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Matched Description: deactivation of protein kinase A (PKA) and the inhibition of various downstream signaling pathways … involved, the tissues in question, and the overall context of the signaling pathways. Different serotonin … , depending on the receptor subtype and downstream signaling pathways involved. Serotonin increases the … motility of the GI tract muscles, induces muscle constriction in the lungs and uterus, influences … , excites nociceptive pain neurons, and influences CNS neurons. Serotonin also plays a role in the symptoms

Matched Description: cycles: Reductive pentose phosphate cycle (Calvin-Benson cycle), C4-dicarboxylic acid cycle and … photosynthesis and takes place through three general steps (carbon fixation, reduction and regeneration … ). Plants which live in unfavorable conditions like hot and dry climates have adapted to fix carbon … acid cycle and the crassulacean acid metabolism (CAM) cycle are these alternative pathways. The C4 … night and stores it in an organic form. During the day, when the stomata is closed, the carbon

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: mild-to-moderate COVID-19. In December 2021 Paxlovid, a co-package of nirmatrelvir and ritonavir, was … conronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, and is a respiratory disease that is … capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS). COVID-19 can … endocytosis. Viral RNA is released from the mature SARS-CoV-2 virion and translated at the endoplasmic … Protein 1ab is regularly cleaved by SARS-CoV-2 3C-like proteinase nsp5 and Papain-like protease nsp3

Matched Description: used to remobilize animals after neuroleptanalgesia and is considered a non-selective antagonist to … etorphine and carfentanil. This molecule is an antagonist to Mu-type, Kappa-type, and Delta-type … it is very strong and a partial agonist of the opioid receptors. It is the strongest opioid … used in elephants, giraffes and many other big animals. This pathway is represented in Homo sapiens … calcium to enter the neuron and depolarize. The inhibition of mu-opioid receptors prevents

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: . bipolar depression) in adults, as monotherapy and/or adjunctive therapy with lithium or valproate … ) receptors, resulting in reduced presynaptic release of dopamine, and antagonistic activity at … characteristic in antipsychotics. Both reduced receptor occupancy and its dual action at D2 receptors are … tardive dyskinesia and parkinsonian-like effects. These characteristics allow lumateperone to efficiently … reduce dopamine signaling. Lumateperone also targets dopamine (D1) receptors, and a useful secondary

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: . Hypertension is a very common condition in North America, and can be managed with medication, diet … and a healthy lifestyle. This pathway depicts the pharmacological action of felodipine on … arterial smooth muscle cells. Felodipine decreases arterial smooth muscle contractility and subsequent … binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation … arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of felodipine result

Matched Description: release of a phosphate and Serine which can then be used to synthesize glycine through a serine … hydroxymethyltransferase. Serine can also be incorporated into the mitochondrion and then serine can then … transformed into a 5,10 methenyltetrahydrofolate , followed by an N10 formyl tetrahydrofolate and lastly … synthesized from threonine through a threonine aldolase resulting in the release of acetaldehyde and glycine … aminotransferase resulting in the release of glycine and pyruvic acid.