SMP0125782
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Aromatase Deficiency
Homo sapiens
Matched Description: Aromatase deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of … converts androgens to estrogens which is vital for bone growth and regulation of blood sugar levels … . Symptoms of decrease in estrogen and increase androgens such as testosterone can cause impaired female … sexual development, unusual bone growth, insulin resistance, and a variety of other symptoms. It … presents with virilization of pregnant mothers during the antenatal period, and virilization of female
Matched Protein Synonyms: 20 alpha-hydroxysteroid dehydrogenase … 20-alpha-HSD
Matched Compound Synonyms: 17-oh progesterone … (3beta)-3,17-dihydroxypregn-5-en-20-one … 5-pregnen-3beta,17alpha-diol-20-one … (3b)-3,17-dihydroxypregn-5-en-20-one … (3β)-3,17-dihydroxypregn-5-en-20-one
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SMP0063887
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Phosphatidylcholine Biosynthesis PC(20:1(11Z)/20:1(13Z))
Arabidopsis thaliana
Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. The … . Instead, they are indicated with a dark green colour and appear to be free floating in the cytosol … ethanolamine by phospholipase D. The two methylated intermediates N-methylethanolamine phosphate and N
Matched Compounds: PS(20:1(11Z)/20:1(13Z)) … PE(20:1(11Z)/20:1(13Z)) … PE-NMe(20:1(11Z)/20:1(13Z)) … PE-NMe2(20:1(11Z)/20:1(13Z)) … PC(20:1(11Z)/20:1(13Z))
Matched Compound Synonyms: Ps(20:1n9/20:1n7) … Ps(20:1w9/20:1w7) … Pser(20:1(11z)/20:1(13z)) … Pser(20:1/20:1) … Pser(20:1n9/20:1n7)
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SMP0063474
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Tropane, Piperidine, and Pyridine Alkaloid Biosynthesis
Arabidopsis thaliana
Matched Description: Tropane, piperidine, and pyridine alkaloids are alkaloid compounds found in some plants containing … , piperidine and pyridine alkaloid biosynthesis pathway consists of several separate reactions that are known … . L-phenylalanine, which may be sourced from the phenylalanine, tyrosine, and tryptophan … produce phenylpyruvate (aka. 2-oxo-3-phenylpropanoic acid) and L-glutamic acid. This reaction may be … oxygen and hydrogen to produce hydrogen peroxide, ammonia, and either 1-methylpyrrolinium or 5
Matched Compounds: 2-Oxo-3-phenylpropanoic acid (Mixture oxo and keto)
Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … [oh(oh)] … Ammonia (conc 20% or greater) … Ammonia (conc 20% or greater) … [oh(oh)]
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SMP0000370
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Tyrosinemia Type 3 (TYRO3)
Homo sapiens
Matched Description: causes tyrosine and phenylalanine to accumulate in the blood resulting in increased excretion of … tyrosine in the urine. Tyrosinemia type 3 symptoms include: seizures, mental retardation and intermittent ataxia (occasional loss of balance and coordination).
Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]
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SMP0121218
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Phenylalanine Metabolism
Danio rerio
Matched Description: of the compound. In this case, the side chain is a benzyl group, and as this is inert and hydrophobic … , leading the amino acid itself to be neutral and non-polar. Phenylalanine is also an essential … amino acid in zebrafish, meaning that they can not be synthesized de novo by the organism, and instead … phenylalanine biosynthesis, and can be converted by phenylalanine hydroxylase to L-tyrosine. L … -tyrosine can then be used in tyrosine metabolism. L-phenylalanine can also be converted to and from
Matched Compound Synonyms: Ammonia (conc 20% or greater) … [oh(oh)] … 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)]
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SMP0002359
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The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
Homo sapiens
Matched Description: producing mutIDH1 and mutIDH2 in the cytosolic and mitochondrial isoforms of isocitrate … histone lysine demethylases (KDMs) and the ten-eleven translocation (TET) family of 5 … -methylcytosine (5mC) hydroxylases. This results in modulations of HIF-mediated hypoxia responses and alterations … -hydroxyglutarate is a competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies.
