the mitochondrial membrane that … essential cellular proteins. In this way, p53 and p21 work alongside each other to promote apoptosis and terminate unhealthy cells.
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SMP0126650
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Propranolol B2-Adrenergic Vasoconstriction Action Pathway
Homo sapiens
Matched Description: On the World Health Organization's List of Essential Medicines and a prototypical drug of its class … , propranolol is a non-cardioselective beta blocker and it is typically synthesized as a racemic … it passes through hepatic portal circulation, and enters the bloodstream to act on peripheral cells … , and pheochromocytoma. It can be found under the brand names Hemangeol, Hemangiol, Inderal, and … muscle contraction (vasoconstriction in this case). Some side effects of using propranolol may include dizziness, tiredness, and difficulties sleeping.
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