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Matched Description: acetyltransferase resulting in the release of a coenzyme A and an acetyl phosphate. The latter compound in … turn reacts with ADP through an acetate kinase resulting in the release of an ATP and an acetate … . The acetate reacts with ATP and coenzyme A through an acetyl-CoA synthase resulting in the release of … a diphosphate, an AMP and an acetyl-CoA. Acetyl-CoA can be biosynthesized by acetoacetate reacting … with an acetyl-CoA through an acetoacetyl-CoA transferase resulting in the release of an acetate and

Matched Description: acetyltransferase resulting in the release of a coenzyme A and an acetyl phosphate. The latter compound in … turn reacts with ADP through an acetate kinase resulting in the release of an ATP and an acetate … . The acetate reacts with ATP and coenzyme A through an acetyl-CoA synthase resulting in the release of … a diphosphate, an AMP and an acetyl-CoA. Acetyl-CoA can be biosynthesized by acetoacetate reacting … with an acetyl-CoA through an acetoacetyl-CoA transferase resulting in the release of an acetate and

Matched Description: hydrogen ion and a deoxycytidine deaminase resulting in the release of an ammonium and a deoxyuridine … and a dUMP. Deoxyuridine can also react with a phosphate through a uracil phosphorylase resulting in … the release of a uracil and a deoxy-alpha-D-ribose 1-phosphate. This compound in turn reacts with a … thymine through a thymidine phosphorylase resulting in the release of a phosphate and a thymidine … . Thymidine in turn reacts with an ATP through a thymidine kinase resulting in a release of an ADP, a hydrogen ion and a dTMP

Matched Description: Tyrosine Hydroxylase (TH) Deficiency is a rare inborn error of metabolism (IEM) and autosomal … production of catecholamines such as dopamine, norepinephrine and epinephrine are all essential for normal … nervous system function. Dopamine transmits signals to help the brain control physical movement and … emotional behavior. Norepinephrine and epinephrine are involved in the autonomic nervous system … body produces less dopamine, norepinephrine and epinephrine. Symptoms of the disorder include

Matched Description: norepinephrine and serotonin reuptake in the brain. It does so by competing for the same binding site as … norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with … concentrations of both norepinephrine and serotonin in their respective synapses and reverses the state of … norepinephrine and serotonin have also been shown to have long-term neuromodulatory effects. Binding of these … enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF). BDNF

Matched Description: growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors … (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase … effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then … phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization … , therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are

Matched Description: growth and cytoskeletal reorganization. Rac1 activity is regulated by guanine nucleotide exchange factors … (GEFs). GEFs cause the release of GDP, allowing GDP to bind and Rac1 to become activated. GTPase … effectors to cytoskeleton reorganization. PAK1 phosphorylates and activates LIM kinase. LIM kinase then … phosphorylates cofilin, inactivating it leading to reduced actin filament severing and depolymerization … , therby increasing polymerized actin. Rac1 stimulates lamellipodia and filopodia formation which are

Matched Description: Atactica Polyneurtiformis; Hereditary Motor and Sensory Neuropathy IV; HSMN4; Adult Refsum Disease I … chromosome 10 (adult Refsum disease I), and by mutation of the PEX7 gene. A defect in phytanoyl-CoA … due to the inability for phytanic acid to undergo alpha and beta oxidation. Symptoms include anosmia … , ataxia, nystagmus, neurological deterioration and peripheral neuropathy. Adult Refsum disease is … distinctly different from Infantile Refsum disease both genetically and phenotypically. Infantile

Matched Description: Alfentanil is used to induce and maintain anesthesia, as well as an analgesic. Alfentanil is a … short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic … effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery … , for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill … , N-phenylpropionamide and AMX (Ci.I yellow pigment) and excreted in urine via the kidneys. Only 1.0% of the dose is excreted as unchanged drug.

Matched Description: Cocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic … proceedures or during surgery in or through the nasal cavity. It comes in drugs called Goprelto and … from depolarizing and triggering an action potential. The different types of sensory neurons it … inhibits are mechanoreceptors(pressure, vibrations, and texture), thermoreceptors (temperature), and … nociceptors (pain). The prevention of depolarization and action potential in these neurons causes an anesthetic effect in the nasal cavity.