SMP0124967
View Pathway
|
Irbesartan Angiotensin blocker Action Pathway
Homo sapiens
Matched Description: the kidney are responsible for the production of aldosterone which increases salt and water retention … that has powerful vasoconstrictive effects and increases blood pressure. Irbesartan is used to treat … hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure … vessels, kidneys, hypothalamus, and posterior pituitary.
In blood vessels AT1 receptors cause … which increases blood volume. Blocking AT1 receptors reduces aldosterone production allowing water
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0122803
View Pathway
|
Benazepril ACE inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Benazepril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0120547
View Pathway
|
Iminoglycinuria
Mus musculus
Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120867
View Pathway
|
Lysinuric Protein Intolerance (LPI)
Rattus norvegicus
Matched Description: of metabolism (IEM) and autosomal recessive disorder of the kidney function pathway. It is caused … involved in the uptake of amino acids, both with sodium for neutral amino acids, and without for … dibasic amino acids. In this disorder, the amino acids lysin, arginine and ornithine, found in protein … urea cycle. LPI is characterized by a shortage of lysine, arginine and ornithine within the body … after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120874
View Pathway
|
Cystinuria
Rattus norvegicus
Matched Description: in the kidneys. The mutations cause this process to be compromised and allows the amino acids to … build up and have a high concentration in urine. This causes crystals to form and become stones as they … , develop infection and disrupt the passing of urine through the urinary tract if the stones create a blockage there.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120648
View Pathway
|
Lysinuric Protein Intolerance (LPI)
Mus musculus
Matched Description: of metabolism (IEM) and autosomal recessive disorder of the kidney function pathway. It is caused … involved in the uptake of amino acids, both with sodium for neutral amino acids, and without for … dibasic amino acids. In this disorder, the amino acids lysin, arginine and ornithine, found in protein … urea cycle. LPI is characterized by a shortage of lysine, arginine and ornithine within the body … after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120655
View Pathway
|
Cystinuria
Mus musculus
Matched Description: in the kidneys. The mutations cause this process to be compromised and allows the amino acids to … build up and have a high concentration in urine. This causes crystals to form and become stones as they … , develop infection and disrupt the passing of urine through the urinary tract if the stones create a blockage there.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120703
View Pathway
|
Glucose Transporter Defect (SGLT2)
Rattus norvegicus
Matched Description: responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 … kidney. There are some drugs that inhibit SGLT2 and are used to decrease blood sugar in patients with type 2 diabetes mellitus.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0120766
View Pathway
|
Hartnup Disorder
Rattus norvegicus
Matched Description: -isoleucine, L-leucine, L-phenylalanine, L-serine, L-threonine, L-tryptophan, L-valine, and L-tyrosine in … urine. Symptoms include pellagra, psychosis, ataxia, and mental retardation. Treatment includes nicotinamide.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|
SMP0119367
View Pathway
|
Kidney Function
Mus musculus
Matched Description: angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an … , nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid … volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium … , chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending … loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
|