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Matched Description: The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS. Peripheral receptors have … important roles in the function of many organ responses (alimentary tract, urinary bladder, heart, and … secretion, and the peristaltic reflex. Urinary bladder receptors control cholinergic/purinergic … transmission. Atrial heart receptors produce positive inotropy and tachycardia that can precipitate … , memory, mood, and respiration. The 5-HT4 receptor activates G(s) proteins which lead to the activation of

Matched Description: The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS. Peripheral receptors have … important roles in the function of many organ responses (alimentary tract, urinary bladder, heart, and … secretion, and the peristaltic reflex. Urinary bladder receptors control cholinergic/purinergic … transmission. Atrial heart receptors produce positive inotropy and tachycardia that can precipitate … , memory, mood, and respiration. The 5-HT4 receptor activates G(s) proteins which lead to the activation of

Matched Description: located in the ovary, testis, and uterus. As its name suggests, the receptor is activated by follicle … -stimulating hormone (FSH) and plays an important role in the regulation of reproduction. In the … leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. cAMP then

Matched Description: channels, cyclic nucleotide-activated nonselective cation channels, and store-operated Ca(2+) channels … +)-dependent BK(Ca) channels (slo), inwardly rectifying K(+) channels, Ca(2+)-activated Cl(-) channel and … volume-regulated anion channel (VRAC). VRAC channels can also transport organic osmolytes and amino acid.

Matched Description: The 5-HT6 receptor is primarily expressed in the brain and is involved in glutamatergic and

Matched Description: receptor located most prominently in the ovary and testis but also found in organs such as the uterus … , breasts, prostate, and seminal vesicles. As its name suggests, the receptor is activated by both … luteinizing hormone (LH) and chorionic gonadotropins (e.g. hCG) and plays an important role in the … ) leads to follicular maturation and ovulation. In the testis, LHCGR activation is essential for … testosterone production and spermatogenesis. The LHCGR receptor activates G(s) proteins which leads to the

Matched Description: Cadmium (Cd(2+)) exposure increases the risk of cancer in humans and animals. Humans may come into … contact with cadmium when smoking and ingesting contaminated food. This will increase the risk of … lung cancer and prostate cancer. In the millimolar range, cadmium will inhibit cell growth. Cadmium … induces DNA synthesis and proliferation and affects signal transduction and mobilization in … thymidine uptake and cell counts. Activating this pathway will increase the availability of the

Matched Proteins: CUB and zona pellucida-like domain-containing protein 1

Matched Description: choline rich foods such as eggs or meat enter the gut and get metabolized to trimethylamine by gut … then enters a liver hepatocyte through portal circulation and gets metabolized by FMO3 to form TMAO … high levels of it are retained in the blood and not excreted in urine. TMAO is shown to cause coronary … atherosclerosis, renal fibrosis through interaction with TGF-β1/Smad3 pathway, and increased

Matched Description: substrate, dGTP and by incorporation into viral DNA. Zidovudine triphosphate lacks the 3'-OH group which … infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid containing … its RNA and reverse transcriptase into the cytosol of the cell. The reverse transcriptase converts … transcription is transported back to the cytosol through the nuclear pore complex and translation occurs to … produce viral proteins. These viral proteins are assembled and new HIV viruses bud from the cell

Matched Description: because of the downstream production of angiotensin II and aldosterone production triggered by renin … tachycardias, and atrial fibrillation. It can be found under the brand names Viskazide and Visken. Pindolol … research into the use of pindolol found it had chronotropic effects, and so further investigation focused … decreased heart rate and blood pressure. Beta-1 receptors are G-protein-coupled receptors (specifically Gs … alpha subunit) whose action is exerted through the cyclic AMP (cAMP) and cAMP-dependent protein