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454-29-5 CAS 17215925 ChemSpider 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 439161 PubChem-compound SMILES N[C@@H](CS)C(O)=O Methionine synthase CYS BioCyc Cystathionine gamma-synthase C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 Succinic acid C05330 KEGG Compound SMILES N[C@@H](CCO)C(O)=O CHEBI:58207 ChEBI Methionine Biosynthesis CHEBI:58020 ChEBI 1.0 HMDB0000099 HMDB Homoserine O-succinyltransferase SMILES C[S+](C)CCC(N)C(O)=O C00441 KEGG Compound CHEBI:17230 ChEBI 6137 PubChem-compound Homocysteine S-methyltransferase 6816 PubChem-compound 2.0 49791978 PubChem-compound SMILES NC(=C)C([O-])=O 53-59-8 CAS SMILES N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O CHEBI:15380 ChEBI SMILES [H][C@@](CCC([O-])=N[C@@]([H])(CCC([O-])=N[C@@]([H])(CCC([O-])=O)C(O)=O)C(O)=O)(NC(=O)C1=CC=C(NC[C@@]2([H])CNC3=C(N2C)C([O-])=NC(=N)N3)C=C1)C(O)=O L-Methionine C25H40N7O19P3S Succinyl-CoA 867.1312 1038 PubChem-compound CHEBI:17561 ChEBI SMILES CSCC[C@H](N)C(O)=O CHEBI:16474 ChEBI P00935 UniProt GO:0005829 GENE ONTOLOGY 1.0 C04144 KEGG Compound L-CYSTATHIONINE BioCyc P23256 UniProt 1.0 1.0 2.1.1.10 false 2.1.1.10 Homocysteine + S-Methylmethionine ↔ Hydrogen Ion + 2 L-Methionine REVERSIBLE Bifunctional aspartokinase/homoserine dehydrogenase 2 Bifunctional aspartokinase/homoserine dehydrogenase 1 2.7.2.4 false 2.7.2.4 Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP LEFT_TO_RIGHT 1.0 NADPH 5862 PubChem-compound 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS NADP 13065-25-3 CAS P25665 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:58140 ChEBI C21H29N7O17P3 NADP 744.08325 SMP0000794 SMPDB SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 SubPathwayInteraction1649 SubPathway1649Reaction SubPathwayReaction P07623 UniProt NADPH BioCyc Hydrogen Ion C8H13NO6 O-succinyl-L-homoserine 219.07428 C3H4NO2 2-aminoprop-2-enoate 86.02475 672-15-1 CAS Cytosol 2.0 C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 SUC BioCyc ReactionCatalysis2853 ACTIVATION HMDB0000574 HMDB HMDB0001423 HMDB ReactionCatalysis2855 ACTIVATION ReactionCatalysis2854 ACTIVATION HMDB0000696 HMDB ReactionCatalysis2857 ACTIVATION ReactionCatalysis2856 ACTIVATION ReactionCatalysis2859 ACTIVATION HMDB0000217 HMDB ReactionCatalysis2858 ACTIVATION 1.0 PW000771 PathWhiz Cystathionine gamma-synthase C00006 KEGG Compound P00561 UniProt CHEBI:18009 ChEBI Hydrogen Ion 16722112 PubChem-compound P00562 UniProt C29H37N9O12 Tetrahydropteroyltri-L-glutamate 703.25616 C00005 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 445 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 53-57-6 CAS CHEBI:15741 ChEBI 1.0 Homocysteine S-methyltransferase CHEBI:17482 ChEBI 1.0 C00010 KEGG Compound Tetrahydropteroyltri-L-glutamate 1.0 1110 PubChem-compound 1.0 NAD(P) BioCyc GO:0005620 GENE ONTOLOGY SMILES NC(CCS)C(O)=O C4H6O4 Succinic acid 118.02661 562 TAXONOMY 12126 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider TransportCatalysis392 ACTIVATION 458 PubChem-compound CPD-1302 BioCyc CHEBI:16160 ChEBI C00263 KEGG Compound MET BioCyc N5-methyl--tetrahydropteroyl tri-L-glutamate 2.0 5653 ChemSpider 56-88-2 CAS 1.0 L-Cystathionine 1.0 SMILES N[C@@H](CC=O)C(O)=O C7H14N2O4S L-Cystathionine 222.06743 1.0 ReactionCatalysis2884 ACTIVATION S-Methylmethionine C5H11NO2S L-Methionine 149.05106 1.0 52-90-4 CAS L-Homoserine CHEBI:1146900 ChEBI HMDB0000254 HMDB SMILES OC(=O)CCC(O)=O Protein malY Lysine Biosynthesis SubPathway CHEBI:15699 ChEBI HMDB0012249 HMDB CO-A BioCyc