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Matched Description: . bipolar depression) in adults, as monotherapy and/or adjunctive therapy with lithium or valproate … ) receptors, resulting in reduced presynaptic release of dopamine, and antagonistic activity at … characteristic in antipsychotics. Both reduced receptor occupancy and its dual action at D2 receptors are … tardive dyskinesia and parkinsonian-like effects. These characteristics allow lumateperone to efficiently … reduce dopamine signaling. Lumateperone also targets dopamine (D1) receptors, and a useful secondary

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: . Hypertension is a very common condition in North America, and can be managed with medication, diet … and a healthy lifestyle. This pathway depicts the pharmacological action of felodipine on … arterial smooth muscle cells. Felodipine decreases arterial smooth muscle contractility and subsequent … binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation … arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of felodipine result

Matched Description: release of a phosphate and Serine which can then be used to synthesize glycine through a serine … hydroxymethyltransferase. Serine can also be incorporated into the mitochondrion and then serine can then … transformed into a 5,10 methenyltetrahydrofolate , followed by an N10 formyl tetrahydrofolate and lastly … synthesized from threonine through a threonine aldolase resulting in the release of acetaldehyde and glycine … aminotransferase resulting in the release of glycine and pyruvic acid.

Matched Description: DOPA-Responsive Dystonia is a condition in which the muscles contract, experience tremors and … of this condition are dystonia in the legs, and clubfeet. The cause of this condition is usually a … and serotonin, and the processing of quite a few amino acids, The mutation on GCH1 causes GTP … why patients with DOPA-responive dystonia experience tremors and movement problems.

Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and

Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and

Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and

Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and

Matched Description: and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylcholine … biosynthesis pathways: the Kennedy pathway and the methylation pathway. The Kennedy pathway begins … -choline and subsequently phosphatidylcholine. It is the major synthesis route in animals. In the … diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and