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Matched Description: ) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin inhibits DNA … gyrase (topoisomerase II) and topoisomerase IV. These proteins prevent supercoiling in bacterial … DNA. The inhibition of DNA gyrase (topoisomerase II) and topoisomerase IV causes supercoiling of the bacterial DNA. This prevents DNA replication.

Matched Description: the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory … process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria … constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax those … muscles. Allergies causes blood vessel dilation which causes swelling (edema) and fluid leakage … . Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and

Matched Description: pneumonia. It acts by binding to the 30S ribosomal subunit blocking protein synthesis and disrupting … bacterial function leading to cell death. Omadacycline should be taken on an empty stomach and … multivalent ions and antacids should be avoided whilst taking omadacycline.

Matched Description: two separate osmosensors, SLN1 and SHO1. Sln1 is activated in low osmolarity, thus repressing Ssk1 by … phosphorylating it. Ssk1 is in charge of activating Ssk2/22 which in turn activates Pbs2 and in … , which in turn activates Pbs2 and activates Hog1. Ptp2 and Ptp3 negatively regulates Hog1.

Matched Description: Moricizine is an antiarrhythmic used to treat arrhythmias (irregular heartbeats) and to maintain … slowed atrioventricular nodal and His-Purkinje conduction, which decreases excitability conduction … velocity, and automaticity. It decreases the maximum rate of phase 0 depolarization, but it does not … diastolic potential. It minimally effects sinus cycle length and sinus node recovery time.

Matched Description: by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic … improving orthostatic blood pressure and alleviating associated symptoms of lightheadedness, dizziness … , blurred vision, and syncope through the induction of tachycardia (increased heart rate) and … begins. The alpha and beta/gamma subunits of the G protein separate and GDP is replaced with GTP on the … then activates protein kinase A (PKA) which in turn phosphorylates targets and inhibits MLCK through

Matched Description: Ephedrine is an alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia … , allergic conditions, bronchial asthma, and nasal congestion. It is administered as an intravenous … injection, and can be found under the brand names Akovaz, Bronkaid, Corphedra, Emerphed, Primatene … , and Rezipres. Ephedrine increases blood pressure by stimulating heart rate and cardiac output and … -adrenergic receptors in the lungs. Ephedrine is a direct and indirect sympathomimetic amine. As a direct

Matched Description: Asenapine is a serotonin, dopamine, noradrenaline, and histamine antagonist in which asenapine … antipsychotic multireceptor neuroleptic drug which shows strong 5HT2A (serotonin) and D2 (dopamine) receptor … antagonism, which has been shown to enhance dopamine (DA) and acetylcholine (Ach) efflux in rat … brains. Asenapine may improve cognitive function and negative symptoms in patients with schizophrenia.

Matched Description: Remifentanil is a pharmacologically-active, synthetic, small molecule derived from fentanyl and … receptors which are inhibitory G-coupled protein receptors and lead to the inhibition of adenylate … cyclase and decrease in cAMP production. Analgesia, anesthesia, and respiratory depression are a

Matched Description: as Retavase that is used in emergencies such as myocardial infarction, ischemic stroke and … pulmonary emboli. Reteplase is administered intravenously and travels through the bloodstream and acts on … goes to act on the fibrin matrix and degrades it into its products eliminating the blood clot.