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Matched Description: Dexchlorpheniramine maleate is a first generation H1-antihistamine used to treat allergic and … vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax

Matched Description: -like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3, and H4 … . Histamine receptor H1 belongs to the family of G-protein-coupled receptors (GPCRs), and it is … expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous … system. It is linked to an intracellular G-protein (Gαq) that activates phospholipase C and the … release and expression of the NF-κB immune response transcription factor. H1-antihistamines inactivate

Matched Description: breast cancer. Tamoxifen itself only has weak anti-estrogen effects and must be converted into more … active metabolites to have therapeutic activity. Metabolism takes place in the liver and is carried out … primarily by cytochrome P450 enzymes. Tamoxifen is hydroxylated by CYP2D6 and demethylated by CYP3A4 … and CYP3A5, producing the active metabolites 4-hydroxytamoxifen and endoxifen. These metabolites

Matched Description: system within the immune system. This pathway begins with the activation of antibodies IgM and IgG … . Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes … to the infected area and sets the stage for the coming together of the membrane attack complex (MAC … ). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death.

Matched Description: Sulodexide mixture of glycosaminoglycans (GAGs), dermatan sulfate (DS) and fast-moving heparin. Its … conversion of prothrombin and thrombin. Doing that also inhibits the conversion of fibrinogen to fibrin … mainly metabolized by the liver. It is eliminated through renal, fecal and bile routes, and sometimes … and dizziness. Some allergic reactions can cause skin rash but these occurrences are rare.

Matched Description: tablet and as a topical ointment to treat bacterial infections. Neomycin is derived from Streptomyces … fradiae by-products. There are three components A, B, and C, component B is the most active. This … aminoglycoside is effective against gram-positive and gram-negative bacteria. It acts by binding to the … 30S ribosomal subunit disrupting protein synthesis and inhibiting further translation. Specifically … occur, although a prolonged administration can cause the risk of neurotoxicity, ototoxicity, and nephrotoxicity in humans.

Matched Description: atom from sulfur donors to nucleophilic sulfur acceptors, and it has been found in many major phyla … (prokaryotic and eukaryotic). The role of thiosulfate sulfurtransferase might be the detoxification of … cyanide in both bacteria and mammals, or it might also involve in formation of prosthetic groups in … iron-sulfur proteins. In this pathway, thiosulfate and hydrogen cyanide have been catalyzed by … thiosulfate sulfurtransferase to form thiocyanate and sulfite. Sulfite is used in later sulfur metabolism.

Matched Description: carbon and energy source. Naphthalene, a polycyclic aromatic hydrocarbon (PAH), enters bacterial cells … cleavage, hydroxylation, and oxidation, to produce metabolites such as Gentisate and Catechol, which … enter the Tyrosine metabolism and benzoate degradation pathways for energy generation and biosynthesis.

Matched Description: carbon and energy source. Naphthalene, a polycyclic aromatic hydrocarbon (PAH), enters bacterial cells … cleavage, hydroxylation, and oxidation, to produce metabolites such as Gentisate and Catechol, which … enter the Tyrosine metabolism and benzoate degradation pathways for energy generation and biosynthesis.

Matched Description: carbon and energy source. Naphthalene, a polycyclic aromatic hydrocarbon (PAH), enters bacterial cells … cleavage, hydroxylation, and oxidation, to produce metabolites such as Gentisate and Catechol, which … enter the Tyrosine metabolism and benzoate degradation pathways for energy generation and biosynthesis.