C00042 KEGG Compound 5675 ChemSpider Uncharacterized protein YbjE 1078 ChemSpider L-Cysteine 1.0 Coenzyme A 1.0 604-98-8 CAS C21H36N7O16P3S Coenzyme A 767.11523 2.0 SMILES N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O 4.0 aspartate kinase / homoserine dehydrogenase 6557 ChemSpider Cystathionine beta-lyase metC Escherichia coli 12647 PubChem-compound 17625690 ChemSpider 2.3.1.46 false 2.3.1.46 L-Homoserine + Succinyl-CoA → Coenzyme A + O-succinyl-L-homoserine LEFT_TO_RIGHT 63-68-3 CAS 5907 ChemSpider SMP0000834 SMPDB CHEBI:16643 ChEBI 1.0 N5-methyl--tetrahydropteroyl tri-L-glutamate Methionine synthase 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase O-succinyl-L-homoserine 2-aminoprop-2-enoate L-Methionine HMDB0000719 HMDB 1.0 C00073 KEGG Compound 4.0 1.0 388392 ChemSpider CHEBI:17420 ChEBI L-Methionine Homoserine O-succinyltransferase 439235 PubChem-compound C00080 KEGG Compound 110-15-6 CAS Periplasmic Space 4.0 15106-57-7 CAS Uncharacterized protein YbjE PW000814 PathWhiz HMDB0001022 HMDB C4H9NO2S Homocysteine 135.0354 ReactionCatalysis5840 ACTIVATION CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA Protein malY 5886 PubChem-compound HOMO-CYS BioCyc 2.1.1.13 false 2.1.1.13 Homocysteine + N5-methyl--tetrahydropteroyl tri-L-glutamate → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT C00091 KEGG Compound 2.1.1.13 false 2.1.1.13 N5-methyl--tetrahydropteroyl tri-L-glutamate + Homocysteine → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT P75826 UniProt 2.5.1.48 false 2.5.1.48 L-Cysteine + O-succinyl-L-homoserine → Hydrogen Ion + L-Cystathionine + Succinic acid LEFT_TO_RIGHT 4.4.1.8 false 4.4.1.8 L-Cystathionine → 2-aminoprop-2-enoate + Homocysteine + Hydrogen Ion LEFT_TO_RIGHT HMDB0000742 HMDB L-Aspartate-semialdehyde C4H7NO3 L-Aspartate-semialdehyde 117.042595 C3H7NO2S L-Cysteine 121.01975 25243997 PubChem-compound 388372 ChemSpider SMILES CN1C(CNC2=CC=C(C=C2)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC([O-])=O)C([O-])=O)C([O-])=O)C([O-])=O)CNC2=C1C(=O)NC(N)=N2 C00097 KEGG Compound Bifunctional aspartokinase/homoserine dehydrogenase 1 757 ChemSpider P13009 UniProt Bifunctional aspartokinase/homoserine dehydrogenase 2 L-ASPARTATE-SEMIALDEHYDE BioCyc 22833512 PubChem-compound HOMO-SER BioCyc Homocysteine CHEBI:18051 ChEBI HMDB0012290 HMDB 3-METHYLBENZYLSUCCINYL-COA BioCyc C4H9NO3 L-Homoserine 119.05824 Transport457 false L-Methionine (→), Hydrogen Ion (←) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT 1.0 C6H14NO2S S-Methylmethionine 164.07452 Cystathionine beta-lyase metC HMDB0059597 HMDB P06721 UniProt Hydrogen Ion HMDB0038670 HMDB SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase homoserine O-succinyltransferase C02291 KEGG Compound 1.0 85-61-0 CAS cystathionine-β-lyase / L-cysteine desulfhydrase bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon Q47690 UniProt Uncharacterized protein YbjE Homoserine O- succinyltransferase Cystathionine gamma-synthase Cystathionine beta-lyase metC Protein malY 5- methyltetrahydropteroyltriglutamate- -homocysteine methyltransferase Bifunctional aspartokinase/homoserine dehydrogenase 2 Bifunctional aspartokinase/homoserine dehydrogenase 1 Methionine synthase Homocysteine S- methyltransferase L-Methionine L-Methionine H + H + L-Homoserine Succinyl-CoA CoA O-succinyl-L- homoserine L-Cysteine Succinic acid H + L-Cystathionine H + Homocysteine 2-aminoprop- 2-enoate N5-methyl-- tetrahydropteroyl tri-L-glutamate L-Methionine Tetrahydropteroyltri- L-glutamate L-Aspartate- semialdehyde H + NADPH NADP N5-methyl-- tetrahydropteroyl tri-L-glutamate Tetrahydropteroyltri- L-glutamate L-Methionine S- Methylmethionine L-Methionine H + Lysine Biosynthesis Methionine synthase
