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Matched Description: proteins, defined by the alpha subunits they contain: the Gαs family, Gαi/Gαo family, Gαq family, and … is a heterotrimeric G protein, composed of three subunits: a Gα protein such as Gsα, and a complex … of two tightly linked proteins called Gβ and Gγ in a Gβγ complex. When not stimulated by a receptor … , Gα is bound to GDP and to Gβγ to form the inactive G protein trimer. When the receptor binds an … as a guanine nucleotide exchange factor to promote GDP release from and GTP binding to Gα, which

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: molecules. It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a … source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and … stream, and is transported to liver hepatocytes. Once in the liver, glucokinase can use the energy and

Matched Description: who are not of reproductive potential. By binding and inhibiting CYP51, oteseconazole is active … parapsilosis, Candida tropicalis, Candida lusitaniae and Candida dubliniensis. Unlike previous-generation … azole antifungals, oteseconazole has a high selectivity for CYP51 and little interaction with human … thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes … it to collapse and die.Because of its ability to bind and inhibit CYP51, oteseconazole is active

Matched Description: variety of skin fungal infections such as athlete's foot, jock itch, and ringworm.It is used to … treat a number of different yeasts and dermatophytes such as T. rubrum, T. mentagrophytes, T. tonsurans … , T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. It is … diffusing into the cell. Oxiconazole inhibits both lanosterol synthase and lanosterol 14-alpha … increasing fluidity and preventing growth of new cells. This causes the cell to collapse and die.

Matched Description: Bictegravir is an integrase inhibitor used to treat HIV-1 and HIV-2 infections. Bictegravir is … of three months without a history of failure in treatment and no known factors associated with the … antiviral activity against HIV-2 and various subtypes of HIV-1. It is used in combination with … tenofovir and emtricitabine. Bictegravir is transported into the infected cell then transported into the … integrated into the host DNA. This prevents viral replication and further progression of the virus. It

Matched Description: is also more likely to be used for pulmonary and extrapulmonary blastomycosis, histoplasmosis … , aspergillosis, and onychomycosis, but not much is known of the fungi species in those infections … of lanosterol with 3 oxygen and 3 NADPH to become 4,4-Dimethylcholesta-8,14,24-trienol with … byproducts of formic acid, 4 hydrogen ions, 4 water, and 3 NADP+. This reaction is the first step in the … biosynthesis of ergosterol which resides on fungi cell membranes and is integral to cell membrane

Matched Description: channels and typically used to treat ventricular arrhythmias. It is used to treat conditions including … sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. Tocainide is … ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and … man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and … anticholinergic and local anesthetic properties. Side effects of tocainide include nausea, vomiting, headaches, feeling dizzy, or feeling hot and flushed.

Matched Description: ABC or SLC transporters like ABCB1 and works by forming a complex with FKBP12 with inhibits … calcineurin with leads to reduced T cell signal transduction and IL-2 transcription. IL-2 is an important … mediator for T-cell activation, differentiation and migration which is through mTOR signalling. Lower … IL-2 production and signal transduction leads to less activated immune cells leading to a weaker … immune system. Cyclosporin A also inhibits the transcription for genes encoding IL-3,4,5, GM-SCF, and