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Pathway Description
Ion Channels and Their Functional Role in Vascular Endothelium
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Transport/Degradation
Cellular Response
Created: 2018-08-31
Last Updated: 2019-08-16
In endothelial cell, ion channels such as agonist-activated nonselective Ca(2+)-permeable cation channels, cyclic nucleotide-activated nonselective cation channels, and store-operated Ca(2+) channels or capacitative Ca(2+) entry are controlled by intracellular Ca(2+) signals. Some of the channels are expressed by trp gene family. Ca(2+) entry is also controlled by large-conductance Ca(2+)-dependent BK(Ca) channels (slo), inwardly rectifying K(+) channels, Ca(2+)-activated Cl(-) channel and volume-regulated anion channel (VRAC). VRAC channels can also transport organic osmolytes and amino acid.
References
Ion Channels and Their Functional Role in Vascular Endothelium References
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This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063778
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