Matched Protein Synonyms: F-box and leucine-rich repeat protein 11
Matched Compound Synonyms: [co2(oh)](-) … Ammonia (conc 20% or greater)
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SMP0086727
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Cardiolipin Biosynthesis CL(20:4(8Z,11Z,14Z,17Z)/20:4(8Z,11Z,14Z,17Z)/20:5(5Z,8Z,11Z,14Z,17Z)/20:5(5Z,8Z,11Z,14Z,17Z))
Caenorhabditis elegans
Matched Description: about 20% of the total lipid composition. It is essential for the optimal function of numerous … synthesizes phosphatidylglycerophosphate (PGP). Sixth, phosphatidylglycerophosphatase and protein
Matched Compounds: LPA(20:4(8Z,11Z,14Z,17Z)/0:0) … PA(20:4(8Z,11Z,14Z,17Z)/20:4(8Z,11Z,14Z,17Z)) … CDP-DG(20:4(8Z,11Z,14Z,17Z)/20:4(8Z,11Z,14Z,17Z)) … PGP(20:4(8Z,11Z,14Z,17Z)/20:4(8Z,11Z,14Z,17Z)) … PG(20:4(8Z,11Z,14Z,17Z)/20:4(8Z,11Z,14Z,17Z))
Matched Compound Synonyms: Coa(20:4(8z,11z,14z,17z)) … Lysophosphatidic acid(20:4(8z,11z,14z,17z)) … Lysophosphatidic acid(20:4n3/0:0) … Lysophosphatidic acid(20:4w3/0:0) … Lysophosphatidic acid(20:4n3)
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SMP0086708
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Cardiolipin Biosynthesis CL(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/20:4(8Z,11Z,14Z,17Z)/20:4(8Z,11Z,14Z,17Z))
Caenorhabditis elegans
Matched Description: about 20% of the total lipid composition. It is essential for the optimal function of numerous … synthesizes phosphatidylglycerophosphate (PGP). Sixth, phosphatidylglycerophosphatase and protein
Matched Compounds: LPA(20:3(8Z,11Z,14Z)/0:0) … PA(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) … CDP-DG(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) … PGP(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) … PG(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))
Matched Compound Synonyms: Coa(20:3(8z,11z,14z)) … Lpa(20:3) … Lpa(20:3(8z,11z,14z)) … Lpa(20:3n6/0:0) … Lpa(20:3w6/0:0)
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SMP0086703
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Cardiolipin Biosynthesis CL(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)/20:4(8Z,11Z,14Z,17Z)/20:5(5Z,8Z,11Z,14Z,17Z))
Caenorhabditis elegans
Matched Description: about 20% of the total lipid composition. It is essential for the optimal function of numerous … synthesizes phosphatidylglycerophosphate (PGP). Sixth, phosphatidylglycerophosphatase and protein
Matched Compounds: LPA(20:3(8Z,11Z,14Z)/0:0) … PA(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) … CDP-DG(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) … PGP(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) … PG(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z))
Matched Compound Synonyms: Coa(20:3(8z,11z,14z)) … Lpa(20:3) … Lpa(20:3(8z,11z,14z)) … Lpa(20:3n6/0:0) … Lpa(20:3w6/0:0)
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SMP0086696
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Cardiolipin Biosynthesis CL(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))
Caenorhabditis elegans
Matched Description: about 20% of the total lipid composition. It is essential for the optimal function of numerous … synthesizes phosphatidylglycerophosphate (PGP). Sixth, phosphatidylglycerophosphatase and protein
Matched Compounds: LPA(20:3(8Z,11Z,14Z)/0:0) … PA(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) … CDP-DG(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) … PGP(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) … PG(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z))
Matched Compound Synonyms: Coa(20:3(8z,11z,14z)) … Lpa(20:3) … Lpa(20:3(8z,11z,14z)) … Lpa(20:3n6/0:0) … Lpa(20:3w6/0:0)
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