454-29-5 CAS 17215925 ChemSpider 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 439161 PubChem-compound SMILES N[C@@H](CS)C(O)=O Methionine synthase CYS BioCyc Cystathionine gamma-synthase C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 Succinic acid C05330 KEGG Compound SMILES N[C@@H](CCO)C(O)=O CHEBI:58207 ChEBI Methionine Biosynthesis CHEBI:58020 ChEBI 1.0 HMDB0000099 HMDB Homoserine O-succinyltransferase SMILES C[S+](C)CCC(N)C(O)=O C00441 KEGG Compound CHEBI:17230 ChEBI 6137 PubChem-compound Homocysteine S-methyltransferase 6816 PubChem-compound 2.0 49791978 PubChem-compound SMILES NC(=C)C([O-])=O 53-59-8 CAS SMILES N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O CHEBI:15380 ChEBI SMILES [H][C@@](CCC([O-])=N[C@@]([H])(CCC([O-])=N[C@@]([H])(CCC([O-])=O)C(O)=O)C(O)=O)(NC(=O)C1=CC=C(NC[C@@]2([H])CNC3=C(N2C)C([O-])=NC(=N)N3)C=C1)C(O)=O L-Methionine C25H40N7O19P3S Succinyl-CoA 867.1312 1038 PubChem-compound CHEBI:17561 ChEBI SMILES CSCC[C@H](N)C(O)=O CHEBI:16474 ChEBI P00935 UniProt GO:0005829 GENE ONTOLOGY 1.0 C04144 KEGG Compound L-CYSTATHIONINE BioCyc P23256 UniProt 1.0 1.0 2.1.1.10 false 2.1.1.10 Homocysteine + S-Methylmethionine ↔ Hydrogen Ion + 2 L-Methionine REVERSIBLE Bifunctional aspartokinase/homoserine dehydrogenase 2 Bifunctional aspartokinase/homoserine dehydrogenase 1 2.7.2.4 false 2.7.2.4 Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP LEFT_TO_RIGHT 1.0 NADPH 5862 PubChem-compound 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS NADP 13065-25-3 CAS P25665 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:58140 ChEBI C21H29N7O17P3 NADP 744.08325 SMP0000794 SMPDB SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 SubPathwayInteraction1649 SubPathway1649Reaction SubPathwayReaction P07623 UniProt NADPH BioCyc Hydrogen Ion C8H13NO6 O-succinyl-L-homoserine 219.07428 C3H4NO2 2-aminoprop-2-enoate 86.02475 672-15-1 CAS Cytosol 2.0 C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 SUC BioCyc ReactionCatalysis2853 ACTIVATION HMDB0000574 HMDB HMDB0001423 HMDB ReactionCatalysis2855 ACTIVATION ReactionCatalysis2854 ACTIVATION HMDB0000696 HMDB ReactionCatalysis2857 ACTIVATION ReactionCatalysis2856 ACTIVATION ReactionCatalysis2859 ACTIVATION HMDB0000217 HMDB ReactionCatalysis2858 ACTIVATION 1.0 PW000771 PathWhiz Cystathionine gamma-synthase C00006 KEGG Compound P00561 UniProt CHEBI:18009 ChEBI Hydrogen Ion 16722112 PubChem-compound P00562 UniProt C29H37N9O12 Tetrahydropteroyltri-L-glutamate 703.25616 C00005 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB 445 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 53-57-6 CAS CHEBI:15741 ChEBI 1.0 Homocysteine S-methyltransferase CHEBI:17482 ChEBI 1.0 C00010 KEGG Compound Tetrahydropteroyltri-L-glutamate 1.0 1110 PubChem-compound 1.0 NAD(P) BioCyc GO:0005620 GENE ONTOLOGY SMILES NC(CCS)C(O)=O C4H6O4 Succinic acid 118.02661 562 TAXONOMY 12126 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider TransportCatalysis392 ACTIVATION 458 PubChem-compound CPD-1302 BioCyc CHEBI:16160 ChEBI C00263 KEGG Compound MET BioCyc N5-methyl--tetrahydropteroyl tri-L-glutamate 2.0 5653 ChemSpider 56-88-2 CAS 1.0 L-Cystathionine 1.0 SMILES N[C@@H](CC=O)C(O)=O C7H14N2O4S L-Cystathionine 222.06743 1.0 ReactionCatalysis2884 ACTIVATION S-Methylmethionine C5H11NO2S L-Methionine 149.05106 1.0 52-90-4 CAS L-Homoserine CHEBI:1146900 ChEBI HMDB0000254 