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Matched Description: ventricular dysrhythmias, tachycardia and atrial fibrillation. Procainamide mainly inhibits sodium channels … slows the rate of rise in the pacemaker potential and shortens the plateau phase of atrial and … channel and block it. Procainamide can be administered through either oral or intravenous routes with both … may include cardiac toxicity, bradycardia, hypotension, drug-induced lupus erythematosus-like syndrome, and blood dyscrasias.

Matched Description: found under the brand names Aptiom and Zebinix. Eslicarbazepine acetate (ESL) is an anticonvulsant … medication approved for use in Europe, the United States and Canada as an adjunctive therapy for … exert anticonvulsant activity by inhibiting repeated neuronal firing and stabilizing the inactivated … inactivated state of voltage-gated sodium channels and preventing their return to the activated state … has a role in anticonvulsant activity. Some side effects of using eslicarbazepine acetate may include dizziness, nausea, headache, and aphasia.

Matched Description: doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood … GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the … close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium … channels. This results in hyperpolarization and reduced neuronal excitability. Levorphanol acts at … A delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter

Matched Description: Sibutramine, commonly known as Meridia or Reductil, is a norepinephrine, serotonin and dopamine … reuptake inhibitor used for the treatment of obesity. This drug was withdrawn from US and Canadian … markets for increased risk of heart attack and stroke in patients with heart disease history … . Sibutramine stimulates the nervous system through the reuptake of norepinephrine, serotonin and dopamine … neuron is stimulated and fires. Sibutramine binds to the sodium-dependent dopamine transporter

Matched Description: cervical, lung, breast, and esophageal cancers. It is differentiated from natural alkaloids by its … p53 and cyclin-dependent kinase inhibitor p21. The latter protein works to inhibit cyclin-dependent … due to interrupted phosphorylation. The former protein, p53, acts on BAK and BAX to enact … way, p53 and p21 work alongside each other to promote apoptosis and terminate unhealthy cells

Matched Description: Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain … receptors and function as both positive and negative regulators of synaptic transmission via G … the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner … the activation of the reward pathway in the brain causing pleasure and addiction.

Matched Description: hydrolysis at neutral or slightly basic pH; allowing its administration to be oral and intravenous too … . Temozolomide is indicated in the treatment of newly diagnosed glioblastoma and refractory anaplastic … -carboxamide (MTIC), which then reacts with water to produce 5-aminoimidazole-4-carboxamide (AIC) and a highly … methyl diazonium cation formed methylates DNA at the N7 and O6 position of guanine, and the N3 position

Matched Description: contraction in the GI tract. This increased contractility promotes peristalsis and enhances gastric … emptying by propelling food and digestive contents through the GI tract. Specifically, Gs proteins … -dependent protein kinase A (PKA) and other cAMP-responsive proteins. Signaling through G protein-coupled … , growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture.

Matched Description: . There are currently no known activators and repressors of this operon. The first gene, ribF … , encodes for a bifunctional riboflavin kinase and FMN adenylyltransferase. In the cell, it is used to … convert riboflavin to FMN, and then FMN to FAD. The second gene, ileS, encodes the isoleucine tRNA … which works as an isomerase, and also posesses a chaperone activity, assisting in the folding of … diphosphate (DMAPP) and isopentenyl diphosphate (IPP) as part of the methylerythritol phosphate pathway involved in isoprenoid biosynthesis.

Matched Description: Escherichia coli can utilize D-mannose for its sole carbon and energy source. Alpha-D-mannose is … isomerase. D-fructose-6-phosphate is an intermediate of glycolysis and can enter the pathways of … phosphorylated aldohexoses (β-D-glucose-6-phosphate, D-mannose-6-phosphate) and phosphorylated ketohexoses (D … phosphomannomutase and mannose-1-phosphate guanylyltransferase. GDP-D-mannose produces GDP-L-fucose beginning … epimerase and reductase of GDP-4-dehydro-6-deoxy-D-mannose. L-fucose then enters the colanic acid building blocks biosynthesis pathway.