SMP0120867
View Pathway
|
Lysinuric Protein Intolerance (LPI)
Rattus norvegicus
Matched Description: of metabolism (IEM) and autosomal recessive disorder of the kidney function pathway. It is caused … involved in the uptake of amino acids, both with sodium for neutral amino acids, and without for … dibasic amino acids. In this disorder, the amino acids lysin, arginine and ornithine, found in protein … urea cycle. LPI is characterized by a shortage of lysine, arginine and ornithine within the body … after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120874
View Pathway
|
Cystinuria
Rattus norvegicus
Matched Description: in the kidneys. The mutations cause this process to be compromised and allows the amino acids to … build up and have a high concentration in urine. This causes crystals to form and become stones as they … , develop infection and disrupt the passing of urine through the urinary tract if the stones create a blockage there.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0119387
View Pathway
|
Kidney Function
Rattus norvegicus
Matched Description: angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an … , nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid … volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium … , chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending … loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0119367
View Pathway
|
Kidney Function
Mus musculus
Matched Description: angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an … , nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid … volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium … , chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending … loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120547
View Pathway
|
Iminoglycinuria
Mus musculus
Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120483
View Pathway
|
Glucose Transporter Defect (SGLT2)
Mus musculus
Matched Description: responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 … kidney. There are some drugs that inhibit SGLT2 and are used to decrease blood sugar in patients with type 2 diabetes mellitus.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0121001
View Pathway
|
Kidney Function- Proximal Convoluted Tubule
Homo sapiens
Matched Description: The proximal convoluted tubule is part of the nephron between the Bowman's capsule and the loop of … Henle. The proximal convoluted tubule functions to reabsorb sodium, water, and other ions. Sodium … and bicarbonate (hydrogen carbonate) are transported by a co-transporter that is responsible for the … and apical membranes, respectively, to effectively regulate the pH of the filtrate. In addition … occurrence explains solute movement secondary to water flow. All the cation and anion transport
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120768
View Pathway
|
Lysinuric Protein Intolerance
Rattus norvegicus
Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0126112
View Pathway
|
Dexibuprofen Action Pathway
Homo sapiens
Matched Description: -steroidal anti-inflammatory drug (NSAID). It is used to treat pain and inflammation in many conditions … (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxygenase … , and during inflammation, it is responsible for prostaglandin synthesis. It leads to the formation … immune cells and for increasing pain sensation by acting on pain fibers. Dexibuprofen inhibits the … action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of
Matched Compound Synonyms: Fa(20:4(5z,8z,11z,14z)) … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability. … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability.
|
SMP0120767
View Pathway
|
Iminoglycinuria
Rattus norvegicus
Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|