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Matched Description: is administered orally and is metabolized by carboylesterase1 into its active metabolite (ACT-333679 … ). The metabolite has a high selectivity for prostacyclin receptor that activates it and subsequent … G coupled protein, Gs, that increases cAMP levels. Increased cAMP levels leads to inhibited platelet aggregation and activation.

Matched Description: , allowing more solute and water reabsorption. Diphenoxylate binds to opioid receptors, mainly the mu … are coupled to Gi and Go proteins. The Gi cascade results in an inhibition of adenylate cyclase … , which reduces cytosolic cAMP. Protein kinase A is activated by cAMP to open Ca2+ channels and allow Ca2 … + influx into the cytosol. A reduction in cAMP reduces the activity of protein kinase A and thus … reduces the cytosolic Ca2+. The Go signaling cascade results in activation of K+ channels and inhibition

Matched Description: and salt retention associated with congestive heart failure. In the distal convoluted tubule (DCT … ), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. In … the interstitium-blood area and K+ into the epithelial cell; the Na+/Ca2+ exchanger, which pumps Na … + into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports … epithelial cell, and a Na+/Cl- cotransporter which transports Na+ and Cl- into the epithelial cell

Matched Description: Fosamprenavir is an antiretroviral agent and prodrug of amprenavir used for the treatment and … protease. The HIV virus binds and penetrates host cell. Viral RNA is transcribed into viral DNA via … reverse transcriptase. Viral DNA enters the host nucleus and is integrated into the host DNA via … capsid and matrix protein to form the outer protein shell, and Pol encodes for the reverse … transcriptase and integrase protein to synthesize and incorporate its genome into host cells. HIV-1 protease

Matched Description: receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus … binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The … virion and translated at the rough endoplasmic reticulum into a single Genome polyprotein. The … genome polyprotein is cleaved by host and viral proteases into 10 viral proteins. The nucleocapsid … protein core and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the

Matched Description: hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In … bronchial and vascular smooth muscle, penbutolol can compete with epinephrine for beta-2 adrenergic … , which in turn activates PKA production, which then activates SRC and nitric oxide synthase, its … inhibition causes the inhibition of cAMP, PKA, SRC and nitric oxide synthase signaling. Following this … , the inhibition of SRC in essence causes the activation of Caspase 3 and Caspase 9. This Caspase

Matched Description: bacterial ribosome, by doing so the tRNA cannot bind to the site and thus no more amino acids cannot be … added to the peptide chain. Ultimately leading to protein synthesis and halting growth and

Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … vessels, and in smooth muscles of lungs and intestines to relax those muscles. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and

Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … vessels, and in smooth muscles of lungs and intestines to relax those muscles. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in

Matched Description: at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … vessels, and in smooth muscles of lungs and intestines to relax those muscles. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and