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Matched Description: Epoxysqualene biosynthesis is a pathway that begins in the chloroplast and finishes on the … dimethylallyl diphosphate from isopentenyl diphosphate. This enzyme requires FAD, NAD(P)H, and a … diphosphate then must be transported out of the chloroplast and into the cytosol via a predicted

Matched Description: encoding a reductase enzyme, and from there a chain reaction of effects lead to the observed … breakdown of many several amino acids, such as phenylalanine, is reduced and as a result their levels … deficiency include: dysphagia, global development delay, microcephaly, and intellectual disability (among

Matched Description: inborn error of metabolism (IEM) and autosomal recessive disorder caused by either a homozygous or … generalized amino aciduria and marked galactosuria. Treatment usually includes galactose restricted … with galactokinase deficiency and classic galactosemia, patients with galactose epimerase deficiency

Matched Description: , and to stop the spread of cancer cells in the human body. Specifically cancers of the rectum and of … single-strand breaks in DNA during replication. These single-strands are reversible. SN-38 and

Matched Description: other antiretroviral agents. Dolutegravir inhibits HIV integrase by binding to the active site and … step is essential in the HIV replication cycle and results in the inhibition of viral activity … . This prevents viral replication and further progression of the virus.

Matched Description: : dihydroergocornine, dihydroergocristine, and dihydroergocryptine. All these components are produced by the … fungus Claviceps purpurea and are all derivatives of the tetracyclic compound 6-methylergonovine … partial agonism/antagonism of adrenergic, dopaminergic and serotonergic receptors. The pharmacological

Matched Description: targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced … by the body, but also many medications like beta blockers, beta-2 (β2) agonists and alpha-2 (α2 … ) agonists, which are used to treat high blood pressure and asthma, for example. The α2, on the other … heterotrimeric G protein, composed of three subunits: a Gα protein such as Giα, and a complex of two … tightly linked proteins called Gβ and Gγ in a Gβγ complex. When not stimulated by a receptor, Gα is

Matched Description: encoding a reductase enzyme, and from there a chain reaction of effects lead to the observed … breakdown of many several amino acids, such as phenylalanine, is reduced and as a result their levels … include: dysphagia, global development delay, microcephaly, and intellectual disability (among

Matched Description: Lennox-Gastaut Syndrome (LGS). Rufinamide is a triazole derivative and an anticonvulsant medication to … effects on the voltage-dependence of gating and the time course of inactivation in some sodium channel … vomiting, headache, fatigue, and dizziness. Rufinamide is administered as an oral tablet or suspension.

Matched Description: Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't … activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the … in the cytosol, and it, therefore, cannot bind to calmodulin.Calcium bound calmodulin is required for