HMDB SMILES OC(=O)CCC(O)=O Protein malY Lysine Biosynthesis SubPathway CHEBI:15699 ChEBI HMDB0012249 HMDB CO-A BioCyc C00042 KEGG Compound 5675 ChemSpider Uncharacterized protein YbjE 1078 ChemSpider L-Cysteine 1.0 Coenzyme A 1.0 604-98-8 CAS C21H36N7O16P3S Coenzyme A 767.11523 2.0 SMILES N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O 4.0 aspartate kinase / homoserine dehydrogenase 6557 ChemSpider Cystathionine beta-lyase metC Escherichia coli 12647 PubChem-compound 17625690 ChemSpider 2.3.1.46 false 2.3.1.46 L-Homoserine + Succinyl-CoA → Coenzyme A + O-succinyl-L-homoserine LEFT_TO_RIGHT 63-68-3 CAS 5907 ChemSpider SMP0000834 SMPDB CHEBI:16643 ChEBI 1.0 N5-methyl--tetrahydropteroyl tri-L-glutamate Methionine synthase 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase O-succinyl-L-homoserine 2-aminoprop-2-enoate L-Methionine HMDB0000719 HMDB 1.0 C00073 KEGG Compound 4.0 1.0 388392 ChemSpider CHEBI:17420 ChEBI L-Methionine Homoserine O-succinyltransferase 439235 PubChem-compound C00080 KEGG Compound 110-15-6 CAS Periplasmic Space 4.0 15106-57-7 CAS Uncharacterized protein YbjE PW000814 PathWhiz HMDB0001022 HMDB C4H9NO2S Homocysteine 135.0354 ReactionCatalysis5840 ACTIVATION CHEBI:15378 ChEBI SMILES [H+] Succinyl-CoA Protein malY 5886 PubChem-compound HOMO-CYS BioCyc 2.1.1.13 false 2.1.1.13 Homocysteine + N5-methyl--tetrahydropteroyl tri-L-glutamate → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT C00091 KEGG Compound 2.1.1.13 false 2.1.1.13 N5-methyl--tetrahydropteroyl tri-L-glutamate + Homocysteine → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT P75826 UniProt 2.5.1.48 false 2.5.1.48 L-Cysteine + O-succinyl-L-homoserine → Hydrogen Ion + L-Cystathionine + Succinic acid LEFT_TO_RIGHT 4.4.1.8 false 4.4.1.8 L-Cystathionine → 2-aminoprop-2-enoate + Homocysteine + Hydrogen Ion LEFT_TO_RIGHT HMDB0000742 HMDB L-Aspartate-semialdehyde C4H7NO3 L-Aspartate-semialdehyde 117.042595 C3H7NO2S L-Cysteine 121.01975 25243997 PubChem-compound 388372 ChemSpider SMILES CN1C(CNC2=CC=C(C=C2)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC([O-])=O)C([O-])=O)C([O-])=O)C([O-])=O)CNC2=C1C(=O)NC(N)=N2 C00097 KEGG Compound Bifunctional aspartokinase/homoserine dehydrogenase 1 757 ChemSpider P13009 UniProt Bifunctional aspartokinase/homoserine dehydrogenase 2 L-ASPARTATE-SEMIALDEHYDE BioCyc 22833512 PubChem-compound HOMO-SER BioCyc Homocysteine CHEBI:18051 ChEBI HMDB0012290 HMDB 3-METHYLBENZYLSUCCINYL-COA BioCyc C4H9NO3 L-Homoserine 119.05824 Transport457 false L-Methionine (→), Hydrogen Ion (←) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT 1.0 C6H14NO2S S-Methylmethionine 164.07452 Cystathionine beta-lyase metC HMDB0059597 HMDB P06721 UniProt Hydrogen Ion HMDB0038670 HMDB SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase homoserine O-succinyltransferase C02291 KEGG Compound 1.0 85-61-0 CAS cystathionine-β-lyase / L-cysteine desulfhydrase bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon Q47690 UniProt ybjE metA metB metC malY metE metL thrA metH mmuM L-Methionine L-Methionine Hydrogen Ion Hydrogen Ion L-Homoserine Succinyl-CoA Coenzyme A O-succinyl-L- homoserine L-Cysteine Succinic acid Hydrogen Ion L-Cystathionine Hydrogen Ion Homocysteine 2-aminoprop- 2-enoate N5-methyl-- tetrahydropteroyl tri-L-glutamate L-Methionine Tetrahydropteroyltri- L-glutamate L-Aspartate- semialdehyde Hydrogen Ion NADPH NADP N5-methyl-- tetrahydropteroyl tri-L-glutamate Tetrahydropteroyltri- L-glutamate L-Methionine S- Methylmethionine L-Methionine Hydrogen Ion Lysine Biosynthesis metH