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Matched Description: Spironolactone is a steroidal, non specific, orally administered aldosterone antagonist used mainly … , hypertension, adrenal hyperplasia, edema, and nephrotic syndrome. It has also been shown to decrease … proteinuria. Spironolactone can be found under the brand names Aldactazide, Aldactone, and Carospir … sodium (Na+) and water (H2O) excretion and potassium (K+) retention. Once spironolactone is bound to the … MR, it blocks aldosterone from binding which inhibits aldosterone dependent sodium potassium

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone

Matched Description: The proximal convoluted tubule is part of the nephron between the Bowman's capsule and the loop of … Henle. The proximal convoluted tubule functions to reabsorb sodium, water, and other ions. Sodium … and bicarbonate (hydrogen carbonate) are transported by a co-transporter that is responsible for the … and apical membranes, respectively, to effectively regulate the pH of the filtrate. In addition … occurrence explains solute movement secondary to water flow. All the cation and anion transport

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: of the MRs such as aldosterone, cortisol, and 11-deoxycorticosterone; preventing receptor activation … in the zone glomerulosa. Aldosterone acts on receptors in collecting and distal tubules of the … nephron causing increased reabsorption of Na+ and increased secretion of K+. Aldosterone binds to … stage kidney disease, cardiovascular death, heart attack, and hospitalization for heart failure in … help in reducing inflammation, fibrosis, and improving proteinuria, along with severe congestive

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone

Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline. This … disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine … . Symptoms of the disorder include urolithiasis and mental retardation.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: enzyme results in accumulation of ammmonia and reticulocytes in blood; glutamine in plasma, carnitine … and ferritin in serum, and arginine, lysine and ornithine in urine. Symptoms include bone marrow … abnormality, growth retardation, hyperammoniemia, mental retardation, pancreatitis, and seizures.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: responsible for approximately 90% of the kidney's reabsorption of glucose, and can be found in the S1 … kidney. There are some drugs that inhibit SGLT2 and are used to decrease blood sugar in patients with type 2 diabetes mellitus.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3A … Neutral and basic amino acid transport protein rBAT

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: Ibuprofen is a very common NSAID drug used to treat pain and inflammation. This includes headaches … , muscle pain and fever. It is sold under the brand name Advil or Motrin. Ibuprofen is typically … prostaglandin G/H synthase (COX). These enzymes are available as COX1 and COX2, and are encoded by … PTGS1 (COX1) and PTGS2 (COX2). Ibuprofen may also inhibit fatty acid amide hydrolase (FAAH), which

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-leukotriene b4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-ltb4 … 20-carboxy-leukotriene b4

Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Fosinopril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: of acute myocardial infaction (AMI), hypertension and mild to mmoderate hypertension. Zafenopril … has the ability to improve endothelial function and protect against ischemia. Zofenopril is a prodrug … and this leads to an increase of blood pressure. This system starts with the renin being released from … . Angiotensin II binds to AT1 and AT2, these receptors will activate many signaling cascades that … will lead to the retaining of sodium and water in the renal tubules. At the same time, these receptors

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone