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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 191662 results

SMP0120867

Pw122128 View Pathway
Metabolite

Lysinuric Protein Intolerance (LPI)

Rattus norvegicus

  • Matched Description: of metabolism (IEM) and autosomal recessive disorder of the kidney function pathway. It is caused … involved in the uptake of amino acids, both with sodium for neutral amino acids, and without for … dibasic amino acids. In this disorder, the amino acids lysin, arginine and ornithine, found in protein … urea cycle. LPI is characterized by a shortage of lysine, arginine and ornithine within the body … after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Disease

    SMP0120874

    Pw122135 View Pathway
    Metabolite

    Cystinuria

    Rattus norvegicus

  • Matched Description: in the kidneys. The mutations cause this process to be compromised and allows the amino acids to … build up and have a high concentration in urine. This causes crystals to form and become stones as they … , develop infection and disrupt the passing of urine through the urinary tract if the stones create a blockage there.
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Disease

    SMP0119387

    Pw120610 View Pathway
    Metabolite

    Kidney Function

    Rattus norvegicus

  • Matched Description: angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an … , nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid … volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium … , chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending … loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Physiological

    SMP0119367

    Pw120590 View Pathway
    Metabolite

    Kidney Function

    Mus musculus

  • Matched Description: angiotensin II and aldosterone, which increases sodium chloride reabsorption. This results in an … , nutrient reabsorption, and regulating electrolyte concentrations, acid-base balance, extracellular fluid … volume, and blood pressure. The early proximal tubule is where glucose, amino acids, sodium … , chlorine, phosphate, bicarbonate, and water are reabsorbed. Only water is reabsorbed in the thin descending … loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Physiological

    SMP0120547

    Pw121803 View Pathway
    Metabolite

    Iminoglycinuria

    Mus musculus

  • Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Disease

    SMP0120483

    Pw121735 View Pathway
    Metabolite

    Glucose Transporter Defect (SGLT2)

    Mus musculus

  • Matched Description: responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 … kidney. There are some drugs that inhibit SGLT2 and are used to decrease blood sugar in patients with type 2 diabetes mellitus.
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Disease

    SMP0121001

    Pw122268 View Pathway
    Metabolite

    Kidney Function- Proximal Convoluted Tubule

    Homo sapiens

  • Matched Description: The proximal convoluted tubule is part of the nephron between the Bowman's capsule and the loop of … Henle. The proximal convoluted tubule functions to reabsorb sodium, water, and other ions. Sodium … and bicarbonate (hydrogen carbonate) are transported by a co-transporter that is responsible for the … and apical membranes, respectively, to effectively regulate the pH of the filtrate. In addition … occurrence explains solute movement secondary to water flow. All the cation and anion transport
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Physiological

    SMP0120768

    Pw122029 View Pathway
    Metabolite

    Lysinuric Protein Intolerance

    Rattus norvegicus

  • Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Disease

    SMP0126112

    Pw127691 View Pathway
    Metabolite

    Dexibuprofen Action Pathway

    Homo sapiens

  • Matched Description: -steroidal anti-inflammatory drug (NSAID). It is used to treat pain and inflammation in many conditions … (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxygenase … , and during inflammation, it is responsible for prostaglandin synthesis. It leads to the formation … immune cells and for increasing pain sensation by acting on pain fibers. Dexibuprofen inhibits the … action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of
  • Matched Compound Synonyms: Fa(20:4(5z,8z,11z,14z)) … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability. … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability.

  • Drug Action

    SMP0120767

    Pw122028 View Pathway
    Metabolite

    Iminoglycinuria

    Rattus norvegicus

  • Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.
  • Matched Compounds: Aldosterone
  • Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
  • Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

  • Disease