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Matched Description: purposes including retention of the folates within the cell and an increase in their binding strength … . Folate (and folate derivatives) polyglutamylation occurs in the cytosol. Tetrahydrofolate can be … -formyltetrahydrofolate synthetase) and a 5,10-methylene-tetrahydrofolate (catalyzed by serine hydroxymethyltransferase … -[gamma-Glu](n) becoming methylene-tetrahydropteroyl-[gamma-Glu](n+1), and 10-formyl-tetrahydropteroyl

Matched Description: Letermovir is an antiviral medication that treats cytomegalovirus (CMV) infections and disease in … by the FDA on November 8, 2017 and is the first of the DNA terminase complex inhibitors for CMV … of multiple subunits (pUL51, pUL56, and pUL89). Viral DNA is produced in a single repeating strand … cutting the DNA and packaging it inside the viral capsid. Thie produces immature, non-infective viruses.

Matched Description: Cocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic … proceedures or during surgery in or through the nasal cavity. It comes in drugs called Goprelto and … also inhibits dopamine, serotonin, and norepinephrine re-uptake channels. Cocaine inhibits the … vessels especially in the nose. This also causes higher heart rate and higher blood pressure, due

Matched Description: a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism … . Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 … extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection.

Matched Description: , tinnitus, nystagmus, nausea, and vomiting. Cinnarizine could be also viewed as a nootropic drug … effect of boosting brain oxygen supply. Cinnarizine is an antihistamine and a calcium channel blocker … . Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type … irritation, hypersensitivity reactions, as well as movement problems/muscle rigidity, and tremor.

Matched Description: acyl-coenzyme A synthetase ACSM2B. Coenzyme A and ATP are also involved in this first step and AMP … and pyrophosphate will be generated during the first step of metabolism. In the second step … , phenylacetyl-CoA and L-glutamine interacts with glycine N-acyltransferase to generate coenzyme A as well as

Matched Description: Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex … hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is … the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are … the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The

Matched Description: ligand CD40L, also known as CD154, CD40-CD40L interaction initializes the activation and proliferation … cell surfaces such as endothelial cells, fibroblasts, hematopoietic progenitors, platelets, and basal … -kinase, signal transducers and activators of transcription, and phosphoinositide 3-kinase pathways

Matched Description: tract infections, gonorrhea, early Lyme disease, and impetigo. Cefuroxime is a β-lactam type antibiotic … proteins are responsible for glycosyltransferase and transpeptidase reactions that lead to cross … -linking of D-alanine and D-aspartic acid in bacterial cell walls. Inhibition of this protein leads to … upregulation of autolytic enzymes and inhibition of cell wall synthesis. Since cefotaxime is bactericidal, it kills off the bacteria that it affects.

Matched Description: Oritavancin is an antibacterial agent used to treat acute bacterial skin and skin structure … adult patients with acute bacterial skin and skin structure (including subcutaneous) infection. It is … used for confirmed/suspected infections with designated and susceptible gram-positive organisms. The … cell wall is vital for the survival and replication of bacteria, making it a primary target for